Lithium and Therapeutic Targeting of GSK-3

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Targeting GSK3 and Associated Signaling Pathways Involved in Cancer

(2020) Przemysław Duda et al.   Cells

Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia

(2020) Masumi Ueda et al.   Frontiers in Oncology

Lithium’s antiviral effects: a potential drug for CoViD-19 disease?

(2020) Andrea Murru et al.   International Journal of Bipolar Disorders

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib

(2020) Junyu Li et al.   Frontiers in Molecular Neuroscience

Glycogen Synthase Kinase 3β in Cancer Biology and Treatment

(2020) Takahiro Domoto et al.   Cells

Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma

(2019) Colleen T. Harrington et al.   LEUKEMIA

Lithium treatment for unipolar major depressive disorder: Systematic review

(2019) Juan Undurraga et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

(2019) Xiaosheng Wu et al.   BLOOD

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

(2019) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma

(2019) Tomohiro Kitabayashi et al.   Scientific Reports

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Upregulated β-catenin signaling does not affect survival of pancreatic cancer cells during dual inhibition of GSK3B and HDAC

(2019) Kateryna Nesteruk et al.   PANCREATOLOGY

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

(2018) Ratan V. Bhat et al.   JOURNAL OF ALZHEIMERS DISEASE

Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro

(2018) Hong-jie Li et al.   RESEARCH IN VETERINARY SCIENCE

Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction

(2018) Firli R.P. Dewi et al.   Oncotarget

Antagonistic role of GSK3 isoforms in glioma survival

(2018) Vidhi Vashishtha et al.   Journal of Cancer

Characterisation of mesenchymal colon tumour-derived cells in tumourspheres as a model for colorectal cancer progression

(2018) Mimmo Turano et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction

(2018) Lei Ji et al.   MOLECULAR CELL

An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice

(2018) Mouad Edderkaoui et al.   GASTROENTEROLOGY

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors

(2018) Aslamuzzaman Kazi et al.   Nature Communications

Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing

(2017) Mansi Y. Shinde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro

(2017) Fu-Rong Zhao et al.   JOURNAL OF MEDICAL VIROLOGY

The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition

(2017) Ryo Ishida et al.   MOLECULAR CANCER RESEARCH

Stressed and Inflamed, Can GSK3 Be Blamed?

(2017) Richard S. Jope et al.   TRENDS IN BIOCHEMICAL SCIENCES

Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells

(2017) Dheeraj Bhavanasi et al.   Blood Cancer Journal

GSK-3β inhibitor, 9-ING-41, reduces cell viability and halts proliferation of B-cell lymphoma cell lines as a single agent and in combination with novel agents

(2017) Reem Karmali et al.   Oncotarget

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Diallyl Disulfide (DADS), a Constituent of Garlic, Inactivates NF- B and Prevents Colitis-Induced Colorectal Cancer by Inhibiting GSK-3 

(2016) S. M. Saud et al.   Cancer Prevention Research

Lithium, a Therapy for AD: Current Evidence from Clinical Trials of Neurodegenerative Disorders

(2016) Orestes V. Forlenza et al.   Current Alzheimer Research

An open-label phase 2 study of glycogen synthase kinase-3 inhibitor LY2090314 in patients with acute leukemia

(2016) David A. Rizzieri et al.   LEUKEMIA & LYMPHOMA

GSK-3  Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression

(2016) S. Baumgart et al.   MOLECULAR CANCER THERAPEUTICS

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22

(2016) Aidong Zhou et al.   NATURE CELL BIOLOGY

Repression of GSK3 restores NK cell cytotoxicity in AML patients

(2016) Reshmi Parameswaran et al.   Nature Communications

GSK-3β controls NF-kappaB activity via IKKγ/NEMO

(2016) Senad Medunjanin et al.   Scientific Reports

Inhibitory effects of LiCl on replication of type II porcine reproductive and respiratory syndrome virus in vitro

(2015) Jin Cui et al.   ANTIVIRAL THERAPY

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

(2015) Ye Chen et al.   ARCHIVES OF VIROLOGY

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

(2015) Yuki Yoshino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GSK3β and Gli3 play a role in activation of Hedgehog-Gli pathway in human colon cancer — Targeting GSK3β downregulates the signaling pathway and reduces cell proliferation

(2015) Diana Trnski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Subtyping Pancreatic Cancer

(2015) Andrew V. Biankin et al.   CANCER CELL

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

(2015) Lukas E. Dow et al.   CELL

Lithium chloride induces mesenchymal-to-epithelial reverting transition in primary colon cancer cell cultures

(2015) VALERIA COSTABILE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A first-in-human phase I dose-escalation, pharmacokinetic, and pharmacodynamic evaluation of intravenous LY2090314, a glycogen synthase kinase 3 inhibitor, administered in combination with pemetrexed and carboplatin

(2015) Jhanelle E. Gray et al.   INVESTIGATIONAL NEW DRUGS

Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β

(2015) Shengquan Hu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation

(2015) V Tosello et al.   LEUKEMIA

Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression

(2015) Selvi Kunnimalaiyaan et al.   HPB

Potential application of lithium in Parkinson's and other neurodegenerative diseases

(2015) Carol A. Lazzara et al.   Frontiers in Neuroscience

Critical role of NF-κB in pancreatic cancer

(2015) Lakshmi Prabhu et al.   Oncotarget

Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells

(2015) Yuki Yoshino et al.   Scientific Reports

Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients

(2014) Maria C. Puertas et al.   AIDS

Transcriptional Control of Early T and B Cell Developmental Choices

(2014) Ellen V. Rothenberg   Annual Review of Immunology

The SARS coronavirus nucleocapsid protein – Forms and functions

(2014) Chung-ke Chang et al.   ANTIVIRAL RESEARCH

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells

(2014) Christin Kretzschmar et al.   BMC CANCER

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription

(2014) Chia-Hsin Wu et al.   Cell Host & Microbe

Glycogen Synthase Kinase 3  Sustains Invasion of Glioblastoma via the Focal Adhesion Kinase, Rac1, and c-Jun N-Terminal Kinase-Mediated Pathway

(2014) Y. Chikano et al.   MOLECULAR CANCER THERAPEUTICS

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial

(2014) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

(2014) J-S Zhang et al.   Cell Death & Disease

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

(2014) E Beurel et al.   Translational Psychiatry

From guinea pigs to manic patients: Cade’s ‘story of lithium’

(2013) Johan Schioldann   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O 6 -methylguanine DNA methyltransferase promoter methylation via c-Myc signaling

(2013) Ilya V. Pyko et al.   CARCINOGENESIS

Inhibition of GSK3B Bypass Drug Resistance of p53-Null Colon Carcinomas by Enabling Necroptosis in Response to Chemotherapy

(2013) E. Grassilli et al.   CLINICAL CANCER RESEARCH

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

(2013) A. J. Valvezan et al.   Disease Models & Mechanisms

The Cellular Interactome of the Coronavirus Infectious Bronchitis Virus Nucleocapsid Protein and Functional Implications for Virus Biology

(2013) E. Emmott et al.   JOURNAL OF VIROLOGY

Polarized Regulation of Glycogen Synthase Kinase-3β Is Important for Glioma Cell Invasion

(2013) Qifei Zou et al.   PLoS One

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

Reversible Modification of Adenomatous Polyposis Coli (APC) with K63-linked Polyubiquitin Regulates the Assembly and Activity of the β-Catenin Destruction Complex

(2012) Hoanh Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

(2012) Jian Huang et al.   NATURE MEDICINE

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

(2012) Shadi Mamaghani et al.   PLoS One

GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

(2012) Alexander J. Valvezan et al.   Frontiers in Molecular Neuroscience

Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

(2011) S. P. Williams et al.   CANCER RESEARCH

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

(2011) Lina Tsaadon Alon et al.   FEBS LETTERS

Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib

(2011) Juan Manuel Domínguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenomatous Polyposis Coli (APC) Regulates Multiple Signaling Pathways by Enhancing Glycogen Synthase Kinase-3 (GSK-3) Activity

(2011) Alexander J. Valvezan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine

(2011) Takeo Shimasaki et al.   JOURNAL OF GASTROENTEROLOGY

Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway

(2011) Mohammad Reza Mirlashari et al.   LEUKEMIA RESEARCH

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

(2011) E Beurel et al.   MOLECULAR PSYCHIATRY

GSK-3α/β kinases and amyloid production in vivo

(2011) Tomasz Jaworski et al.   NATURE

Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson’s Disease

(2011) Yue Yong et al.   NEUROCHEMICAL RESEARCH

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer

(2011) J-S Zhang et al.   ONCOGENE

Action Mechanisms of Lithium Chloride on Cell Infection by Transmissible Gastroenteritis Coronavirus

(2011) Xiaofeng Ren et al.   PLoS One

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase

(2010) Y. Karakama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis

(2010) Zhong Wang et al.   CANCER CELL

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Glycogen synthase kinase−3β inhibitors suppress leukemia cell growth

(2010) Emma Y. Song et al.   EXPERIMENTAL HEMATOLOGY

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

(2010) Jonathan Wills et al.   EXPERIMENTAL NEUROLOGY

Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era

(2010) Noah S Philip et al.   EXPERT OPINION ON PHARMACOTHERAPY

Tau protein: Relevance to Parkinson's disease

(2010) Peng Lei et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

(2010) Esther A. Guzmán et al.   INVESTIGATIONAL NEW DRUGS

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

(2010) Raquel Gómez-Sintes et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

(2010) Preeti J Khandelwal et al.   Molecular Neurodegeneration

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

(2010) Sushma Gurumurthy et al.   NATURE

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

(2010) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

A New α5β1 Integrin-Dependent Survival Pathway Through GSK3β Activation in Leukemic Cells

(2010) Fabienne De Toni-Costes et al.   PLoS One

Inhibition of Glioblastoma Growth by the Thiadiazolidinone Compound TDZD-8

(2010) Diana Aguilar-Morante et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

A critical appraisal of lithium’s efficacy and effectiveness: the last 60 years

(2009) Paul Grof et al.   BIPOLAR DISORDERS

The history of lithium therapy

(2009) Edward Shorter   BIPOLAR DISORDERS

Potential Therapeutic Effect of Glycogen Synthase Kinase 3  Inhibition against Human Glioblastoma

(2009) K. Miyashita et al.   CLINICAL CANCER RESEARCH

Deregulated GSK3  Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase

(2009) W. Mai et al.   CLINICAL CANCER RESEARCH

α-Synuclein contributes to GSK-3β-catalyzed Tau phosphorylation in Parkinson’s disease models

(2009) Tetyana Duka et al.   FASEB JOURNAL

Glycogen synthase kinases-3β controls differentiation of malignant glioma cells

(2009) Yan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice

(2009) Jian Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells

(2009) Irina N. Gaisina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endogenous Aβ causes cell death via early tau hyperphosphorylation

(2009) G. Amadoro et al.   NEUROBIOLOGY OF AGING

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

(2009) Serdar Korur et al.   PLoS One

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 /  in Pancreatic Cancer

(2008) W. Wilson et al.   CANCER RESEARCH

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor- B, and Glucose Regulation

(2008) S. Kotliarova et al.   CANCER RESEARCH

A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior

(2008) Jean-Martin Beaulieu et al.   CELL

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

(2008) Wynne Peterson-Nedry et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization

(2008) Tsui-Yi Peng et al.   FEBS Journal

Glycogen Synthase Kinase-3 Regulates the Phosphorylation of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein and Viral Replication

(2008) Chia-Hsin Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3

(2008) Michal O. Nowicki et al.   NEURO-ONCOLOGY

Glycogen synthase kinase-3beta is associated with Parkinson's disease

(2008) Masahiro Nagao et al.   NEUROSCIENCE LETTERS

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

The SARS-CoV nucleocapsid protein: A protein with multifarious activities

(2007) Milan Surjit et al.   INFECTION GENETICS AND EVOLUTION