期刊
ORGANIC LETTERS
卷 21, 期 17, 页码 7099-7103出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02673
关键词
-
资金
- Institute for Basic Science [IBS-R010-A2]
A new approach has elaborated on the conversion of gamma-lactones to the corresponding NH gamma-lactams that can serve as gamma-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH gamma-lactam building blocks starting from gamma-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.
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