标题
Recent Advances on the Selection Methods of DNA‐Encoded Libraries
作者
关键词
-
出版物
CHEMBIOCHEM
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2021-04-23
DOI
10.1002/cbic.202100144
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries
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- Design of an Automated Reagent-Dispensing System for Reaction Screening and Validation with DNA-Tagged Substrates
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- Aptamer displacement reaction from live-cell surfaces and its applications
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- DNA-Encoded Combinatorial Library of Macrocyclic Peptoids
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- Analysis and Modelling of Large and Heterogeneous Populations of DNA Using a PCR‐Based Method
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- Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells
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- Off-DNA DNA-Encoded Library Affinity Screening
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- Exploring the Lower Limit of Individual DNA-Encoded Library Molecules in Selection
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- Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
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- Small-Molecule Positive Allosteric Modulators of theβ2-Adrenoceptor Isolated from DNA-Encoded Libraries
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- Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules
- (2018) Dmitry L. Usanov et al. Nature Chemistry
- Evolution of sequence-defined highly functionalized nucleic acid polymers
- (2018) Zhen Chen et al. Nature Chemistry
- What Do You Get from DNA-Encoded Libraries?
- (2018) Alexander L. Satz ACS Medicinal Chemistry Letters
- tagFinder: A Novel Tag Analysis Methodology That Enables Detection of Molecules from DNA-Encoded Chemical Libraries
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- Design and Development of a Technology Platform for DNA-Encoded Library Production and Affinity Selection
- (2018) Jesús Castañón et al. SLAS Discovery
- Randomness in DNA Encoded Library Selection Data Can Be Modeled for More Reliable Enrichment Calculation
- (2018) Letian Kuai et al. SLAS Discovery
- Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target
- (2018) Dean G. Brown et al. SLAS Discovery
- Addressing Cancer Chemotherapeutic Toxicity, Resistance, and Heterogeneity: Novel Theranostic Use of DNA-Encoded Small Molecule Libraries
- (2018) Gerald Kolodny et al. BIOESSAYS
- Dynamic Combinatorial Chemistry: A New Methodology Comes of Age
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- Predicting efficiency of NECEEM-based partitioning of protein binders from nonbinders in DNA-encoded libraries
- (2018) Sven Kochmann et al. ELECTROPHORESIS
- DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome
- (2018) Hans Richter et al. ACS Chemical Biology
- Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues
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- Quantitative assessment of affinity selection performance using DNA‐encoded chemical libraries
- (2018) Alessandro Sannino et al. CHEMBIOCHEM
- DNA-Encoded Dynamic Chemical Library and Its Applications in Ligand Discovery
- (2018) Yu Zhou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
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- In Vitro Selection of Diversely Functionalized Aptamers
- (2017) Dehui Kong et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection
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- Allosteric “beta-blocker” isolated from a DNA-encoded small molecule library
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- Affibody Molecules in Biotechnological and Medical Applications
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- A platform for high-throughput screening of DNA-encoded catalyst libraries in organic solvents
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- Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
- (2017) Carl A. Machutta et al. Nature Communications
- An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening
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- Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries
- (2017) Alexander L. Satz et al. ACS Combinatorial Science
- High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections
- (2016) Kimberly R. Mendes et al. ACS Chemical Biology
- Chemical Biology Probes from Advanced DNA-encoded Libraries
- (2016) Hazem Salamon et al. ACS Chemical Biology
- Predicting Electrophoretic Mobility of Protein–Ligand Complexes for Ligands from DNA-Encoded Libraries of Small Molecules
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- Drugging Membrane Protein Interactions
- (2016) Hang Yin et al. Annual Review of Biomedical Engineering
- Membrane proteins: always an insoluble problem?
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- Chemical Space of DNA-Encoded Libraries
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- Automated screening for small organic ligands using DNA-encoded chemical libraries
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- DNA-encoded chemistry: enabling the deeper sampling of chemical space
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- From haystack to needle: finding value with DNA encoded library technology at GSK
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- Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library
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- Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries
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- Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
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- DNA Encoded Library Selections and Insights Provided by Computational Simulations
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- Discovery in Droplets
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- Prediction of Protein–DNA Complex Mobility in Gel-Free Capillary Electrophoresis
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- DNA-Encoded Dynamic Combinatorial Chemical Libraries
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- Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
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- Structure, Dynamics, Assembly, and Evolution of Protein Complexes
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- Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins
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- Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery
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- Determination of equilibrium constant of amino carbamate adduct formation in sisomicin by a high pH based high performance liquid chromatography
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- Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
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- Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation
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- Design, preparation, and selection of DNA-encoded dynamic libraries
- (2015) Gang Li et al. Chemical Science
- Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor
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- DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis
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- DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries
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- Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets
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- Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists
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- Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates
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- Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
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- Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry
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- Aptamer-Based Affinity Labeling of Proteins
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- Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library
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- Encoded peptide libraries and the discovery of new cell binding ligands
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- Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands
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- Impact of high-throughput screening in biomedical research
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- Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds
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- Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library
- (2010) Luca Mannocci et al. BIOCONJUGATE CHEMISTRY
- Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library
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- In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors
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- Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment
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- Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition
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- A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution
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- Design, synthesis and selection of DNA-encoded small-molecule libraries
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- A Portable Albumin Binder from a DNA-Encoded Chemical Library
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- DNA-Encoded Chemical Libraries for the Discovery of MMP-3 Inhibitors
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- A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity
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- High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
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