期刊
ACS CHEMICAL BIOLOGY
卷 11, 期 2, 页码 296-307出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00981
关键词
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资金
- German Federal Ministry of Education and Research (BMBF) [131605]
The identification of bioactive compounds is a crucial step toward development of probes for chemical biology studies. Screening of DNA-encoded small molecule libraries (DELs) has emerged as a validated technology to interrogate vast chemical space. DELs consist of chimeric molecules composed of a low-molecular weight compound that is conjugated to a DNA identifier tag. They are screened as pooled libraries using selection to identify hits. Screening of DELs has identified numerous bioactive compounds. Some of these molecules were instrumental in gaining a deeper understanding of biological systems. One of the main challenges in the field is the development of synthesis methodology for DELs.
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