Article
Biochemistry & Molecular Biology
Yanxia Fu, Jun Li, Ziyu Zhang, Fangli Ren, Yinyin Wang, Huihui Jia, Jihe Liu, Zhijie Chang
Summary: Exosomes derived from human umbilical cord MSCs (HUMSCs) have immunoregulatory functions in rheumatoid arthritis, reducing swelling and inflammation levels, and restoring the balance between Th17 and Treg cells.
Article
Pharmacology & Pharmacy
Xuan Zhao, Chengyuan Huang, Meiling Su, Yu Ran, Ying Wang, Zongning Yin
Summary: The study demonstrated that CLT/BRNP exhibits significant anti-arthritic effects in the treatment of rheumatoid arthritis, and has lower toxic effects compared to free celastrol.
Review
Engineering, Biomedical
Eun Sook Lee, Hyewon Ko, Chan Ho Kim, Hyun-Chul Kim, Seong-Kyoon Choi, Sang Won Jeong, Se-Guen Lee, Sung-Jun Lee, Hee-Kyung Na, Jae Hyung Park, Jung Min Shin
Summary: This review introduces the potential of exosomes as biomarkers and drug delivery systems, with a focus on their application in treating rheumatoid arthritis. It also suggests pre/post-engineering approaches to overcome their limitations.
BIOMATERIALS RESEARCH
(2023)
Article
Plant Sciences
Meng Meng, Lianfu Wang, Yang Yao, Dongmei Lin, Changyuan Wang, Jialin Yao, Huijun Sun, Mozhen Liu
Summary: This study found that Ganoderma lucidum polysaccharide peptide (GLPP) can effectively alleviate symptoms of arthritis and exert its effects by inhibiting the NF-kappa B and MAPK pathways. This provides evidence for the potential therapeutic effect of mushroom-derived polysaccharide peptides in the treatment of rheumatoid arthritis (RA).
Review
Immunology
Sicheng Zhang, Zhen Duan, Fang Liu, Qingjie Wu, Xiwei Sun, Hailong Ma
Summary: Rheumatoid arthritis (RA) is an autoimmune disease that affects joint health. Exosomes, which are secreted vesicles, contain various substances and play a role in cellular communication. Recent studies have shown that exosomes derived from different cells can influence the biological functions of immune cells and joint cells, but the exact mechanisms are still unclear. This comprehensive review provides a scientific foundation for utilizing exosomes as diagnostic targets and therapeutic approaches in the context of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jia Wang, Sheng-Xiao Zhang, Jia-Song Chang, Ting Cheng, Xiao-Jing Jiang, Qin-Yi Su, Jia-Qi Zhang, Jing Luo, Xiao-Feng Li
Summary: This study investigated the status of CD4(+) Tregs and the effects of low-dose IL-2 therapy in patients with refractory rheumatoid arthritis (RA). The results showed that a decrease in the absolute number of CD4 Tregs, rather than an increase in Th17 cells, contributed to an imbalance and high disease activity. Low-dose IL-2 selectively increased CD4 Tregs and rebalanced the ratio of Th17 and CD4 Tregs, leading to symptom remission without side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jian-Fang Xie, Jia Wang, Huan-Huan Bai, Jiao-Jiao He, Rui-Huan Jia, Xia Wang, Wen-Qi Zhang, Xiang-Cong Zhao, Xian-Cheng Zhang, Guang-Ying Liu, Xiao-Feng Li
Summary: This study suggests that serum OPN levels are higher in patients with active and refractory RA compared to healthy controls. In active RA patients, there is an increase in Th2 cells and a decrease in Th1 and T-reg cells. As the disease condition worsens, OPN levels increase while the counts of Th1 and T-reg cells decrease. Patients with high disease activity show the lowest counts of Th1 and T-reg cells and the highest OPN levels. The serum OPN level is significantly negatively correlated with the counts of T-reg cells in CD4(+) T lymphocyte subsets.
ADVANCES IN THERAPY
(2022)
Article
Cell & Tissue Engineering
Shichong Wang, Jiali Huo, Yilin Liu, Lingyun Chen, Xiang Ren, Xingxin Li, Min Wang, Peng Jin, Jinbo Huang, Neng Nie, Jing Zhang, Yingqi Shao, Meili Ge, Yizhou Zheng
Summary: This study revealed that AA-Exos had impaired immunosuppressive effects on CD3 + T cells, less ability to rescue AA mice, and differentially expressed miRNA profiles. This may partly explain the pathogenesis of AA and provide a new target for AA treatment.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Immunology
Bo Zhang, Ming Zhao, Qianjin Lu
Summary: Extracellular vesicles (EVs) have attracted wide interest in basic and clinical research in the past two decades. They are small membrane vesicles released by almost all cells and play important roles in immunomodulation and the pathogenesis of autoimmune diseases, showing great potential in the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Qisong Liu, Defeng Li, Xiaohua Pan, Yujie Liang
Summary: Extracellular vesicles (EVs) are membrane-bound vesicles naturally secreted by cells, which play important roles in intercellular communication by delivering regulatory molecules. EVs possess desirable properties and can be used as therapeutic delivery vehicles. Surface modifications can endow EVs with targeting abilities, significantly improving therapeutic efficiency. EVs hold great promise for targeted delivery and treatment of various diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ting-Hui Chang, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang, Hsiu-Jung Liao
Summary: This review summarizes the current knowledge of ADSC-based therapy and ADSC-Exos for the treatment of rheumatoid arthritis (RA), discussing their immunomodulatory and anti-inflammatory properties.
Article
Immunology
Yuting Wang, Yurong Huang, Chenglong Cheng, Qiuyun Xue, Jun Chang, Xiao Wang, Qiangjun Duan, Chenggui Miao
Summary: This article summarizes the role of circulating RNAs (circRNAs) in the pathogenesis of rheumatoid arthritis (RA). It found that the abnormal expression of circRNAs and their sponge effect on microRNAs (miRNAs) affect the pathogenesis of RA by regulating target genes. Moreover, the presence of circRNAs in exosomes and their relationship with RNA methylations are closely related to the pathogenesis of RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Lixin Huang, Ling Liang, Zhuyi Ji, Shuyang Chen, Meng Liu, Qidang Huang, Zhixiang Huang, Shanmiao Sun, Jiali Ding, Jiajun Chen, Xuechan Huang, Shaoling Zheng, Weiming Deng, Yukai Huang, Tianwang Li
Summary: Proteomic analysis of CD4+ T-cell-derived exosomes from patients with rheumatoid arthritis (RA) revealed differential expression of proteins involved in gene regulation, antigen processing, acute-phase response, and PI3K-AKT signaling pathways. ELISA validation confirmed significant upregulation of DPYSL3 and downregulation of PSME1 in CD4+ T-cell-derived exosomes from the RA group. These findings suggest that DPYSL3 and PSME1 may serve as potential biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemical Research Methods
Zahra Payandeh, Abbas Pirpour Tazehkand, Ali Azargoonjahromi, Faezeh Almasi, Armina Alagheband Bahrami
Summary: Auto-immune diseases affect a significant portion of the population in wealthy countries, with Rheumatoid Arthritis being a common autoimmune disease. This condition can lead to synovial inflammation and joint injury, and exosomes have emerged as potential therapeutic vectors for treating such diseases.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Immunology
Seyeon Bae, Kibyeong Kim, Keunsoo Kang, Haemin Kim, Minjoon Lee, Brian Oh, Kaichi Kaneko, Sungkook Ma, Jae Hoon Choi, Hojoong Kwak, Eun Young Lee, Sung Ho Park, Kyung-Hyun Park-Min
Summary: Monocyte/macrophage lineage cells are capable of differentiating into various cells. RANKL induces the differentiation of monocyte/macrophage lineage into bone-resorbing osteoclasts. However, the epigenetic mechanisms underlying this differentiation process in human osteoclasts are not well understood.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dong Gil You, Jae Yoon An, Wooram Um, Jae Min Jung, Byeong Hoon Oh, Van Quy Nguyen, Jueun Jeon, Jungmi Lee, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: Hyaluronic acid-based hydrogels have the potential to reduce wrinkles, while stem cell-derived extracellular vesicles can improve the dermal microenvironment, prolong collagen generation, and serve as a potential antiaging filler for reprogramming the dermis environment.
Article
Biochemistry & Molecular Biology
Yiran Liu, David Castano, Francesco Girolamo, Laia Trigueros-Motos, Han-Gyu Bae, Suat Peng Neo, Jeongah Oh, Pradeep Narayanaswamy, Federico Torta, Kerry Anne Rye, Dong-Gyu Jo, Jayantha Gunaratne, Sangyong Jung, Daniela Virgintino, Roshni R. Singaraja
Summary: The lack of ABCA8 protein disrupts cerebellar myelination and affects the function of oligodendrocyte precursor cells and mature oligodendrocytes, leading to impaired cerebellar conduction velocity and locomotion.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Neurosciences
Luting Poh, Wei Liang Sim, Dong-Gyu Jo, Quynh Nhu Dinh, Grant R. Drummond, Christopher G. Sobey, Christopher Li-Hsian Chen, Mitchell K. P. Lai, David Y. Fann, Thiruma V. Arumugam
Summary: This review aims to provide a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of chronic cerebral hypoperfusion-induced inflammasome signaling in vascular cognitive impairment (VCI).
MOLECULAR NEURODEGENERATION
(2022)
Article
Biochemistry & Molecular Biology
Joo-Yun Byun, Kun Huang, Jong Suk Lee, Wenjie Huang, Li Hu, Xuyu Zheng, Xin Tang, Fengzeng Li, Dong-Gyu Jo, Xinmao Song, Chuang Huang
Summary: Poor prognosis of head and neck squamous cell carcinomas (HNSCCs) is mainly due to resistance to chemotherapy and radiotherapy. Activation of HIF-1 alpha in CD44(+) HNSCC patients was associated with worse prognosis. HIF-1 alpha promoted stemness, resistance, and epithelial-mesenchymal transition in HNSCC CD44(+) cells.
Article
Multidisciplinary Sciences
Ziyuan Jiang, Jiajin Li, Nahyun Kong, Jeong-Hyun Kim, Bong-Soo Kim, Min-Jung Lee, Yoon Mee Park, So-Yeon Lee, Soo-Jong Hong, Jae Hoon Sul
Summary: We developed an accurate and automated pipeline for diagnosing atopic dermatitis (AD) based on transcriptome and microbiota data. Our findings suggest that certain genes and microbiota features may serve as useful biomarkers for predicting AD.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Hark Kyun Kim, Junhyung Cho, Eunae Kim, Junsik Kim, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Younmin Shin, Leon F. Palomera, Jinsu Park, Seung Hyun Baek, Han-Gyu Bae, Yoonsuk Cho, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Jae Hyung Park, Yong Woo Cho, Wonsik Lee, Dong-Gyu Jo
Summary: This study presents a method of using small extracellular vesicles (sEVs) to deliver soluble ACE2 (sACE2) and inhibit the entry of SARS-CoV-2. The researchers found that sACE2 variants loaded in sEVs showed higher antiviral efficacy compared to wild-type sACE2, and could inhibit the entry of different variants of SARS-CoV-2.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Geriatrics & Gerontology
Gavin Yong-Quan Ng, Dominic Paul Lee Kok Sheng, Han-Gyu Bae, Sung Wook Kang, David Yang-Wei Fann, Jinsu Park, Joonki Kim, Asfa Alli-Shaik, Jeongmi Lee, Eunae Kim, Sunyoung Park, Jeung-Whan Han, Vardan Karamyan, Eitan Okun, Thameem Dheen, Manoor Prakash Hande, Raghu Vemuganti, Karthik Mallilankaraman, Lina H. K. Lim, Brian K. Kennedy, Grant R. Drummond, Christopher G. Sobey, Jayantha Gunaratne, Mark P. Mattson, Roger Sik-Yin Foo, Dong-Gyu Jo, Thiruma V. Arumugam
Summary: Intermittent fasting can modulate H3K9 trimethylation in the cerebellum and trigger transcriptomic changes associated with metabolic processes. Part of the epigenomic and transcriptomic modulations induced by IF can be preserved for at least 3 months post-IF, but termination of IF results in a loss of H3K9 trimethylation regulation of the transcriptome.
Review
Pharmacology & Pharmacy
Yoonsuk Cho, Han-Gyu Bae, Eitan Okun, Thiruma V. Arumugam, Dong-Gyu Jo
Summary: APP is an evolutionarily conserved transmembrane protein that serves as a precursor to amyloid-beta peptides, which are implicated in Alzheimer's disease. Studies have shown diverse pathological and physiological functions of APP and its cleavage products, but their roles are not fully understood. Current research focuses on APP processing and potential therapeutic approaches for Alzheimer's disease.
PHARMACOLOGY & THERAPEUTICS
(2022)
Correction
Pharmacology & Pharmacy
Yoonsuk Cho, Han-Gyu Bae, Eitan Okun, Thiruma V. Arumugam, Dong-Gyu Jo
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Genetics & Heredity
Ruth Johnson, Yi Ding, Vidhya Venkateswaran, Arjun Bhattacharya, Kristin Boulier, Alec Chiu, Sergey Knyazev, Tommer Schwarz, Malika Freund, Lingyu Zhan, Kathryn S. Burch, Christa Caggiano, Brian Hill, Nadav Rakocz, Brunilda Balliu, Christopher T. Denny, Jae Hoon Sul, Noah Zaitlen, Valerie A. Arboleda, Eran Halperin, Sriram Sankararaman, Manish J. Butte, Clara Lajonchere, Daniel H. Geschwind, Bogdan Pasaniuc
Summary: This study explores the interplay between genetic ancestry and social determinants of health within the University of California, Los Angeles (UCLA) ATLAS Community Health Initiative. The researchers find that self-identified race/ethnicity is highly correlated with genetically inferred ancestry, but there are still marked differences between the two. Additionally, the study demonstrates the utility of genetic data linked with electronic health records for performing multi-ancestry genome and phenome-wide scans across a broad set of disease phenotypes.
Article
Biochemistry & Molecular Biology
Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Park
Summary: Spatial learning and memory flexibility are regulated by long-term potentiation (LTP) and long-term depression (LTD) at the cellular level. This study demonstrates that Ccny knockout (KO) mice exhibit enhanced LTP, weak LTD, and improved spatial learning and memory. CCNY modulates memory flexibility by modulating the cofilin-actin signaling pathway in the hippocampus.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Vismitha Rajeev, David Y. Fann, Quynh Nhu Dinh, Hyun Ah Kim, T. Michael De Silva, Dong-Gyu Jo, Grant R. Drummond, Christopher G. Sobey, Mitchell K. P. Lai, Christopher Li-Hsian Chen, Thiruma V. Arumugam
Summary: Chronic cerebral hypoperfusion (CCH) is an important mechanism in vascular cognitive impairment (VCI). Intermittent fasting (IF) has neuroprotective effects against CCH-induced neurovascular pathologies by reducing leaky microvessels, blood-brain barrier breakdown, and loss of tight junctional proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Meeting Abstract
Genetics & Heredity
Ichcha Manipur, Jae-Hoon Sul, Simonne Longerich, Adrian Cortes, Chris Wallace
Article
Genetics & Heredity
Sarah J. Spendlove, Leroy Bondhus, Gentian Lluri, Jae Hoon Sul, Valerie A. Arboleda
Summary: Congenital heart disease (CHD) is a rare structural defect, and common genetic variants have a modest but significant contribution to the phenotypic expression of CHD.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)