DNA-encoded chemical libraries - achievements and remaining challenges

DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

(2018) Dario Neri et al.   Annual Review of Biochemistry

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

(2018) Yizhou Li et al.   Nature Chemistry

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploration of a Au(i)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles

(2017) Mateja Klika Škopić et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures

(2017) Mateja Klika Škopić et al.   Chemical Science

Predicting Electrophoretic Mobility of Protein–Ligand Complexes for Ligands from DNA-Encoded Libraries of Small Molecules

(2016) Jiayin Bao et al.   ANALYTICAL CHEMISTRY

DNA-encoded chemical libraries: foundations and applications in lead discovery

(2016) Gunther Zimmermann et al.   DRUG DISCOVERY TODAY

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

(2016) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated screening for small organic ligands using DNA-encoded chemical libraries

(2016) Willy Decurtins et al.   Nature Protocols

DNA-encoded chemistry: enabling the deeper sampling of chemical space

(2016) Robert A. Goodnow et al.   NATURE REVIEWS DRUG DISCOVERY

Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library

(2016) L. K. Petersen et al.   MedChemComm

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure–Activity Relationships

(2016) Alexander L. Satz   ACS Combinatorial Science

What is a “DNA-Compatible” Reaction?

(2016) Marie L. Malone et al.   ACS Combinatorial Science

Systematic selection of modified aptamer pairs for diagnostic sandwich assays

(2016) Urs A. Ochsner et al.   BIOTECHNIQUES

A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution

(2016) Christoph Klenk et al.   Scientific Reports

DNA Encoded Library Selections and Insights Provided by Computational Simulations

(2015) Alexander L. Satz   ACS Chemical Biology

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries

(2015) Alexander Lee Satz et al.   BIOCONJUGATE CHEMISTRY

Novel selection methods for DNA-encoded chemical libraries

(2015) Alix I Chan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery

(2015) Peter Blakskjaer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

PNA-encoded chemical libraries

(2015) Claudio Zambaldo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

(2015) Moreno Wichert et al.   Nature Chemistry

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

(2015) Zining Wu et al.   ACS Combinatorial Science

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

(2015) Alexander Litovchick et al.   Scientific Reports

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of DNA-Conjugated Compounds Using a Regenerable Chip

(2014) Weilin Lin et al.   ANALYTICAL CHEMISTRY

Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

(2014) Peng Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

(2014) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

(2013) Gang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multistep DNA-Templated Synthesis Using a Universal Template

(2013) Yizhou Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library

(2012) Markus Leimbacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

(2012) Elisabet Wahlberg et al.   NATURE BIOTECHNOLOGY

Decoding a PNA Encoded Peptide Library by PCR: The Discovery of New Cell Surface Receptor Ligands

(2011) Nina Svensen et al.   CHEMISTRY & BIOLOGY

Drug Discovery with DNA-Encoded Chemical Libraries

(2010) Fabian Buller et al.   BIOCONJUGATE CHEMISTRY

High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries

(2010) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

(2010) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV

(2009) Katarzyna Gorska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA