TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism
出版年份 2021 全文链接
标题
TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism
作者
关键词
-
出版物
Journal for ImmunoTherapy of Cancer
Volume 9, Issue 2, Pages e001798
出版商
BMJ
发表日期
2021-02-26
DOI
10.1136/jitc-2020-001798
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
- (2020) Constance J. Martin et al. Science Translational Medicine
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System
- (2018) Yan Qin et al. CELL
- Contextual determinants of TGFβ action in development, immunity and cancer
- (2018) Charles J. David et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
- (2018) Rikke B. Holmgaard et al. Journal for ImmunoTherapy of Cancer
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
- (2018) Anushka Dongre et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
- (2018) Stéphanie Liénart et al. SCIENCE
- Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses
- (2017) Joanne E. Konkel et al. IMMUNITY
- Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes
- (2017) Jingjing Zhu et al. Nature Communications
- Blockade of only TGF-β 1 and 2 is sufficient to enhance the efficacy of vaccine and PD-1 checkpoint blockade immunotherapy
- (2017) Masaki Terabe et al. OncoImmunology
- Dichotomous roles of TGF-β in human cancer
- (2016) Jennifer J. Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- TGF 1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
- (2016) B. V. Park et al. Cancer Discovery
- Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)
- (2015) Mario E. Lacouture et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
- (2015) Aida M. Bertoli-Avella et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma
- (2014) Qing-Min Fan et al. CANCER LETTERS
- TGF-β1 in Tumor Microenvironments Induces Immunosuppression in the Tumors and Sentinel Lymph Nodes and Promotes Tumor Progression
- (2014) Shoko Nakamura et al. JOURNAL OF IMMUNOTHERAPY
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Melanoma Cells Revive an Embryonic Transcriptional Network to Dictate Phenotypic Heterogeneity
- (2014) Niels Vandamme et al. Frontiers in Oncology
- Thoracic aortic-aneurysm and dissection in association with significant mitral valve disease caused by mutations in TGFB2
- (2012) Marjolijn Renard et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
- (2012) Mark E Lindsay et al. NATURE GENETICS
- TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome
- (2012) Catherine Boileau et al. NATURE GENETICS
- Targeting the TGFβ signalling pathway in disease
- (2012) Rosemary J. Akhurst et al. NATURE REVIEWS DRUG DISCOVERY
- Epithelial-Mesenchymal-Transition-Like and TGFβ Pathways Associated with Autochthonous Inflammatory Melanoma Development in Mice
- (2012) Maria Wehbe et al. PLoS One
- Gene silencing of TGF-β1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells
- (2011) Helen Conroy et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Role of TGF-β in Melanoma
- (2011) A. Busse et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Minimal Tolerance to a Tumor Antigen Encoded by a Cancer-Germline Gene
- (2011) I. J. Huijbers et al. JOURNAL OF IMMUNOLOGY
- Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection
- (2011) Catherine Uyttenhove et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Latent TGF-β structure and activation
- (2011) Minlong Shi et al. NATURE
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Tumor-Initiated Inflammation Overrides Protective Adaptive Immunity in an Induced Melanoma Model in Mice
- (2010) Saïdi M. Soudja et al. CANCER RESEARCH
- TGFβ in Cancer
- (2008) Joan Massagué CELL
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