Hierarchical responsive micelle facilitates intratumoral penetration by acid-activated positive charge surface and size contraction

A Hypoxia‐Responsive Albumin‐Based Nanosystem for Deep Tumor Penetration and Excellent Therapeutic Efficacy

(2019) Guangbao Yang et al.   ADVANCED MATERIALS

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy

(2019) Weiwei Cao et al.   CHEMICAL ENGINEERING JOURNAL

Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance

(2019) Ranjith Kumar Kankala et al.   CHEMICAL ENGINEERING JOURNAL

Engineered nanomedicines with enhanced tumor penetration

(2019) Jianxun Ding et al.   Nano Today

Multistage tumor microenvironment-responsive theranostic nanopeanuts: Toward multimode imaging guided chemo-photodynamic therapy

(2019) Xunan Jing et al.   CHEMICAL ENGINEERING JOURNAL

Near-Infrared-Light-Activatable Nanomaterial-Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

(2018) Raviraj Vankayala et al.   ADVANCED MATERIALS

Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer

(2018) Xiao Zhang et al.   ADVANCED MATERIALS

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

(2018) Giancarlo Canavese et al.   CHEMICAL ENGINEERING JOURNAL

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Hierarchical Tumor Microenvironment-Responsive Nanomedicine for Programmed Delivery of Chemotherapeutics

(2018) Sheng Wang et al.   ADVANCED MATERIALS

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

(2018) Xuexiang Han et al.   Nature Communications

Tumor-Acidity-Cleavable Maleic Acid Amide (TACMAA): A Powerful Tool for Designing Smart Nanoparticles To Overcome Delivery Barriers in Cancer Nanomedicine

(2018) Jin-Zhi Du et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stimuli-Responsive Nano-Architecture Drug-Delivery Systems to Solid Tumor Micromilieu: Past, Present, and Future Perspectives

(2018) Hossam S. El-Sawy et al.   ACS Nano

Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy

(2017) Xiaoding Xu et al.   NANO LETTERS

Reduction-Degradable Polymeric Micelles Decorated with PArg for Improving Anticancer Drug Delivery Efficacy

(2016) Yani Cui et al.   ACS Applied Materials & Interfaces

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

Ambient Aqueous Synthesis of Ultrasmall PEGylated Cu2−xSe Nanoparticles as a Multifunctional Theranostic Agent for Multimodal Imaging Guided Photothermal Therapy of Cancer

(2016) Shaohua Zhang et al.   ADVANCED MATERIALS

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

(2016) Manju Kanamala et al.   BIOMATERIALS

Sonoporation enhances liposome accumulation and penetration in tumors with low EPR

(2016) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

Ultrasensitive pH Triggered Charge/Size Dual-Rebound Gene Delivery System

(2016) Xiuwen Guan et al.   NANO LETTERS

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

(2016) Quanyin Hu et al.   NANO LETTERS

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction

(2015) Mary M. Nguyen et al.   ADVANCED MATERIALS

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

(2015) Sijumon Kunjachan et al.   NANO LETTERS

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Biodistribution of Different Sized Nanoparticles Assessed by Positron Emission Tomography: A General Strategy for Direct Activation of Metal Oxide Particles

(2013) Carlos Pérez-Campaña et al.   ACS Nano

Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells

(2011) Kejin Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

(2011) Kai Xiao et al.   BIOMATERIALS

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Charge-Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery

(2009) Zhuxian Zhou et al.   ADVANCED FUNCTIONAL MATERIALS

Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties

(2009) Lars Linderoth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion

(2008) Zih-rou HUANG et al.   ACTA PHARMACOLOGICA SINICA