Insulin action in adipocytes, adipose remodeling, and systemic effects

Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism

(2020) Xiao-Hong Wen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice

(2020) Melha Benlebna et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Visceral adipose tissue Tregs and the cells that nurture them

(2020) Chaoran Li et al.   IMMUNOLOGICAL REVIEWS

Triacylglycerol‐Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13‐DHAHLA) with Anti‐Inflammatory Properties in Mice

(2020) Veronika Paluchova et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice

(2020) Melha Benlebna et al.   EUROPEAN JOURNAL OF NUTRITION

Adipocyte Ceramides—The Nexus of Inflammation and Metabolic Disease

(2020) Bhagirath Chaurasia et al.   Frontiers in Immunology

Adipose Tissue Lipokines: Recent Progress and Future Directions

(2020) Veronica L. Li et al.   DIABETES

Associations between Fatty Acid-Binding Protein 4–A Proinflammatory Adipokine and Insulin Resistance, Gestational and Type 2 Diabetes Mellitus

(2019) Marcin Trojnar et al.   Cells

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

(2019) Adilson Guilherme et al.   Nature Reviews Endocrinology

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

(2019) Matthew J. Kolar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thirty sweet years of GLUT4

(2019) Amira Klip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

(2019) Ismail Syed et al.   JOURNAL OF CLINICAL INVESTIGATION

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms

(2019) Peng Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

(2019) Yvonne MH Bruls et al.   EBioMedicine

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

(2018) Ismail Syed et al.   Cell Metabolism

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice

(2018) Elsa Pflimlin et al.   Cell Metabolism

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

On the Complexity of PAHSA Research

(2018) Ondrej Kuda   Cell Metabolism

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects

(2018) Ismail Syed et al.   Cell Metabolism

Microfluidic-enabled quantitative measurements of insulin release dynamics from single islets of Langerhans in response to 5-palmitic acid hydroxy stearic acid

(2018) Basel Bandak et al.   LAB ON A CHIP

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids

(2018) Ann Hammarstedt et al.   Scientific Reports

9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway

(2018) Yan-Mei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating sphingolipids, fasting glucose, and impaired fasting glucose: The Strong Heart Family Study

(2018) Paul N. Jensen et al.   EBioMedicine

Plasticity of adipose tissue in response to fasting and refeeding in male mice

(2017) Hao-Neng Tang et al.   Nutrition & Metabolism

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

(2017) Maxwell A. Ruby et al.   Cell Reports

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

(2017) Archana Vijayakumar et al.   Cell Reports

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

(2016) Reema P. Vazirani et al.   DIABETES

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

(2016) Jennifer Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Acylcarnitines: potential implications for skeletal muscle insulin resistance

(2015) Céline Aguer et al.   FASEB JOURNAL

Macrophages and the Regulation of Adipose Tissue Remodeling

(2014) Gabriel Martinez-Santibañez et al.   Annual Review of Nutrition

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipose Tissue Foam Cells Are Present in Human Obesity

(2013) Hagit Shapiro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Decreased Transcription of ChREBP- /  Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia

(2012) R. Kursawe et al.   DIABETES

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

(2012) C. R. Bruce et al.   DIABETES

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice

(2012) Clinton R. Bruce et al.   ENDOCRINOLOGY

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism

(2012) Mark A. Herman et al.   NATURE

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat

(2010) Jennifer MacKellar et al.   PLoS One

Regional differences in cellular mechanisms of adipose tissue gain with overfeeding

(2010) Y. D. Tchoukalova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

Stranger in a strange land: Roles of glycogen turnover in adipose tissue metabolism

(2009) Kathleen R. Markan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways: Fig. 1.

(2008) Ira J. Goldberg et al.   JOURNAL OF LIPID RESEARCH