Article
Biology
E. Girola, R. A. Dunlop, M. J. Noad
Summary: Animal communication systems have evolved in the presence of natural noise, and many species have a Lombard response. Human activities generate additional noise in the environment, posing further challenges for animals. This study investigated the Lombard response of humpback whales to motor vessel noise and found that they adjust their singing levels to compensate for wind noise but do not increase their levels for the additional vessel noise. Understanding the response of humpback whales to noise is crucial for developing mitigation policies for anthropogenic activities at sea.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Masaki Matsubara, Yukiko Muraki, Noriyuki Hatano, Hiroka Suzuki, Katsuhiko Muraki
Summary: The synthetic compound JT010 selectively activates human TRPA1 (hTRPA1) but has little effect on mouse TRPA1 (mTRPA1). This finding is important for understanding the function of TRPA1 and the mechanisms involved in inflammatory pain sensation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rebecca Hooper, Ella Meekins, Guillam E. McIvor, Alex Thornton
Summary: Individuals are expected to manage their social relationships to maximize fitness returns, but studies have found behaviors that do not align with traditional concepts of consolation. Experimental results show that male jackdaws do not respond to their mate's stress states with consolation, challenging previous assumptions.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Immunology
Dong Yang, Hin Chu, Gang Lu, Huiping Shuai, Yixin Wang, Yuxin Hou, Xi Zhang, Xiner Huang, Bingjie Hu, Yue Chai, Terrence Tsz-Tai Yuen, Xiaoyu Zhao, Andrew Chak-Yiu Lee, Ziwei Ye, Cun Li, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Jasper Fuk-Woo Chan
Summary: Macrophages and dendritic cells play different roles in Zika virus infection, with macrophages restricting viral replication while dendritic cells may be exploited to facilitate virus replication.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Cell Biology
Zhihui Li, Linhao Li, Scott Heyward, Shuaiqian Men, Meishu Xu, Tatsuya Sueyoshi, Hongbing Wang
Summary: The study reveals that phenobarbital significantly elevates the expression of SLC13A5 in human primary hepatocytes through the activation of PXR but not CAR.
Article
Immunology
Mickey V. Patel, Daniel C. Hopkins, Fiona D. Barr, Charles R. Wira
Summary: The study demonstrates that the effects of E-2 and P on IFN lambda 1-induced ISGs are cell-type specific, with E-2 having a suppressive effect on antiviral ISG expression in uterine epithelial cells and P potentiating the expression of certain genes. This suggests that the effects of IFN lambda 1 may vary with menstrual cycle stage and physiological status.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A. Steen
Summary: This study compared the aggregation pattern of Tau protein in mouse models of Alzheimer's Disease (AD) with that in human AD patients. The findings show that the mouse models accurately reflect early-stage Tau pathology but fail to represent late-stage changes seen in human AD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Virology
Camila Metz-Zumaran, Carmon Kee, Patricio Doldan, Cuncai Guo, Megan L. Stanifer, Steeve Boulant
Summary: This study demonstrates that both type I and III interferons can inhibit SARS-CoV-2 infection in human intestinal cells, but type III interferons exhibit stronger antiviral activity. Shorter treatment times and lower concentrations are required for type III interferons to effectively reduce virus load. Furthermore, type III interferons can significantly inhibit SARS-CoV-2 even 4 hours post-infection and induce a long-lasting antiviral effect in intestinal epithelial cells.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Quynh T. Phan, Norma Solis, Jianfeng Lin, Marc Swidergall, Shakti Singh, Hong Liu, Donald C. Sheppard, Ashraf S. Ibrahim, Aaron P. Mitchell, Scott G. Filler
Summary: The invasion of vascular endothelial cells by Candida spp. is an important step in the pathogenesis of hematogenously disseminated candidiasis. This study reveals that Candida glabrata and other Candida spp. can adhere to and invade human endothelial cells by using the serum proteins kininogen and vitronectin as bridging molecules. These serum proteins interact with the globular C1q receptor (gC1qR) and alpha v integrins on the endothelial cell surface, inducing endocytosis. This mechanism is not supported by mouse endothelial cells, but can be restored in mouse endothelial cells expressing human gC1qR or integrin alpha v. Therefore, bridging molecule-mediated endocytosis is a common mechanism by which medically important Candida spp. invade human vascular endothelial cells.
Article
Immunology
Ee Shan Pang, Ghazal Daraj, Katherine R. Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S. Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T. Kile, Kate E. Lawlor, Kristen J. Radford, Mark D. Wright, Meredith O'Keeffe
Summary: This study compared the responses of mouse and human plasmacytoid DCs and conventional DC subsets upon STING activation. It was found that both mouse and human DC subsets were activated by STING stimulation and produced Type I interferons. However, only human DCs produced large amounts of IFN-lambda 1, which is not expressed in the mouse genome. Additionally, mouse plasmacytoid DCs underwent rapid cell death upon STING activation, while human plasmacytoid DCs did not.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Yuiko Goto, Yoko Sato, Hitoshi Ikeda, Chisato Onitsuka, Hiroki Sato, Kaho Akimoto, Takaya Ebato, Hiromitsu Suganuma, Tomoko Kawahara, Hatsuko Mikuni, Yoshitaka Uchida, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara
Summary: This study found that the expression of type III interferons (IFNs) is associated with disease severity in COVID-19 patients. The low expression of IL-28A/IFN-lambda 2 may predict the severity of COVID-19 and possibly through the mechanism of delayed viral elimination.
SCIENTIFIC REPORTS
(2022)
Article
Toxicology
Christiane Wiemann, Stephanie Melching-Kollmuss, Nina Hambruch, Lucille Wiss, Franz Stauber, Lysiane Richert
Summary: The fungicide boscalid induces thyroid histopathological and hormone effects in rats by inducing liver enzymes. To evaluate the human relevance of liver enzyme induction and its effect on thyroid hormone disruption, an in vitro study was conducted on T4-glucuronidation comparing rat and human hepatocytes. The study found that boscalid induced CYP enzymes and increased T4-glucuronidation in both rat and human hepatocytes, but there were species differences in the induction pattern of UGT genes. Overall, significant increases in T4-glucuronidation were observed in rat hepatocytes but not in human hepatocytes with boscalid exposure.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Virology
Patricio Doldan, Jin Dai, Camila Metz-Zumaran, John T. Patton, Megan L. Stanifer, Steeve Boulant
Summary: Rotavirus is a common cause of gastroenteritis worldwide, especially in developing countries where it can lead to over 200,000 deaths in infants and children. Research indicates that while rotavirus can block the induction of type I interferons, it is unable to block the production of type III interferons, which play a key role in limiting rotavirus infection.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patricia G. de la Sota, Elena Lorente, Laura Notario, Carmen Mir, Oscar Zaragoza, Daniel Lopez
Summary: HRSV is a common cause of severe respiratory infections in infants and young children, as well as a serious health risk for immunocompromised individuals and the elderly. The development of antiviral treatments against HRSV is considered a global health priority. The study found that mitoxantrone inhibits HRSV replication in vitro, but not in vivo in a mice model, providing implications for preclinical studies of drug candidates.
Article
Multidisciplinary Sciences
Roobina Boghozian, Sorabh Sharma, Kamal Narayana, Manjinder Cheema, Craig E. Brown
Summary: Although microglia have the ability to migrate, only a small population of microglia show mobility under normal conditions. Following injury, the proportion of mobile microglia increases, and male microglia migrate significantly greater distances compared to their female counterparts. The signaling pathway involving interferon gamma plays a role in promoting migration in male mice, while female microglia are generally unaffected by these signals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Teresa Cesaro, Yohei Hayashi, Fabian Borghese, Didier Vertommen, Fanny Wavreil, Thomas Michiels
Summary: PKR, known for its role in viral infection response and cellular homeostasis, was found to have novel phosphorylation sites at Ser6 and Ser97 in this study. Modulating the phosphorylation status at these sites can regulate PKR activity.
SCIENTIFIC REPORTS
(2021)
Review
Virology
Belen Lizcano-Perret, Thomas Michiels
Summary: Picornaviruses disrupt host nucleocytoplasmic trafficking by targeting FG-nucleoporins in the nuclear pore complex, leading to increased viral genome translation and replication. This interference affects innate immune responses and ribosomal machinery availability, facilitating viral RNA translation.
Article
Multidisciplinary Sciences
Frederic Sorgeloos, Michael Peeters, Yohei Hayashi, Fabian Borghese, Nicolas Capelli, Melissa Drappier, Teresa Cesaro, Didier Colau, Vincent Stroobant, Didier Vertommen, Gregory de Bodt, Stephane Messe, Ignasi Forne, Felix Mueller-Planitz, Jean-Francois Collet, Thomas Michiels
Summary: Microbes have evolved to exploit cellular kinases called RSKs, which play a role in defending against pathogens. Kaposi's sarcoma-associated herpesvirus and Yersinia use a similar strategy to manipulate RSKs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Mathilde Choteau, Anais Scohy, Stephane Messe, Mathieu Luyckx, Melanie Dechamps, Virginie Montiel, Jean Cyr Yombi, Damien Gruson, Nisha Limaye, Thomas Michiels, Laure Dumoutier
Summary: More than a year into the pandemic, COVID-19 continues to be a global health emergency. The role of antibodies in viral clearance and disease severity remains controversial. Patients with severe COVID-19, including those who died, have higher levels of virus-specific antibodies, indicating that fatal infection is not associated with a deficient humoral response. Most recovered patients still have antibodies against SARS-CoV-2 more than 3 months after infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Isabelle Desombere, Freya Van Houtte, Ali Farhoudi, Lieven Verhoye, Caroline Buysschaert, Yvonne Gijbels, Sibyl Couvent, Wilfried Swinnen, Hans Van Vlierberghe, Andre Elewaut, Andrea Magri, Zania Stamataki, Philip Meuleman, Jane A. McKeating, Geert Leroux-Roels
Summary: Hepatitis C virus can be transmitted by B cells, but B cells from recently infected patients failed to transmit the virus to mice, while all serum samples were infectious. The study also observed an association between circulating antibodies and B cell transmission of HCV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Laura Collignon, Lieven Verhoye, Renate Hakze-Van der Honing, Wim H. M. Van der Poel, Philip Meuleman
Summary: The hepatitis E virus (HEV) causes 20 million infections annually worldwide, with immunocompromised individuals at risk of developing chronic infections. Human liver-chimeric mice have been instrumental in HEV research, but only two genotypes have been studied in this model. Recent studies show susceptibility of nude Balb/c mice to a HEV-4 strain.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Thomas Burkard, Nora Proske, Kathrin Resner, Laura Collignon, Leonard Knegendorf, Martina Friesland, Lieven Verhoye, Ibrahim M. Sayed, Yannick Bruggemann, Maximilian K. Nocke, Patrick Behrendt, Heiner Wedemeyer, Philip Meuleman, Daniel Todt, Eike Steinmann
Summary: This study found direct interference between HCV and HEV in human hepatocytes and humanized mice. The protease activity of HCV was found to be linked to this interference. In vivo experiments confirmed that super-infection reduced the replication of both viruses in individual mice.
Article
Microbiology
Christian Heuss, Paul Rothhaar, Rani Burm, Ji-Young Lee, Philipp Ralfs, Uta Haselmann, Luisa J. Stroh, Ombretta Colasanti, Cong Si Tran, Noemi Schafer, Paul Schnitzler, Uta Merle, Ralf Bartenschlager, Arvind H. Patel, Frederik Graw, Thomas Krey, Vibor Laketa, Philip Meuleman, Volker Lohmann
Summary: This study reports an efficient infectious cell culture model for hepatitis C virus (HCV), which can be used for studying infection mechanisms and developing vaccines. The model, generated from a consensus gt1b genome, underwent long-term passaging to adapt and produce high levels of transmissible infectivity. The study's findings are important for understanding the transmission mechanisms of HCV and for research and prevention of HCV.
Article
Gastroenterology & Hepatology
Rani Burm, Panagiota Maravelia, Gustaf Ahlen, Sandra Ciesek, Noelia Caro Perez, Anna Pasetto, Stephan Urban, Freya Van Houtte, Lieven Verhoye, Heiner Wedemeyer, Magnus Johansson, Lars Frelin, Matti Sallberg, Philip Meuleman
Summary: This study demonstrates the immunogenicity and effectiveness of preS1-HDAg immunotherapy in preventing HBV and HDV infections both in vitro and in vivo. The vaccine can complement current and future therapies for the control of chronic HBV and HDV infection.
Article
Gastroenterology & Hepatology
Nadja Meumann, Marti Cabanes-Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien-Huber, Ahmed Abdelrahman, Xuan-Khang Vu, Liang Zhang, Ann-Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez-Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwable, Leszek Lisowski, Hildegard Buning
Summary: This article reports two gene vector variants, MLIV.K and MLIV.A, which were obtained through in vivo AAV peptide display selection in mice. They showed improved hepatocyte targeting and transduction efficiency compared to AAV2 and AAV8, and have potential for liver disease treatment.
Article
Cell Biology
Mohammad Kabbani, Eleftherios Michailidis, Sandra Steensels, Clifton G. Fulmer, Joseph M. Luna, Jeremie Le Pen, Matteo Tardelli, Brandon Razooky, Inna Ricardo-Lax, Chenhui Zou, Briana Zeck, Ansgar F. Stenzel, Corrine Quirk, Lander Foquet, Alison W. Ashbrook, William M. Schneider, Serkan Belkaya, Gadi Lalazar, Yupu Liang, Meredith Pittman, Lindsey Devisscher, Hirosh Suemizu, Neil D. Theise, Luis Chiriboga, David E. Cohen, Robert Copenhaver, Markus Grompe, Philip Meuleman, Baran A. Ersoy, Charles M. Rice, Ype P. de Jong
Summary: Research shows that PNPLA3-148M variant in human hepatocytes exacerbates advanced non-alcoholic fatty liver disease (NAFLD). These models will aid in understanding the contribution of human genetic variants to advanced fatty liver diseases.
Article
Microbiology
Belen Lizcano-Perret, Cecile Lardinois, Fanny Wavreil, Philippe Hauchamps, Gaetan Herinckx, Frederic Sorgeloos, Didier Vertommen, Laurent Gatto, Thomas Michiels
Summary: It has been discovered that certain pathogen proteins can hijack cellular protein kinases to promote their own replication or evade immunity by redirecting them to specific substrates.
Article
Gastroenterology & Hepatology
Rani Burm, Freya Van Houtte, Lieven Verhoye, Ahmed Atef Mesalam, Sandra Ciesek, Philippe Roingeard, Heiner Wedemeyer, Geert Leroux-Roels, Philip Meuleman
Summary: This study evaluated a specific antibody against HBV/HDV infection and found that it could prevent infection and reduce viral loads, providing a valuable candidate for the functional cure of chronic HBV and HDV infections.
Meeting Abstract
Gastroenterology & Hepatology
Lars Frelin, Panagiota Maravelia, Rani Burm, Gustaf Ahlen, Lieven Verhoye, Freya Van Houtte, Philip Meuleman, Matti Sallberg
Meeting Abstract
Gastroenterology & Hepatology
Lars Frelin, Panagiota Maravelia, Rani Burm, Yi Ni, Gustaf Ahlen, Lieven Verhoye, Freya Van Houtte, Anna Pasetto, Stephan Urban, Philip Meuleman, Matti Saellberg
JOURNAL OF HEPATOLOGY
(2022)
