Article
Chemistry, Applied
Ran Bi, Lin Yue, Sobia Niazi, Imran Mahmood Khan, Dan Sun, Bin Wang, Zhouping Wang, Qixing Jiang, Wenshui Xia
Summary: A new chitosan oligosaccharide derivative modified with geraniol was synthesized and found to exhibit significant inhibitory effects on Escherichia coli and Staphylococcus aureus, with greater sensitivity towards S. aureus. The results support the potential application of COS derivatives as novel antibacterial agents in the food industry.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Jinxin Lan, Jiazhen Chen, Ruiqi Zhu, Changmei Lin, Xiaojuan Ma, Shilin Cao
Summary: Modified fibers with chitosan oligosaccharide were prepared and showed sustained antibacterial and antiviral performance. The fibers had washing durable activity and potential applications in protective clothing and hygiene products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaoxiang Han, Zhehao Zheng, Chen Yu, Yunli Deng, Qing Ye, Fuge Niu, Qing Chen, Weichun Pan, Yanbo Wang
Summary: In this study, ionized chitosan (ICS) was successfully synthesized from chitosan through methylation and sulfonation reactions. The modified ICS showed improved water solubility and antibacterial activity, indicating its potential as a water-soluble antibacterial agent.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Yanhui Kong, Wenjing Zhang, Tian He, Xue Yang, Wanghua Bi, Jiwei Li, Wenzhe Yang, Weichao Chen
Summary: In this study, a bilayered asymmetric nanofibrous membrane was prepared, with a hydrophilic chitosan/chitosan oligosaccharide (COS) nanofibrous membrane as the bottom layer and a hydrophobic polycaprolactone (PCL) nanofibrous membrane as the top layer. Results showed that incorporating COS improved the wettability of the CS membrane and increased the antibacterial effects against Escherichia coli and Staphylococcus aureus. The PCL layer prevented water and bacteria adhesion. This wettable membrane has the potential to serve as a new antibacterial dressing for wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Lin Yue, Min Wang, Imran Mahmood Khan, Jianguo Xu, Chifang Peng, Zhouping Wang
Summary: In this study, cinnamic acid conjugated hydroxypropyl chitosan derivatives with different degrees of substitution were successfully synthesized and showed good antibacterial activity against Staphylococcus aureus and Escherichia coli. The derivatives exhibited better water solubility than chitosan and had a significant inhibitory effect on biofilm formation. These results suggest the potential applicability of these derivatives in the treatment of biofilm-associated infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Riccardo Fontana, Peggy Carla Raffaella Marconi, Antonella Caputo, Vasak B. Gavalyan
Summary: This study focused on the antimicrobial activity of novel chitosan Schiff bases (CSSB) and found that their increased solubility greatly enhanced the inhibitory effects on both Gram-positive and Gram-negative bacteria as well as yeast, opening up new possibilities for antimicrobial prevention in fields such as food, cosmetics, and restoration.
Article
Chemistry, Applied
Wei Xia, Xiao-Yi Wei, Yuan-Yuan Xie, Tao Zhou
Summary: A novel thioether chitosan oligosaccharide (COS-All-Tio) with enhanced antioxidant and antibacterial activities was synthesized, and it showed no toxicity to cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Lingyu Zhao, Imran Mahmood Khan, Bin Wang, Lin Yue, Yin Zhang, Zhouping Wang, Wenshui Xia
Summary: The introduction of monomethyl fumaric acid (MFA) into chitosan oligosaccharide (COS) derivatives significantly enhances their antibacterial properties, suggesting a potential avenue for the development of novel antibacterial agents.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Lin Yue, Sobia Niazi, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: The study synthesized a novel hybrid flocculant with antibacterial activity, HTCC-CA, by conjugating cinnamic acid with HTCC. The results showed that HTCC-CA derivatives exhibited excellent flocculation efficiency and high antibacterial activity, making them promising agents for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Lin Yue, Min Wang, Imran Mahmood Khan, Sobia Niazi, Bin Wang, Xiaoyuan Ma, Zhouping Wang, Wenshui Xia
Summary: Novel chitosan oligosaccharide derivatives modified with cinnamyl onto the NH2 position were synthesized in a one-step reaction, and their in vitro antibacterial activities were greatly improved compared to COS, sodium benzoate, and potassium sorbate. The derivatives showed DS-dependent antibacterial activities, with a higher sensitivity to S. aureus than E. coli. This study demonstrated the potential of the new derivatives as promising antimicrobial agents in the food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuifang Mao, Xiaoli Liu, Wenshui Xia
Summary: This study modified chitosan oligosaccharide by grafting Linalool to enhance its anti-inflammatory activity, successfully synthesizing COS-g-Lin1-3 with improved thermal stability and anti-inflammatory properties. The derivatives showed more remarkable anti-inflammatory effects against hyaluronidase and collagenase, making them a promising compound for anti-inflammatory applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemes, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Virgil Musta
Summary: Chitosan and its derivatives have significant biomedical and therapeutic potential due to their natural origin, biocompatibility, biodegradability, and antibacterial properties. The antibacterial effect of chitosan is influenced by various factors, including its source, structure, chemical modifications, and target bacteria species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maysoon Abdulrahman Al-Zubairy, Khaled Hussein, Salwa H. Alkhyat, Abdullah Yahya Al-Mahdi, Saeed Munassar Alghalibi, Adel Ali Al-Gheethi, Muhanna Mohammed Al-Shaibani, Hesham Ali El Enshasy, Nik Marzuki Sidik
Summary: This study successfully characterized and predicted the antibacterial activity of a novel oligosaccharide from Streptomyces californics against Erwinia carotovora subsp. carotovora using an adaptive neuro-fuzzy inference system and an artificial neural network, providing new insights for potential antimicrobial agent research.
Article
Chemistry, Applied
Jianhui Li, Jimin Fu, Xiao Tian, Tao Hua, Tszyin Poon, Mingkin Koo, Wingming Chan
Summary: In this study, we characterized and analyzed eight types of chitosan fibers in terms of their composition, surface morphology, and mechanical properties. We also investigated the antibacterial activity of these fibers against Escherichia coli, Staphylococcus aureus, and Candida albicans, and examined the relationship between antibacterial activity and the molecular weight and degree of deacetylation. Additionally, we determined the antibacterial mechanism of chitosan fibers. The findings provide insights into the properties of chitosan fibers and offer effective strategies for enhancing their antibacterial activity and applications in antibacterial textiles.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
X-Y Wei, W. Xia, T. Zhou
Summary: The novel chitosan oligosaccharide derivative COS-All-Tio showed significantly improved antibacterial activity against six dominant spoilage bacteria, mainly by influencing membrane integrity to cause leakage of intracellular substances. When combined with food preservatives, COS-All-Tio exhibited a strong synergistic antibacterial effect against the spoilage bacteria.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Shan Xu, Peifang Chen, Xichi Lin, Imran Mahmood Khan, Xiaoyuan Ma, Zhouping Wang
Summary: In this study, a novel MOF-based SERS sensor was synthesized for the detection of histamine in fish products, exhibiting high sensitivity and stability. The core-shell structure of PVP-capped Au nanoflowers and ZIF-67 shell was controlled by adjusting the concentrations of PVP and MOF precursor Co ion. The Raman internal standard 4-MBA was used to eliminate signal fluctuations, and it showed specific recognition for histamine molecules. This work provides a facile strategy for the construction of MOF-based SERS substrates and has potential applications in predicting the shelf-life of fish products.
ANALYTICA CHIMICA ACTA
(2023)
Review
Food Science & Technology
Xiaoze Dong, Shuo Qi, Imran Mahmood Khan, Yuhan Sun, Yin Zhang, Zhouping Wang
Summary: This review discusses the latest developments in riboswitch-based biosensors for food safety detection, including their principles, design, and construction, as well as the applications of various riboswitch-based biosensors. In addition, the challenges and future prospects of riboswitch-based biosensors are summarized.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Chemistry, Inorganic & Nuclear
Imran Mahmood Khan, Sobia Niazi, Wasim Akhtar, Lin Yue, Imran Pasha, Muhammad Kashif Iqbal Khan, Ali Mohsin, Muhammad Waheed Iqbal, Yin Zhang, Zhouping Wang
Summary: Gold nanoclusters (AuNCs) are a versatile material with appealing properties, showing huge potential in the field of food safety. This review focuses on the development and application of AuNCs optical sensors, as well as their synthesis principle and sensing mechanism.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yan Lv, Yuhan Sun, You Zhou, Imran Mahmood Khan, Sobia Niazi, Lin Yue, Yin Zhang, Zhouping Wang
Summary: For the first time, the combination of CRISPR-Cas12a system, aptamer, cascaded dynamic DNA network circuits, and Fe3O4@hollow-TiO2@MoS2 nanochains (Fe3O4@h-TiO2@MoS2 NCs) is used to construct an efficient sensing platform for tetracycline (TC) analysis. This study demonstrates the specific recognition, transduction, and amplification of the target through the aptamer recognition module and dual amplification dynamic DNA network, leading to the recovery of the fluorescence signal. The synthesized multifunctional Fe3O4@h-TiO2@MoS2 NCs composites also exhibit magnetic separability and photocatalytic degradation ability.
Article
Materials Science, Biomaterials
Imran Mahmood Khan, Sobia Niazi, Imran Pasha, Muhammad Kashif Iqbal Khan, Lin Yue, Hua Ye, Ali Mohsin, Muhammad Shoaib, Yin Zhang, Zhouping Wang
Summary: In this study, fluorescent gold nanostructures were utilized to improve the detection sensitivity and specificity for T-2 toxin. The composite of AuNPs@PVP@RITC@SiO(2)NPs/rGO-AuNS served as a dual-mode fluorescence and surface-enhanced Raman scattering nanoprobe, achieving lower limits of detection of 85 pM and 12 pM, respectively.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Applied
Yi Zhang, Han-Jie Yang, Zhenghua Xu, Xiao Liu, Jie Zhou, Xu-Fang Qu, Wen-Long Wang, Yongwei Feng, Chifang Peng
Summary: In this study, an ultra-sensitive photothermal lateral flow immunoassay (LFIA) was developed for quantification of 17beta-estradiol (E2) in food and drinking water. The developed method demonstrated sensitivity over 100-fold higher than visual LFIA and a linear range of 3 orders of magnitude.
Article
Chemistry, Multidisciplinary
Xiuping Li, Fengxia Sun, Rui Chang, Zhengjun Xie, Chifang Peng, Yi Zhang, Zhouping Wang, Guodong Liu
Summary: The design of a versatile oligonucleotide lateral flow assay nanoprobe for small-molecule detection is reported in this study. By optimizing the length of the probe, a sensitive detection of the target small molecule is achieved. The universality of the strategy is also demonstrated.
Article
Chemistry, Analytical
Minxin Mao, Xiujin Chen, Yina Cai, Hanjie Yang, Cunzheng Zhang, Yi Zhang, Zhouping Wang, Chifang Peng
Summary: This study developed a portable rapid detection method based on triple helix aptamer and nanozyme, which can be used for the fast detection of small molecule contaminants. The results showed that this method can significantly accelerate the detection of acetamiprid and realize on-site quantitative detection in conjunction with a smartphone-based device. This strategy is expected to promote the application of aptamer-based rapid detection methods in the field of small molecule contaminants.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Min Li, Dayuan Wang, Chifang Peng, Zhouping Wang
Summary: A two-element based array (Al3+-CD@Cu and Mg2+-CD@Cu) was constructed for simultaneous identification of multiple flavonols by significant fluorescence emission enhancement. The sensor array successfully classified multiple flavonols in the samples using the SVM classification algorithm.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Shengmei Tai, Qiuli Pan, Xiujin Chen, Chifang Peng, Cunzheng Zhang, Zhouping Wang
Summary: A 3D porous cerium-doped graphene oxide nanoribbons with dual enzyme-like activities were prepared and used for the selective colorimetric detection of diafenthiuron and carbaryl. The detection method achieved a linear range of 10-1500 ng/mL for diafenthiuron and 2-800 ng/mL for carbaryl, with detection limits of 0.57 and 0.23 ng/mL, respectively. This work provides a new approach for developing highly sensitive and selective pesticide detection based on the direct inhibition of nanozyme activity through non-metal-sulfur bonding.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Guowen Li, Xiufang Huang, Chifang Peng, Fengxia Sun
Summary: Through optimizing the synthesis of silver nanoclusters (Ag NCs) using DNA templates, it was found that the fluorescence intensity of T base-extended DNA-templated Ag NCs was more than three times higher than C-riched DNA-templated Ag NCs. A turn-off fluorescence sensor based on the brightest DNA-Ag NCs was constructed for the sensitive detection of dimethoate, ethion, and phorate in lake water samples.
Article
Chemistry, Analytical
Xiujin Chen, Dong Gao, Jiaqi Chen, Xueqing Wang, Chifang Peng, Hongli Gao, Yao Wang, Zhaozhou Li, Huawei Niu
Summary: In this study, an electrochemical aptasensor using PAMAM dendrimers as a signal amplifier was developed for the sensitive detection of OTA. The aptasensor showed high sensitivity, specificity, and a broad linear detection range with a low detection limit. The proposed aptasensor was successfully applied for OTA analysis in red wine and demonstrated good recovery rates and storage stability.
Article
Food Science & Technology
Jinxiang Wei, Yifei He, Zhiyi Song, Imran Mahmood Khan, Zhouping Wang, Caiyun Jiang, Xiaoyuan Ma
Summary: A dual-signal aptasensor based on surface-enhanced Raman scattering (SERS) and fluorescence has been developed for the detection of aflatoxin B1. The sensor combines SERS and fluorescence signals through the functionalization of nanoparticles and aptamer, allowing for accurate detection of the target substance.
Article
Chemistry, Analytical
Mingwei Qin, Imran Mahmood Khan, Ning Ding, Yuhan Sun, Shuo Qi, Xiaoze Dong, Sobia Niazi, Yin Zhang, Zhouping Wang
Summary: In this study, the Capture-SELEX technology was used to isolate specific aptamers for capsaicin detection. A dual-mode colorimetric aptasensor was designed, which showed high sensitivity and a wide detection range for capsaicin in edible oils.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Food Science & Technology
Yunong Tang, Jinglei Yuan, Yin Zhang, Imran Mahmood Khan, Pengfei Ma, Zhouping Wang
Summary: Food safety has become a major concern in society, and food detection plays a crucial role in preventing food safety incidents. Lateral flow assay (LFA) is an efficient and rapid detection technology that offers an ideal platform for on-site detection. The combination of aptamers and nanoparticles in LFA presents both challenges and opportunities.
