Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Uncovering the Hidden Antibiotic Potential of Cannabis

(2020) Maya A. Farha et al.   ACS Infectious Diseases

Genetic and Chemical-Genetic Interactions Map Biogenesis and Permeability Determinants of the Outer Membrane of Escherichia coli

(2020) Kristina Klobucar et al.   mBio

Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance

(2020) Craig R. MacNair et al.   mBio

Polymyxin Derivatives that Sensitize Gram-Negative Bacteria to Other Antibiotics

(2019) Martti Vaara   MOLECULES

Polymyxin B analog SPR741 potentiates antibiotics against Gram-negative bacteria and uniquely perturbs the outer membrane

(2019) Shawn French et al.   ACS Infectious Diseases

The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii

(2018) Jonathan M. Tyrrell et al.   PEPTIDES

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

(2017) Jonathan M. Stokes et al.   Nature Microbiology

Breaking the permeability barrier ofEscherichia coliby controlled hyperporination of the outer membrane.

(2016) Ganesh Krishnamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment of Gram-negative bacterial infections by potentiation of antibiotics

(2016) Thomas P Zabawa et al.   CURRENT OPINION IN MICROBIOLOGY

Quinoxaline, its derivatives and applications: A State of the Art review

(2015) Joana A. Pereira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane inEscherichia coli

(2015) Matthias Urfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DataWarrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis

(2015) Thomas Sander et al.   Journal of Chemical Information and Modeling

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Divalent Cation Removal on the Structure of Gram-Negative Bacterial Outer Membrane Models

(2014) Luke A. Clifton et al.   LANGMUIR

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

(2014) Jonathan M Stokes et al.   eLife

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Genomic Approaches to Study Model Microbes

(2010) Courtney A. Barker et al.   CHEMISTRY & BIOLOGY

Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity

(2010) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY