Article
Biochemistry & Molecular Biology
Qiaoni Shi, Kexin Kang, Ye-Guang Chen
Summary: The intracellular multiprotein complex beta-catenin destruction complex is essential for Wnt/beta-catenin signaling, with recent studies showing the importance of liquid-liquid phase separation (LLPS) of Axin and APC in regulating this pathway. Post-translational modifications also play a role in the regulation of Axin LLPS.
Article
Multidisciplinary Sciences
Line Mygland, Shoshy Alam Brinch, Martin Frank Strand, Petter Angell Olsen, Aleksandra Aizenshtadt, Kaja Lund, Nina Therese Solberg, Max Lycke, Tor Espen Thorvaldsen, Sandra Espada, Dorna Misaghian, Christian M. Page, Oleg Agafonov, Stale Nygard, Nai-Wen Chi, Eva Lin, Jenille Tan, Yihong Yu, Mike Costa, Stefan Krauss, Jo Waaler
Summary: Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors have shown to be effective antitumor agents in specific tumor cell lines, with the ability to inhibit key signaling pathways and reduce expression of crucial oncogenes, ultimately impairing cell growth. Additionally, these inhibitors induce the accumulation of beta-catenin degradasomes containing TNKS1/2, which interact with YAP and angiomotin proteins, leading to attenuation of YAP signaling. Further research is needed to fully evaluate the potential of TNKS inhibitors in cancer treatment.
Article
Oncology
Anja Kafka, Anja Bukovac, Emilija Brglez, Ana-Marija Jarmek, Karolina Poljak, Petar Brlek, Kamelija Zarkovic, Niko Njiric, Nives Pecina-Slaus
Summary: This study investigated genetic and epigenetic changes as well as protein expression levels of negative regulators of Wnt signaling in human astrocytomas. The results emphasize the importance of methylation in Wnt signaling regulation, and suggest that large deletions of the APC gene and effects of beta-catenin and GSK3 beta play key roles in astrocytoma evolution. Further studies are needed to understand the clinical and therapeutic relevance of these molecular alterations.
Review
Cell Biology
Chenchen Li, Emma E. Furth, Anil K. Rustgi, Peter S. Klein
Summary: The Wnt signaling pathway is crucial in metazoan development and stem cell maintenance, and is also involved in various malignancies. Apart from the canonical activation, the pathway can affect cell function through multiple alternative effectors, potentially contributing to cancer development.
Article
Biochemistry & Molecular Biology
Bi-juan Yang, Shi-rui Fan, Xin-fang Zhang, Jie-yun Cai, Ting Ruan, Zheng-rui Xiang, Juan Ren, Xiao-jiang Hao, Duo-zhi Chen
Summary: This study explores the potential of activating the Wnt/β-catenin signaling pathway for the treatment of vitiligo through the design and synthesis of compounds. The results suggest that compounds 41 and 43 may be potential candidates for vitiligo treatment.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kibrom M. Alula, Yaritza Delgado-Deida, Dakota N. Jackson, K. Venuprasad, Arianne L. Theiss
Summary: PHB1 plays a role in inhibiting the Wnt/β-catenin pathway to influence the development of intestinal tumorigenesis by regulating AXIN1 expression and the beta-catenin destruction complex. Induction of nuclear PHB1 trafficking provides a novel therapeutic option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestinal tumorigenesis.
Article
Oncology
Kathleen A. O'Leary, Debra E. Rugowski, Michael P. Shea, Ruth Sullivan, Amy R. Moser, Linda A. Schuler
Summary: Prolactin (PRL) collaborates with Apc(Min/+) to increase tumor incidence and modulate cancer stem cell activity through Notch-driven signals, shedding light on mechanisms whereby PRL elevates risk of breast cancer.
Article
Cell Biology
Kexin Kang, Qiaoni Shi, Xu Wang, Ye-Guang Chen
Summary: Kang et al. demonstrate that Dvl2 undergoes phase separation and rapidly accumulates to the plasma membrane upon Wnt stimulation. Dvl2 phase separation plays a crucial role in the assembly of the Wnt receptor signalosome and disruption of the beta-catenin destruction complex.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Oncology
Y. Taank, N. Agnihotri
Summary: Aberrant Wnt/beta-catenin signaling plays a central role in the carcinogenesis of colorectal cancer. While targeting this pathway holds potential for treatment, current approaches have not been successful in clinical practice, prompting the need for new strategies. Recent studies have identified beta-catenin regulators that show promise in modulating the pathway and influencing the development of CRC and other solid tumors. Further research on the detailed mechanisms of these regulators may lead to improved treatment approaches.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Summary: Targeting cancer hallmarks is crucial for improving anti-cancer treatment, but cross-talk between signaling pathways often leads to resistance. This article provides an overview of the molecular interactions between the p53 and Wnt pathways in cancer, including complex feedback loops and reciprocal transactivation, as well as the mutational landscape of genes associated with these pathways.
Article
Pathology
Sonja Chen, Sara Gallant, Michael J. Cunningham, Caroline D. Robson, Alanna J. Church, Antonio R. Perez-Atayde, Alyaa Al-Ibraheemi
Summary: This study describes 8 cases of sinonasal myxoma (SNM) and analyzes the clinical and biological differences compared to desmoid fibromatosis. The findings expand the understanding of SNM and highlight its differences from desmoid fibromatosis in histology, clinical characteristics, and genetics.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Cell Biology
Junxiu Nong, Kexin Kang, Qiaoni Shi, Xuechen Zhu, Qinghua Tao, Ye-Guang Chen
Summary: The liquid-liquid phase separation of Axin drives the formation of the destruction complex, facilitating the recruitment of other members and promoting phosphorylation of beta-catenin, critical for regulating Wnt/beta-catenin signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Romain Sanson, Silvia Luna Lazzara, David Cune, Caterina Luana Pitasi, Coralie Trentesaux, Marie Fraudeau, Franck Letourneur, Benjamin Gaintpierre, Morgane Le Gall, Pascale Bossard, Benoit Terris, Pascal Finetti, Francois Bertucci, Emilie Mamessier, Beatrice Romagnolo, Christine Perret
Summary: Axin1 is a negative regulator of the Wnt/beta-catenin signaling pathway with tumor-suppressor function. It has redundant function with Axin2 for down-regulation of the pathway in normal intestine. Axin1 deficiency increases susceptibility to chemically induced colon carcinogenesis, but reduces dextran sulfate sodium-induced colitis by attenuating the induction of a proinflammatory program. Axin1 controls an interferon gamma/Th1 immune program that enhances the inflammatory response and prevents tumor growth. The Axin1-dependent gene expression signature identifies a group of patients with potential vulnerability to immune checkpoint blockade therapies in colorectal cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jilly Frances Evans, Kseniya Obraztsova, Susan M. Lin, Vera P. Krymskaya
Summary: The study focuses on the mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks and their impact on cancer, drug resistance, and stem cell exhaustion, as well as the lung disease lymphangioleiomyomatosis (LAM). The review highlights potential therapeutic approaches targeting these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Aysenur Gok, Aynur Isik, Sinem Bakir, Sarp Uzun, Gunes Guner, Ozge Ozcan, Baris Cerci, Ilyas Onbasilar, Aytekin Akyol
Summary: This study examined the effects of reduced Bdnf levels in an Apc mutant intestinal/colonic tumor mouse model. The results showed that Bdnf mutant and Apc/Bdnf double mutant mice had a significant weight gain compared to controls. The small intestine polyp count decreased slightly in Apc/Bdnf double mutant mice, while the colon polyp count increased significantly.
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)