Key Components of Inflammasome and Pyroptosis Pathways Are Deficient in Canines and Felines, Possibly Affecting Their Response to SARS-CoV-2 Infection

A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

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Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

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SARS-CoV-2 spike protein favors ACE2 from Bovidae and Cricetidae

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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Infection of dogs with SARS-CoV-2

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

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Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?

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Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection

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Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins

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Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

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Inflammasome Activation and Pyroptosis in Lymphopenic COVID-19 Liver Patients

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Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

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First detection and genome sequencing of SARS‐CoV‐2 in an infected cat in France

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ACE2 isoform diversity predicts the host susceptibility of SARS‐CoV‐2

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Severe COVID-19: NLRP3 Inflammasome Dysregulated

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Targeting the NLRP3 Inflammasome in Severe COVID-19

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First Reported Cases of SARS-CoV-2 Infection in Companion Animals — New York, March–April 2020

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Cytokine storm induced by SARS-CoV-2

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Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

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Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host

(2019) Matae Ahn et al.   Nature Microbiology

Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome

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Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

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CDD/SPARCLE: the conserved domain database in 2020

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Dampened STING-Dependent Interferon Activation in Bats

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Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome

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MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms

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SWISS-MODEL: homology modelling of protein structures and complexes

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Innate Sensing of DNA Virus Genomes

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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

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Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

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The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Unique Loss of the PYHIN Gene Family in Bats Amongst Mammals: Implications for Inflammasome Sensing

(2016) Matae Ahn et al.   Scientific Reports

DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment

(2015) Erik S. Wright   BMC BIOINFORMATICS

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

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Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

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The mammalian PYHIN gene family: Phylogeny, evolution and expression

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Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

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Duplication of the caspase-12 prodomain and inactivation of NLRC4/IPAF in the dog

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