Article
Biochemistry & Molecular Biology
Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Bin Wang, Xiaoyuan Ma, Chifang Peng, Zhouping Wang, Wenshui Xia
Summary: The present study synthesized a series of chitosan oligosaccharide-O-Terpenol derivatives and evaluated their in vitro antibacterial activity. These derivatives showed excellent solubility and antibacterial activity, with higher sensitivity to Staphylococcus aureus than Escherichia coli, suggesting their potential application as natural antibacterial agents. This study paves the way for expanding the application scope of COS and its derivatives in the food and pharmaceutical industries.
CARBOHYDRATE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jinxin Lan, Jiazhen Chen, Ruiqi Zhu, Changmei Lin, Xiaojuan Ma, Shilin Cao
Summary: Modified fibers with chitosan oligosaccharide were prepared and showed sustained antibacterial and antiviral performance. The fibers had washing durable activity and potential applications in protective clothing and hygiene products.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaoxiang Han, Zhehao Zheng, Chen Yu, Yunli Deng, Qing Ye, Fuge Niu, Qing Chen, Weichun Pan, Yanbo Wang
Summary: In this study, ionized chitosan (ICS) was successfully synthesized from chitosan through methylation and sulfonation reactions. The modified ICS showed improved water solubility and antibacterial activity, indicating its potential as a water-soluble antibacterial agent.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Yanhui Kong, Wenjing Zhang, Tian He, Xue Yang, Wanghua Bi, Jiwei Li, Wenzhe Yang, Weichao Chen
Summary: In this study, a bilayered asymmetric nanofibrous membrane was prepared, with a hydrophilic chitosan/chitosan oligosaccharide (COS) nanofibrous membrane as the bottom layer and a hydrophobic polycaprolactone (PCL) nanofibrous membrane as the top layer. Results showed that incorporating COS improved the wettability of the CS membrane and increased the antibacterial effects against Escherichia coli and Staphylococcus aureus. The PCL layer prevented water and bacteria adhesion. This wettable membrane has the potential to serve as a new antibacterial dressing for wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Lin Yue, Min Wang, Imran Mahmood Khan, Jianguo Xu, Chifang Peng, Zhouping Wang
Summary: In this study, cinnamic acid conjugated hydroxypropyl chitosan derivatives with different degrees of substitution were successfully synthesized and showed good antibacterial activity against Staphylococcus aureus and Escherichia coli. The derivatives exhibited better water solubility than chitosan and had a significant inhibitory effect on biofilm formation. These results suggest the potential applicability of these derivatives in the treatment of biofilm-associated infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Wei Xia, Xiao-Yi Wei, Yuan-Yuan Xie, Tao Zhou
Summary: A novel thioether chitosan oligosaccharide (COS-All-Tio) with enhanced antioxidant and antibacterial activities was synthesized, and it showed no toxicity to cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Lingyu Zhao, Imran Mahmood Khan, Bin Wang, Lin Yue, Yin Zhang, Zhouping Wang, Wenshui Xia
Summary: The introduction of monomethyl fumaric acid (MFA) into chitosan oligosaccharide (COS) derivatives significantly enhances their antibacterial properties, suggesting a potential avenue for the development of novel antibacterial agents.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Min Wang, Lin Yue, Sobia Niazi, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: The study synthesized a novel hybrid flocculant with antibacterial activity, HTCC-CA, by conjugating cinnamic acid with HTCC. The results showed that HTCC-CA derivatives exhibited excellent flocculation efficiency and high antibacterial activity, making them promising agents for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Lin Yue, Min Wang, Imran Mahmood Khan, Sobia Niazi, Bin Wang, Xiaoyuan Ma, Zhouping Wang, Wenshui Xia
Summary: Novel chitosan oligosaccharide derivatives modified with cinnamyl onto the NH2 position were synthesized in a one-step reaction, and their in vitro antibacterial activities were greatly improved compared to COS, sodium benzoate, and potassium sorbate. The derivatives showed DS-dependent antibacterial activities, with a higher sensitivity to S. aureus than E. coli. This study demonstrated the potential of the new derivatives as promising antimicrobial agents in the food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuifang Mao, Xiaoli Liu, Wenshui Xia
Summary: This study modified chitosan oligosaccharide by grafting Linalool to enhance its anti-inflammatory activity, successfully synthesizing COS-g-Lin1-3 with improved thermal stability and anti-inflammatory properties. The derivatives showed more remarkable anti-inflammatory effects against hyaluronidase and collagenase, making them a promising compound for anti-inflammatory applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Cristina Ardean, Corneliu Mircea Davidescu, Nicoleta Sorina Nemes, Adina Negrea, Mihaela Ciopec, Narcis Duteanu, Petru Negrea, Daniel Duda-Seiman, Virgil Musta
Summary: Chitosan and its derivatives have significant biomedical and therapeutic potential due to their natural origin, biocompatibility, biodegradability, and antibacterial properties. The antibacterial effect of chitosan is influenced by various factors, including its source, structure, chemical modifications, and target bacteria species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maysoon Abdulrahman Al-Zubairy, Khaled Hussein, Salwa H. Alkhyat, Abdullah Yahya Al-Mahdi, Saeed Munassar Alghalibi, Adel Ali Al-Gheethi, Muhanna Mohammed Al-Shaibani, Hesham Ali El Enshasy, Nik Marzuki Sidik
Summary: This study successfully characterized and predicted the antibacterial activity of a novel oligosaccharide from Streptomyces californics against Erwinia carotovora subsp. carotovora using an adaptive neuro-fuzzy inference system and an artificial neural network, providing new insights for potential antimicrobial agent research.
Article
Chemistry, Applied
Jianhui Li, Jimin Fu, Xiao Tian, Tao Hua, Tszyin Poon, Mingkin Koo, Wingming Chan
Summary: In this study, we characterized and analyzed eight types of chitosan fibers in terms of their composition, surface morphology, and mechanical properties. We also investigated the antibacterial activity of these fibers against Escherichia coli, Staphylococcus aureus, and Candida albicans, and examined the relationship between antibacterial activity and the molecular weight and degree of deacetylation. Additionally, we determined the antibacterial mechanism of chitosan fibers. The findings provide insights into the properties of chitosan fibers and offer effective strategies for enhancing their antibacterial activity and applications in antibacterial textiles.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
X-Y Wei, W. Xia, T. Zhou
Summary: The novel chitosan oligosaccharide derivative COS-All-Tio showed significantly improved antibacterial activity against six dominant spoilage bacteria, mainly by influencing membrane integrity to cause leakage of intracellular substances. When combined with food preservatives, COS-All-Tio exhibited a strong synergistic antibacterial effect against the spoilage bacteria.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Biophysics
Jiahao Xu, Jiayi Lian, Lijun You, Zhengang Zhao
Summary: In this study, a modified chitosan was synthesized to serve as a carrier for encapsulating hydrophilic nutraceuticals such as betanin. The modified chitosan exhibited good encapsulation ability, antioxidant activity, and antibacterial properties, making it a promising option for inhibiting spoilage bacteria in food.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Food Science & Technology
Bilal Sajid Mushtaq, Wenhui Zhang, Waleed Al-Ansi, Faizan Ul Haq, Abdur Rehman, Rabia Omer, Imran Mahmood Khan, Sobia Niazi, Aqsa Ahmad, Amer Ali Mahdi, Qais Ali Al-Maqtari, Noman Walayat, Li Wang
Summary: The prevalence of celiac disease (CD) and other gluten-intolerant disorders is increasing, especially in developed countries. This has led to a growing demand for gluten-free (GF) food products, which are seen as profitable therapy for gluten-related disorders. The use of extrusion cooking, an emerging processing technique, is becoming popular in the food industry for the development of a wide range of GF-based products with different shapes and improved characteristics. However, there are challenges in terms of starch-protein interaction, chemical structure capability, and texture, nutritional, and sensory characteristics that need to be addressed for successful GF food processing.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Hua Ye, Zhixin Yang, Imran Mahmood Khan, Sobia Niazi, Yuanxin Guo, Zhouping Wang, Hongshun Yang
Summary: Antibiotic contamination is a global issue and there is a need for sensitive, specific and simple technology for antibiotic detection. Biosensors based on split aptamers have gained extensive attention due to their higher sensitivity, lower cost, false positive/negative avoidance and flexibility in sensor design. However, the acquisition and mechanism of splitting antibiotic aptamers are still unknown.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Physical
Shuo Qi, Yuhan Sun, Xiaoze Dong, Imran Mahmood Khan, Yan Lv, Yin Zhang, Nuo Duan, Shijia Wu, Zhouping Wang
Summary: In this study, a 3D DNA nanomotor biosensor powered by DNAzyme and entropy-driven circuit was developed for sensitive and specific detection of lysozyme using bispecific aptamer as initiators. This biosensor integrates walking and rolling strategies to achieve excellent signal amplification capability. It can respond to lysozyme with high specificity and operate at high speed to release signals, independent of protease. The biosensor shows a detection limit of 0.01 pg/mL and a linear range of 0.05 pg/mL-500 ng/mL for lysozyme, and exhibits high accuracy in the analysis of real samples, indicating its great potential for non-nucleic acid target detection.
Article
Chemistry, Analytical
Shan Xu, Peifang Chen, Xichi Lin, Imran Mahmood Khan, Xiaoyuan Ma, Zhouping Wang
Summary: In this study, a novel MOF-based SERS sensor was synthesized for the detection of histamine in fish products, exhibiting high sensitivity and stability. The core-shell structure of PVP-capped Au nanoflowers and ZIF-67 shell was controlled by adjusting the concentrations of PVP and MOF precursor Co ion. The Raman internal standard 4-MBA was used to eliminate signal fluctuations, and it showed specific recognition for histamine molecules. This work provides a facile strategy for the construction of MOF-based SERS substrates and has potential applications in predicting the shelf-life of fish products.
ANALYTICA CHIMICA ACTA
(2023)
Review
Food Science & Technology
Xiaoze Dong, Shuo Qi, Imran Mahmood Khan, Yuhan Sun, Yin Zhang, Zhouping Wang
Summary: This review discusses the latest developments in riboswitch-based biosensors for food safety detection, including their principles, design, and construction, as well as the applications of various riboswitch-based biosensors. In addition, the challenges and future prospects of riboswitch-based biosensors are summarized.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Chemistry, Inorganic & Nuclear
Imran Mahmood Khan, Sobia Niazi, Wasim Akhtar, Lin Yue, Imran Pasha, Muhammad Kashif Iqbal Khan, Ali Mohsin, Muhammad Waheed Iqbal, Yin Zhang, Zhouping Wang
Summary: Gold nanoclusters (AuNCs) are a versatile material with appealing properties, showing huge potential in the field of food safety. This review focuses on the development and application of AuNCs optical sensors, as well as their synthesis principle and sensing mechanism.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yan Lv, Yuhan Sun, You Zhou, Imran Mahmood Khan, Sobia Niazi, Lin Yue, Yin Zhang, Zhouping Wang
Summary: For the first time, the combination of CRISPR-Cas12a system, aptamer, cascaded dynamic DNA network circuits, and Fe3O4@hollow-TiO2@MoS2 nanochains (Fe3O4@h-TiO2@MoS2 NCs) is used to construct an efficient sensing platform for tetracycline (TC) analysis. This study demonstrates the specific recognition, transduction, and amplification of the target through the aptamer recognition module and dual amplification dynamic DNA network, leading to the recovery of the fluorescence signal. The synthesized multifunctional Fe3O4@h-TiO2@MoS2 NCs composites also exhibit magnetic separability and photocatalytic degradation ability.
Article
Engineering, Environmental
Yan Lv, Yuhan Sun, Imran Mahmood Khan, Qiaofeng Li, You Zhou, Lin Yue, Yin Zhang, Zhouping Wang
Summary: A turn-on fluorescence aptasensor based on entropy-driven catalysis (EDC) and CRISPR-Cas12a was developed for the sensitive determination of sulfadimethoxine (SDM). A novel EDC circuit was designed to lock the activation sequence of CRISPR-Cas12a, and H-Fe3O4@MoS2 microsphere was used as a fluorescence resonance energy transfer (FRET) acceptor for quenching the fluorescence of ssDNA-FAM. The developed aptasensor showed excellent analytical performance with a wide dynamic range and low detection limit.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Lehan Zhao, Xianfeng Lin, Nuo Duan, Imran Mahmood Khan, Zhouping Wang, Shijia Wu
Summary: In this study, a one-pot reverse microemulsion polymerization was used to synthesize an efficient fluorescent hybrid probe (AuNCs@COFs@MIPs), which combined gold nanoclusters (AuNCs) with molecularly imprinted polymers (MIPs) and covalent organic frameworks (COFs), for selective detection of malachite green (MG). The probe showed specific recognition towards MG and triggered fluorescence quenching of AuNCs. The fluorescent response was linearly related to the concentration of MG and the probe exhibited a promising application for detecting residue of veterinary drugs in fish and water samples with a favorable recovery.
Article
Food Science & Technology
Zixuan Shang, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: A DNA tweezers fluorescence aptasensor based on split aptamer assisted-magnetic nanoparticles and magnetic separation was developed for the detection of Enrofloxacin. The aptasensor exhibited a turn-on and turn-off fluorescence signal in the presence and absence of ENR, respectively. The method showed a wide detection range and good performance in spiked milk samples.
Article
Food Science & Technology
Jinxiang Wei, Yifei He, Zhiyi Song, Imran Mahmood Khan, Zhouping Wang, Caiyun Jiang, Xiaoyuan Ma
Summary: A dual-signal aptasensor based on surface-enhanced Raman scattering (SERS) and fluorescence has been developed for the detection of aflatoxin B1. The sensor combines SERS and fluorescence signals through the functionalization of nanoparticles and aptamer, allowing for accurate detection of the target substance.
Article
Food Science & Technology
Yunong Tang, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang
Summary: This paper reports a turn on mode aptamer sensor for AFB1 detection using gold nanoparticles. The detection results are proportional to the concentration of AFB1, which is in line with human intuitions. This development provides a novel design idea for the detection of small molecules such as mycotoxins.
Article
Food Science & Technology
Yunong Tang, Jinglei Yuan, Yin Zhang, Imran Mahmood Khan, Pengfei Ma, Zhouping Wang
Summary: Food safety has become a major concern in society, and food detection plays a crucial role in preventing food safety incidents. Lateral flow assay (LFA) is an efficient and rapid detection technology that offers an ideal platform for on-site detection. The combination of aptamers and nanoparticles in LFA presents both challenges and opportunities.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
