Mechanism-Guided Development of Transition-Metal-Catalyzed C–N Bond-Forming Reactions Using Dioxazolones as the Versatile Amidating Source

Tuning Orbital Symmetry of Iridium Nitrenoid Enables Catalytic Diastereo- and Enantioselective Alkene Difunctionalizations

(2021) Suhyeon Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Access to Spirolactams via Nitrenoid Transfer Enabled by Enhanced Noncovalent Interactions

(2021) Euijae Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Merging NiH Catalysis and Inner-Sphere Metal-Nitrenoid Transfer for Hydroamidation of Alkynes

(2021) Xiang Lyu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative Analysis on Two-Point Ligand Modulation of Iridium Catalysts for Chemodivergent C–H Amidation

(2020) Yeongyu Hwang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dioxazolones: Stable Substrates for the Catalytic Transfer of Acyl Nitrenes

(2020) Kaj M. van Vliet et al.   ACS Catalysis

Designing a Planar Chiral Rhodium Indenyl Catalyst for Regio- and Enantioselective Allylic C–H Amidation

(2020) Caitlin M. B. Farr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes

(2020) Honghui Lei et al.   Nature Chemistry

Dual-Ligand-Enabled Ir(III)-Catalyzed Enantioselective C–H Amidation for the Synthesis of Chiral Sulfoxides

(2020) Wentan Liu et al.   ACS Catalysis

Highly Robust Iron Catalyst System for Intramolecular C(sp 3 )−H Amidation Leading to γ‐Lactams

(2020) Jeonguk Kweon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide Late-Stage Diversifications by Rhodium-Catalyzed Tryptophan C7 Amidation

(2020) Wei Wang et al.   Chem

Catalytic access to carbocation intermediates via nitrenoid transfer leading to allylic lactams

(2020) Seung Youn Hong et al.   Nature Catalysis

Ruthenium(II)-Catalyzed Enantioselective γ-Lactams Formation by Intramolecular C–H Amidation of 1,4,2-Dioxazol-5-ones

(2019) Qi Xing et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ir-Catalyzed Intermolecular Branch-Selective Allylic C–H Amidation of Unactivated Terminal Olefins

(2019) Honghui Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular, Branch-Selective and Redox-Neutral Cp*IrIII-Catalyzed Allylic C-H Amidation

(2019) Tobias Knecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Enantioselective C(sp3)–H Amidation Controlled by Attractive Noncovalent Interactions

(2019) Hao Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh(III) and Ir(III)Cp* Complexes Provide Complementary Regioselectivity Profiles in Intermolecular Allylic C–H Amidation Reactions

(2019) Jacob S. Burman et al.   ACS Catalysis

Stereodefined Access to Lactams via Olefin Difunctionalization: Iridium Nitrenoids as a Motif of LUMO-Controlled Dipoles

(2019) Seung Youn Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Copper-Catalyzed Multicomponent Synthesis of N-Acyl Amidines via Acyl Nitrenes

(2019) Kaj M. van Vliet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing Secondary Coordination Sphere Interactions That Enable the Selective Amidation of Benzylic C–H Bonds

(2019) Hoimin Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C–H Amidation

(2019) Hoi-Yun Jung et al.   ORGANIC LETTERS

Cobalt-Catalyzed Ortho-C(sp2)–H Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Groups

(2019) Jie Huang et al.   ORGANIC LETTERS

α-Branched amines by catalytic 1,1-addition of C–H bonds and aminating agents to terminal alkenes

(2019) Soham Maity et al.   Nature Catalysis

Non-C2-Symmetric Chiral-at-Ruthenium Catalyst for Highly Efficient Enantioselective Intramolecular C(sp3)–H Amidation

(2019) Zijun Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds

(2019) Yang Yang et al.   Nature Chemistry

CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes

(2018) Yujing Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective formation of γ-lactams via C–H amidation enabled by tailored iridium catalysts

(2018) Seung Youn Hong et al.   SCIENCE

Revisiting Arene C(sp2 )−H Amidation by Intramolecular Transfer of Iridium Nitrenoids: Evidence for a Spirocyclization Pathway

(2018) Yeongyu Hwang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ir(III)-Catalyzed Stereoselective Haloamidation of Alkynes Enabled by Ligand Participation

(2018) Seung Youn Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C(sp3 )-H Amidation of Thioamides Catalyzed by a CobaltIII /Chiral Carboxylic Acid Hybrid System

(2018) Seiya Fukagawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst-Controlled Nitrene Transfer by Tuning Metal:Ligand Ratios: Insight into the Mechanisms of Chemoselectivity

(2017) Cale Weatherly et al.   ORGANOMETALLICS

Mechanochemical Rhodium(III)-Catalyzed C–H Bond Amidation of Arenes with Dioxazolones under Solventless Conditions in a Ball Mill

(2017) Gary N. Hermann et al.   ACS Catalysis

Catalyst: Sustainable Catalysis

(2017) Jacob R. Ludwig et al.   Chem

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Control of the Chemoselectivity of Metal N-Aryl Nitrene Reactivity: C–H Bond Amination versus Electrocyclization

(2016) Chen Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Why is the Ir(III)-Mediated Amido Transfer Much Faster Than the Rh(III)-Mediated Reaction? A Combined Experimental and Computational Study

(2016) Yoonsu Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biologically active γ-lactams: synthesis and natural sources

(2016) J. Caruano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Curtius-like Rearrangement of an Iron–Nitrenoid Complex and Application in Biomimetic Synthesis of Bisindolylmethanes

(2016) Dashan Li et al.   ORGANIC LETTERS

Selective Rhodium-Catalyzed C–H Amidation of Azobenzenes with Dioxazolones under Mild Conditions

(2016) Bomi Jeon et al.   ORGANIC LETTERS

Quinazoline Synthesis via Rh(III)-Catalyzed Intermolecular C–H Functionalization of Benzimidates with Dioxazolones

(2016) Jie Wang et al.   ORGANIC LETTERS

Dirhodium-catalyzed C-H arene amination using hydroxylamines

(2016) M. P. Paudyal et al.   SCIENCE

Oxazolinyl-Assisted C–H Amidation by Cobalt(III) Catalysis

(2016) Ruhuai Mei et al.   ACS Catalysis

Transition-Metal-Catalyzed C–N Bond Forming Reactions Using Organic Azides as the Nitrogen Source: A Journey for the Mild and Versatile C–H Amination

(2015) Kwangmin Shin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Comparative Catalytic Activity of Group 9 [Cp*MIII] Complexes: Cobalt-Catalyzed CH Amidation of Arenes with Dioxazolones as Amidating Reagents

(2015) Juhyeon Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-Catalyzed Amidation of Unactivated C(sp3)H Bonds

(2015) He Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives

(2015) Yujie Liang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic Studies on the Rh(III)-Mediated Amido Transfer Process Leading to Robust C–H Amination with a New Type of Amidating Reagent

(2015) Yoonsu Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Study of Sustainability and Scalability in the Cp*Rh(III)-Catalyzed Direct C–H Amidation with 1,4,2-Dioxazol-5-ones

(2015) Yoonsu Park et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Light-Induced Ruthenium-Catalyzed Nitrene Transfer Reactions: A Photochemical Approach towards N-Acyl Sulfimides and Sulfoximines

(2014) Vincent Bizet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct CH Amination of Arenes with Alkyl Azides under Rhodium Catalysis

(2013) Kwangmin Shin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ir(III)-Catalyzed Mild C–H Amidation of Arenes and Alkenes: An Efficient Usage of Acyl Azides as the Nitrogen Source

(2013) Jaeyune Ryu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination

(2013) E. T. Hennessy et al.   SCIENCE

Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds

(2012) Jennifer L. Roizen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Rhodium-Catalyzed Direct CH Amination of Benzamides with Aryl Azides: A Synthetic Route to Diarylamines

(2012) Jaeyune Ryu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed Intermolecular Amidation of Arenes with Sulfonyl Azides via Chelation-Assisted C–H Bond Activation

(2012) Ji Young Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rh2(II)-Catalyzed Intramolecular Aliphatic C–H Bond Amination Reactions Using Aryl Azides as the N-Atom Source

(2012) Quyen Nguyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE

A mechanistic analysis of the Rh-catalyzed intramolecular C–H amination reaction

(2008) Kristin Williams Fiori et al.   TETRAHEDRON