Lipid metabolism and lipid signals in aging and longevity

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UPRER promotes lipophagy independent of chaperones to extend life span

(2020) Joseph R. Daniele et al.   Science Advances

Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans

(2020) Ayse Sena Mutlu et al.   Nature Communications

Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity

(2020) Wei-Wen Chen et al.   Nature Chemical Biology

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

(2019) Alice L. Chen et al.   Nature Chemical Biology

Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity

(2019) Prasanna V. Ramachandran et al.   DEVELOPMENTAL CELL

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

The role of lipids in aging-related metabolic changes

(2019) Irene de Diego Tamayo et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Gi/o-Protein Coupled Receptors in the Aging Brain

(2019) Patrícia G. de Oliveira et al.   Frontiers in Aging Neuroscience

Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8

(2019) Matthew C. Tillman et al.   Scientific Reports

XBP-1 Remodels Lipid Metabolism to Extend Longevity

(2019) Soudabeh Imanikia et al.   Cell Reports

ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans

(2019) Nava Zaarur et al.   Molecular Metabolism

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

(2019) T. Keith Blackwell et al.   GENETICS

Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases

(2019) Maddalena Grieco et al.   Frontiers in Neuroscience

Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling

(2019) Sebastian Schmeisser et al.   Cell Reports

Exploring GPCR–Lipid Interactions by Molecular Dynamics Simulations: Excitements, Challenges, and the Way Forward

(2018) Durba Sengupta et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lithocholic Acid Improves the Survival of Drosophila Melanogaster

(2018) Stefanie Staats et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

(2018) Clea Bárcena et al.   Cell Reports

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood

(2018) Gilles Storelli et al.   DEVELOPMENTAL CELL

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

(2017) Shuo Han et al.   NATURE

Microbial metabolites regulate host lipid metabolism through NR5A–Hedgehog signalling

(2017) Chih-Chun Janet Lin et al.   NATURE CELL BIOLOGY

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites

(2017) Walter W Chen et al.   Nature Protocols

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

High-throughput screens using photo-highlighting discover BMP signaling in mitochondrial lipid oxidation

(2017) Yong Yu et al.   Nature Communications

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins

(2017) Khanichi N. Charles et al.   Cell Reports

The Brain Metabolome of Male Rats across the Lifespan

(2016) Xiaojiao Zheng et al.   Scientific Reports

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast

(2016) Witawas Handee et al.   PLoS Genetics

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants

(2016) Robert J. Shmookler Reis et al.   Aging-US

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice

(2016) Ryan S. Streeper et al.   Aging-US

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

(2016) Ivan Montoliu et al.   Aging-US

Autophagy-mediated longevity is modulated by lipoprotein biogenesis

(2015) Nicole E. Seah et al.   Autophagy

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

(2015) Kristopher Burkewitz et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

(2015) T. Keith Blackwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

(2015) Junji Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

(2015) A. Folick et al.   SCIENCE

Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine

(2015) J.-X. Cheng et al.   SCIENCE

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

Exome sequencing of three cases of familial exceptional longevity

(2014) Timothy P. Cash et al.   AGING CELL

Diacylglycerol lipaseregulates lifespan and oxidative stress response by inversely modulating TOR signaling inDrosophilaandC. elegans

(2014) Yen-Hung Lin et al.   AGING CELL

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

(2014) Céline E. Riera et al.   CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering

(2014) Lu Wei et al.   NATURE METHODS

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans

(2014) Manjunatha Thondamal et al.   Nature Communications

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

(2014) Ramesh Ratnappan et al.   PLoS Genetics

Lipidomics of familial longevity

(2013) Vanessa Gonzalez-Covarrubias et al.   AGING CELL

Glucagon-Like Peptide-1: Glucose Homeostasis and Beyond

(2013) Young Min Cho et al.   Annual Review of Physiology

A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel

(2013) Rui Xiao et al.   CELL

The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans

(2013) Daniel B. Magner et al.   Cell Metabolism

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Functional Loss of Two Ceramide Synthases Elicits Autophagy-Dependent Lifespan Extension in C. elegans

(2013) Mai-Britt Mosbech et al.   PLoS One

What are lipoproteins doing in the brain?

(2013) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans

(2013) Bree N. Heestand et al.   PLoS Genetics

The extreme longevity ofArctica islandicais associated with increased peroxidation resistance in mitochondrial membranes

(2012) Daniel Munro et al.   AGING CELL

The mystery of C. elegans aging: An emerging role for fat

(2012) Daniel Ackerman et al.   BIOESSAYS

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

The lifespan of Korean eunuchs

(2012) Kyung-Jin Min et al.   CURRENT BIOLOGY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Serum ceramides increase the risk of Alzheimer disease: The Women's Health and Aging Study II

(2012) M. M. Mielke et al.   NEUROLOGY

Lessons from C. elegans: signaling pathways for longevity

(2012) Louis R. Lapierre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor Partnerships

(2012) Pranali P. Pathare et al.   PLoS Genetics

Insulin Signaling Regulates Fatty Acid Catabolism at the Level of CoA Activation

(2012) Xiaojun Xu et al.   PLoS Genetics

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

Novel Functions of Lipid-binding Protein 5 inCaenorhabditis elegansFat Metabolism

(2011) Mo Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

(2011) Mark Lucanic et al.   NATURE

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

(2011) Jérôme Goudeau et al.   PLOS BIOLOGY

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

(2010) S. Michal Jazwinski et al.   AGING CELL

Fatty acid amide signaling molecules

(2010) Cyrine Ezzili et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity

(2010) Qiong Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

(2010) P. Chakrabarti et al.   DIABETES

mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3-L1 Adipocytes

(2010) Ghada A. Soliman et al.   LIPIDS

Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network

(2010) H Efsun Arda et al.   Molecular Systems Biology

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase in sphingolipid catabolic enzyme activity during aging

(2009) Santosh J Sacket et al.   ACTA PHARMACOLOGICA SINICA

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation

(2009) Laura Palanker et al.   Cell Metabolism

C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles

(2009) Eyleen J. O'Rourke et al.   Cell Metabolism

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

(2009) V. Menuz et al.   SCIENCE

Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz

(2009) Julie Hull-Thompson et al.   PLoS Genetics

Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress

(2008) Maria D. Ganfornina et al.   AGING CELL

A 13C Isotope Labeling Strategy Reveals the Influence of Insulin Signaling on Lipogenesis in C. elegans

(2008) Carissa L. Perez et al.   Cell Metabolism

TRPV1-null mice are protected from diet-induced obesity

(2008) Arianne L. Motter et al.   FEBS LETTERS

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila

(2008) J. Muffat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila germ-line modulation of insulin signaling and lifespan

(2008) T. Flatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE

A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival, and Adult Lifespan

(2008) Brian H. Lee et al.   PLoS Genetics