Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease

Targeting selective autophagy by AUTAC degraders

(2020) Daiki Takahashi et al.   Autophagy

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

(2020) Ziying Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease

(2020) Lucia Barazzuol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LRRK2 in Parkinson disease: challenges of clinical trials

(2020) Eduardo Tolosa et al.   Nature Reviews Neurology

Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations

(2020) Stephen Mullin et al.   JAMA Neurology

Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons

(2020) Matthew E Gegg et al.   HUMAN MOLECULAR GENETICS

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

(2020) Marco A. S. Baptista et al.   Science Translational Medicine

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease

(2020) Giulia Lamonaca et al.   Cells

Activation of AMPK/aPKCζ/CREB pathway by metformin is associated with upregulation of GDNF and dopamine

(2020) Nikita Katila et al.   BIOCHEMICAL PHARMACOLOGY

LRRK2 kinase inhibitors reduce alpha-synuclein in human neuronal cell lines with the G2019S mutation

(2020) Ye Zhao et al.   NEUROBIOLOGY OF DISEASE

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

(2020) Darren M. O’Hara et al.   Frontiers in Neuroscience

Therapeutic strategies for Parkinson’s disease: promising agents in early clinical development

(2020) Margherita Fabbri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

α-Synuclein Overexpression Induces Lysosomal Dysfunction and Autophagy Impairment in Human Neuroblastoma SH-SY5Y

(2020) Ana Carolina Nascimento et al.   NEUROCHEMICAL RESEARCH

LRRK2 and the Endolysosomal System in Parkinson’s Disease

(2020) Madalynn L. Erb et al.   Journal of Parkinsons Disease

LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson’s disease

(2019) Fiona Bonello et al.   HUMAN MOLECULAR GENETICS

Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration

(2019) Alan J. Fowler et al.   Drugs in research & development

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

(2019) Zhou Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

(2019) Philip Wing-Lok Ho et al.   Autophagy

LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

(2019) Fieke Wauters et al.   Autophagy

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

(2019) Jiahong Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multiple molecular pathways stimulating macroautophagy protect from alpha-synuclein-induced toxicity in human neurons

(2019) Matthias Höllerhage et al.   NEUROPHARMACOLOGY

The effect of resveratrol on neurodegenerative disorders: possible protective actions against autophagy, apoptosis, inflammation and oxidative stress

(2019) Mohammad Hossein Pourhanifeh et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective Effects of the Small-Molecule Enhancer of Rapamycin in the Cellular Model of Parkinson’s Disease

(2019) S. Darabi et al.   NEUROPHYSIOLOGY

ATTEC: a potential new approach to target proteinopathies

(2019) Zhaoyang Li et al.   Autophagy

Autophagy activation promotes clearance of α-synuclein inclusions in fibril-seeded human neural cells

(2019) Jianqun Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leucine‐rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease

(2019) Susanna Cogo et al.   JOURNAL OF NEUROCHEMISTRY

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

The crosstalk between autophagy and apoptosis was mediated by phosphorylation of Bcl-2 and beclin1 in benzene-induced hematotoxicity

(2019) Yujiao Chen et al.   Cell Death & Disease

Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior

(2019) Benjamin H.M. Hunn et al.   Cell Reports

Neuroprotective effects of curcumin through autophagy modulation

(2019) Fatemeh Forouzanfar et al.   IUBMB LIFE

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk

(2019) Yam Nath Paudel et al.   PHARMACOLOGICAL RESEARCH

Autophagy and LRRK2 in the Aging Brain

(2019) Federica Albanese et al.   Frontiers in Neuroscience

Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration

(2019) Suresh SN et al.   EBioMedicine

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy

(2018) Federico Rossari et al.   Journal of Hematology & Oncology

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment

(2018) Liang Ouyang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction

(2018) Yixian Ren et al.   TOXICOLOGICAL SCIENCES

PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats

(2018) Michael Aagaard Andersen et al.   TOXICOLOGY

LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats

(2018) Qin Rui et al.   Frontiers in Cellular Neuroscience

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

(2018) Shigeto Sato et al.   Scientific Reports

Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

(2018) Daniel W. Curry et al.   Journal of Parkinsons Disease

Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective

(2018) S. N. Suresh et al.   Frontiers in Molecular Neuroscience

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

(2018) Yanan Luan et al.   Frontiers in Neuroscience

Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations

(2018) Hongyu Li et al.   Autophagy

Mechanistic/mammalian target of rapamycin: Recent pathological aspects and inhibitors

(2018) Mohammed S. Abdel-Maksoud et al.   MEDICINAL RESEARCH REVIEWS

Glycyrrhizic Acid Alleviates 6-Hydroxydopamine and Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells Through Modulating Autophagy

(2018) Guangyi Yang et al.   NEUROCHEMICAL RESEARCH

The nuclear receptor superfamily: A structural perspective

(2018) Emily R. Weikum et al.   PROTEIN SCIENCE

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

LRRK2 impairs autophagy by mediating phosphorylation of leucyl-tRNA synthetase

(2018) Dong Hwan Ho et al.   CELL BIOCHEMISTRY AND FUNCTION

Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation

(2018) Sandra M. Hill et al.   CELL DEATH AND DIFFERENTIATION

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

(2018) Ruoxi Wang et al.   JOURNAL OF CELL BIOLOGY

Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

(2018) Michaela E. Johnson et al.   TRENDS IN NEUROSCIENCES

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

(2018) Silvia Bolognin et al.   Advanced Science

Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells

(2018) Dongying Yan et al.   FOOD AND CHEMICAL TOXICOLOGY

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

(2017) Andrew B. West   EXPERIMENTAL NEUROLOGY

Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease

(2017) Zhan-ying Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

(2017) Yi-Da Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

(2017) Jack D. Scott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

(2017) Xu Qian et al.   MOLECULAR CELL

Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson’s Disease

(2017) Rosalba Siracusa et al.   MOLECULAR NEUROBIOLOGY

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

(2017) Wojciech Bobela et al.   Molecular Neurodegeneration

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson’s disease

(2017) Seo Young Kang et al.   NEUROSCIENCE LETTERS

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

(2017) Francesco Longo et al.   Acta Neuropathologica Communications

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission

(2016) Qi Qin et al.   CNS Neuroscience & Therapeutics

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

(2016) Pilar Rivero-Ríos et al.   Current Neuropharmacology

Development of highly potent phosphodiesterase 4 inhibitors with anti-neuroinflammation potential: Design, synthesis, and structure-activity relationship study of catecholamides bearing aromatic rings

(2016) Zhong-Zhen Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

(2016) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Therapeutic approaches in Parkinson's disease and related disorders

(2016) Elvira Valera et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance

(2016) Judith Blanz et al.   JOURNAL OF NEUROCHEMISTRY

A New Glucocerebrosidase Chaperone Reduces  -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

(2016) E. Aflaki et al.   JOURNAL OF NEUROSCIENCE

Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3

(2016) Yan-Jie Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals

(2016) Sandra-Fausia Soukup et al.   NEURON

Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

(2016) Beth Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

(2016) Carla F. Bento et al.   Nature Communications

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

(2016) Alvaro Sanchez-Martinez et al.   Scientific Reports

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

(2016) Claudia Manzoni et al.   Scientific Reports

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

(2015) Mari H. Savolainen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Resveratrol Protects from Toxin-Induced Parkinsonism: Plethora of Proofs Hitherto Petty Translational Value

(2015) Mohd Sami ur Rasheed et al.   MOLECULAR NEUROBIOLOGY

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

(2015) Giulia Ambrosi et al.   NEUROBIOLOGY OF DISEASE

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

Co-activation of AMPK and mTORC1 Induces Cytotoxicity in Acute Myeloid Leukemia

(2015) Pierre Sujobert et al.   Cell Reports

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

(2014) Alisdair McNeill et al.   BRAIN

c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease

(2014) Anne-Laure Mahul-Mellier et al.   HUMAN MOLECULAR GENETICS

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

(2014) Jaclyn L. Henderson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

(2014) Mari H. Savolainen et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice

(2014) S.P. Patil et al.   NEUROSCIENCE

A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy

(2014) Franziska Richter et al.   Neurotherapeutics

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling

(2014) S Saez-Atienzar et al.   Cell Death & Disease

The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

(2014) Senthilkumar S. Karuppagounder et al.   Scientific Reports

CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease

(2014) Richard L. Jayaraj et al.   Biomed Research International

HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression

(2013) Ju-Xian Song et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

The association between Parkinson's disease and anti-epilepsy drug carbamazepine: a case-control study using the UK General Practice Research Database

(2013) Áine Skow et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

(2013) Anthony A. Estrada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Discovery of Pyridones As Oral AMPK Direct Activators

(2013) Olivier Mirguet et al.   ACS Medicinal Chemistry Letters

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

(2012) Jinwei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

(2012) Iakov N Rudenko et al.   BMC Medicine

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Novel NMDA receptor modulators: an update

(2012) Rose M Santangelo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling

(2012) Huifen Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Olfactory dysfunction in Parkinson disease

(2012) Richard L. Doty   Nature Reviews Neurology

mTOR: on target for novel therapeutic strategies in the nervous system

(2012) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE

Brain Penetrant LRRK2 Inhibitor

(2012) Hwan Geun Choi et al.   ACS Medicinal Chemistry Letters

Adenosine A2A Receptor Antagonists and Parkinson’s Disease

(2011) Brian C. Shook et al.   ACS Chemical Neuroscience

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

(2011) Andrew Ferree et al.   Neurodegenerative Diseases

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

(2010) Karen Nuytemans et al.   HUMAN MUTATION

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The estrogen-related receptor alpha: the oldest, yet an energetic orphan with robust biological functions

(2010) Harmit S. Ranhotra   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin

(2009) Guang Liang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Abl Kinases Regulate Autophagy by Promoting the Trafficking and Function of Lysosomal Components

(2008) Gouri Yogalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY