Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
出版年份 2021 全文链接
标题
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
作者
关键词
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出版物
Advanced Science
Volume -, Issue -, Pages 2003937
出版商
Wiley
发表日期
2021-03-08
DOI
10.1002/advs.202003937
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood–Brain Barrier Model
- (2020) Diána Hudecz et al. ACS Nano
- Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy
- (2020) Jingyi Zhu et al. ACS Nano
- Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors
- (2020) Hao Wu et al. ADVANCED MATERIALS
- Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier
- (2020) Hyun Su Min et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases
- (2020) Priya Kumthekar et al. CLINICAL CANCER RESEARCH
- Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
- (2020) Song Ih Ahn et al. Nature Communications
- Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature
- (2020) Sharon Wei Ling Lee et al. Advanced Healthcare Materials
- PLGA-PEG-ANG-2 Nanoparticles for Blood–Brain Barrier Crossing: Proof-of-Concept Study
- (2020) Gina P. Hoyos-Ceballos et al. Pharmaceutics
- A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice
- (2020) Qian Guo et al. JOURNAL OF CONTROLLED RELEASE
- Materials for blood brain barrier modeling in vitro
- (2020) Magali P. Ferro et al. MATERIALS SCIENCE & ENGINEERING R-REPORTS
- Sulfoxide‐Containing Polymer‐Coated Nanoparticles Demonstrate Minimal Protein Fouling and Improved Blood Circulation
- (2020) Ruirui Qiao et al. Advanced Science
- Ultrabright Fluorescent Polymeric Nanoparticles with a Stealth Pluronic Shell for Live Tracking in the Mouse Brain
- (2020) Igor Khalin et al. ACS Nano
- Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells
- (2020) Elena Naumovska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dendrimer mediated targeted delivery of sinomenine for the treatment of acute neuroinflammation in traumatic brain injury
- (2020) Rishi Sharma et al. JOURNAL OF CONTROLLED RELEASE
- Key for crossing the BBB with nanoparticles: the rational design
- (2020) Sonia M Lombardo et al. Beilstein Journal of Nanotechnology
- Nano-curcumin simultaneously protects the blood-brain barrier and reduces M1-microglial activation during cerebral ischemia-reperfusion injury
- (2019) Ye Wang et al. ACS Applied Materials & Interfaces
- Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2019) Valery L Feigin et al. LANCET NEUROLOGY
- A journey through the emergence of nanomedicines with poly(alkylcyanoacrylate) based nanoparticles
- (2019) Christine Vauthier JOURNAL OF DRUG TARGETING
- Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo
- (2019) Kasper Bendix Johnsen et al. JOURNAL OF CONTROLLED RELEASE
- A window into the brain: Tools to assess preclinical efficacy of biomaterials-based therapies on central nervous system disorders
- (2019) Juhi Samal et al. ADVANCED DRUG DELIVERY REVIEWS
- Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery
- (2019) Alexander B. Cook et al. ADVANCED FUNCTIONAL MATERIALS
- Chitosan and chitosan coating nanoparticles for the treatment of brain disease
- (2019) Shuangwen Yu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages
- (2019) Tian Zhang et al. Advanced Healthcare Materials
- Gene Therapy Tools for Brain Diseases
- (2019) Selene Ingusci et al. Frontiers in Pharmacology
- Systematic Evaluation of Transferrin-Modified Porous Silicon Nanoparticles for Targeted Delivery of Doxorubicin to Glioblastoma
- (2019) Meihua Luo et al. ACS Applied Materials & Interfaces
- Design and Biological Evaluation of Lipoprotein-Based Donepezil Nanocarrier for Enhanced Brain Uptake through Oral Delivery
- (2019) Kowthavarapu Venkata Krishna et al. ACS Chemical Neuroscience
- Surface-Modified G4 PAMAM Dendrimers Cross the Blood–Brain Barrier Following Multiple Tail-Vein Injections in C57BL/6J Mice
- (2019) Bhairavi Srinageshwar et al. ACS Chemical Neuroscience
- Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions
- (2019) A. Da Silva-Candal et al. JOURNAL OF CONTROLLED RELEASE
- Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles
- (2019) Flávia Sousa et al. JOURNAL OF CONTROLLED RELEASE
- A Reconfigurable In Vitro Model for Studying the Blood–Brain Barrier
- (2019) Monica L. Moya et al. ANNALS OF BIOMEDICAL ENGINEERING
- Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System
- (2019) Delaney G. Fisher et al. Frontiers in Pharmacology
- Dendrimer-Based Drug Delivery Systems for Brain Targeting
- (2019) Yuefei Zhu et al. Biomolecules
- Poly(2-oxazoline) macromonomers as building blocks for functional and biocompatible polymer architectures
- (2019) David Pizzi et al. EUROPEAN POLYMER JOURNAL
- In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
- (2019) Jin-Ha Choi et al. Micromachines
- Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood–Brain Barrier System
- (2018) Dianjun Qi et al. ACS Applied Materials & Interfaces
- Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer
- (2018) Chunsheng He et al. ADVANCED FUNCTIONAL MATERIALS
- 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes
- (2018) Marco Campisi et al. BIOMATERIALS
- Block Copolymer Micelles in Nanomedicine Applications
- (2018) Horacio Cabral et al. CHEMICAL REVIEWS
- Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach
- (2018) Mark McCully et al. CURRENT PHARMACEUTICAL DESIGN
- Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration
- (2018) Marjolein Heymans et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Selective drug delivery approaches to lesioned brain through blood brain barrier disruption
- (2018) Zahraa S. Al-Ahmady Expert Opinion on Drug Delivery
- Bridging barriers: a comparative look at the blood–brain barrier across organisms
- (2018) Natasha M. O'Brown et al. GENES & DEVELOPMENT
- Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery
- (2018) Ines Beekers et al. IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
- Inflammation in CNS neurodegenerative diseases
- (2018) Jodie Stephenson et al. IMMUNOLOGY
- PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization
- (2018) Daniela E. Igartúa et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Effect of mannose targeting of hydroxyl PAMAM dendrimers on cellular and organ biodistribution in a neonatal brain injury model
- (2018) Anjali Sharma et al. JOURNAL OF CONTROLLED RELEASE
- Crossing the blood-brain barrier with nanoparticles
- (2018) Yiqun Zhou et al. JOURNAL OF CONTROLLED RELEASE
- Use of porous membranes in tissue barrier and co-culture models
- (2018) Henry H. Chung et al. LAB ON A CHIP
- Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium
- (2018) Andrea Falanga et al. MOLECULES
- Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model
- (2018) Dario Carradori et al. Nanomedicine-Nanotechnology Biology and Medicine
- A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease
- (2018) Joseph Park et al. NATURE NEUROSCIENCE
- Biodegradable Polymeric Nanoparticles for Therapeutic Cancer Treatments
- (2018) Johan Karlsson et al. Annual Review of Chemical and Biomolecular Engineering
- Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
- (2018) Christina Ising et al. Cell Death & Disease
- Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles
- (2018) Fred C. Lam et al. Nature Communications
- Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
- (2018) Kasper Bendix Johnsen et al. Theranostics
- Biomedical Applications of Chitosan and Its Derivative Nanoparticles
- (2018) Dongying Zhao et al. Polymers
- Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates
- (2018) Pierpaolo Moscariello et al. Advanced Science
- Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
- (2018) Quanguo He et al. Cells
- In Vivo Use of a Multi-DNA Aptamer-Based Payload/Targeting System To Study Dopamine Dysregulation in the Central Nervous System
- (2018) Erin M. McConnell et al. ACS Chemical Neuroscience
- Quantification of kinetic rate constants for transcytosis of polymeric nanoparticle through blood-brain barrier
- (2018) Aminul Islam Khan et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- In Silico Prediction of Blood-Brain Barrier Permeability of Compounds by Machine Learning and Resampling Methods
- (2018) Zhuang Wang et al. ChemMedChem
- A filter-free blood-brain barrier model to quantitatively study transendothelial delivery of nanoparticles by fluorescence spectroscopy
- (2018) Edwin De Jong et al. JOURNAL OF CONTROLLED RELEASE
- A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
- (2018) Ben M Maoz et al. NATURE BIOTECHNOLOGY
- Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier
- (2018) Iason Papademetriou et al. PLoS One
- Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
- (2018) Cristina Díaz-Perlas et al. Chemical Science
- Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma
- (2018) Yu Jiang et al. ACS Nano
- The potential for remodelling the tumour vasculature in glioblastoma
- (2018) Caterina Brighi et al. ADVANCED DRUG DELIVERY REVIEWS
- Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics
- (2018) Andras Polyak et al. CURRENT MEDICINAL CHEMISTRY
- A novel RGDyC/PEG co-modified PAMAM dendrimer-loaded arsenic trioxide of glioma targeting delivery system
- (2018) Yanping Lu et al. International Journal of Nanomedicine
- Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial
- (2018) Torayuki Okuyama et al. MOLECULAR THERAPY
- Length of surface PEG modulates nanocarrier transcytosis across brain vascular endothelial cells
- (2018) Soudeh F. Tehrani et al. Nanomedicine-Nanotechnology Biology and Medicine
- PLGA-Based Nanoparticles in Cancer Treatment
- (2018) Sima Rezvantalab et al. Frontiers in Pharmacology
- Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons
- (2018) Tatsuya Osaki et al. Science Advances
- Transferrin-conjugated magnetic dextran-spermine nanoparticles for targeted drug transport across blood-brain barrier
- (2017) Maryam Ghadiri et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application
- (2017) Philip Grossen et al. JOURNAL OF CONTROLLED RELEASE
- Development of PEGylated carboxylic acid-modified polyamidoamine dendrimers as bone-targeting carriers for the treatment of bone diseases
- (2017) Shugo Yamashita et al. JOURNAL OF CONTROLLED RELEASE
- A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier
- (2017) Giulia Adriani et al. LAB ON A CHIP
- Facile development of nanocomplex-in-nanoparticles for enhanced loading and selective delivery of doxorubicin to brain
- (2017) Amr Hefnawy et al. Nanomedicine
- HMDB 4.0: the human metabolome database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
- (2017) Attilio Marino et al. Small
- Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain
- (2017) Y. Anraku et al. Nature Communications
- Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment
- (2017) Cem Varan et al. Beilstein Journal of Nanotechnology
- PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer’s disease mice
- (2017) Na Huang et al. Oncotarget
- In Vitro Microfluidic Models for Neurodegenerative Disorders
- (2017) Tatsuya Osaki et al. Advanced Healthcare Materials
- A small variation in average particle size of PLGA nanoparticles prepared by nanoprecipitation leads to considerable change in nanoparticles’ characteristics and efficacy of intracellular delivery
- (2017) Adem Sahin et al. Artificial Cells Nanomedicine and Biotechnology
- A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes
- (2017) Seokyoung Bang et al. Scientific Reports
- Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization
- (2016) Melissa Santi et al. BIOCONJUGATE CHEMISTRY
- Nanoscale effects in dendrimer-mediated targeting of neuroinflammation
- (2016) Elizabeth Nance et al. BIOMATERIALS
- Shuttle-mediated nanoparticle transport across an in vitro brain endothelium under flow conditions
- (2016) Andrea P. Falanga et al. BIOTECHNOLOGY AND BIOENGINEERING
- Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening
- (2016) Ying I. Wang et al. BIOTECHNOLOGY AND BIOENGINEERING
- Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery
- (2016) Benjamí Oller-Salvia et al. CHEMICAL SOCIETY REVIEWS
- Into rather unexplored terrain-transcellular transport across the blood-brain barrier
- (2016) Marijke De Bock et al. GLIA
- Di-Block PLCL and Tri-Block PLCLG Matrix Polymeric Nanoparticles Enhanced the Anticancer Activity of Loaded 5-Fluorouracil
- (2016) Abdelkader E. Ashour et al. IEEE TRANSACTIONS ON NANOBIOSCIENCE
- Novel functionalization strategies of polymeric nanoparticles as carriers for brain medications
- (2016) Corinne Portioli et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
- (2016) Hans C Helms et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo
- (2016) Houmam Kafa et al. JOURNAL OF CONTROLLED RELEASE
- Effect of PLGA NP size on efficiency to target traumatic brain injury
- (2016) Luis J. Cruz et al. JOURNAL OF CONTROLLED RELEASE
- Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery
- (2016) Christoph Englert et al. JOURNAL OF CONTROLLED RELEASE
- A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment
- (2016) Yatao Yin et al. Materials Science & Engineering C-Materials for Biological Applications
- Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier
- (2016) Jack D. Wang et al. MOLECULAR PHARMACEUTICS
- Glioma-targeted superparamagnetic iron oxide nanoparticles as drug-carrying vehicles for theranostic effects
- (2016) He-Lin Xu et al. Nanoscale
- Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers
- (2016) Susanne Schöttler et al. Nature Nanotechnology
- Nanoparticles and radiotracers: advances toward radionanomedicine
- (2016) Edwin C. Pratt et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications
- (2016) Sheng Wang et al. Theranostics
- Strategies for transporting nanoparticles across the blood–brain barrier
- (2016) Tian-Tian Zhang et al. Biomaterials Science
- Nose to Brain Delivery of Midazolam Loaded PLGA Nanoparticles: In Vitro and In Vivo Investigations
- (2016) Deepak Sharma et al. Current Drug Delivery
- Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
- (2016) Einar Sulheim et al. JOURNAL OF NANOBIOTECHNOLOGY
- Brain-targeted delivery of resveratrol using solid lipid nanoparticles functionalized with apolipoprotein E
- (2016) Ana Rute Neves et al. JOURNAL OF NANOBIOTECHNOLOGY
- Analysis of nanoparticle delivery to tumours
- (2016) Stefan Wilhelm et al. Nature Reviews Materials
- Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip
- (2016) Anna Herland et al. PLoS One
- A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors
- (2016) Hui Xu et al. Scientific Reports
- High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform
- (2016) Nienke R. Wevers et al. Scientific Reports
- Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA
- (2015) Corey J. Bishop et al. Acta Biomaterialia
- Collagen-based brain microvasculature model in vitro using three-dimensional printed template
- (2015) Jeong Ah Kim et al. Biomicrofluidics
- Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
- (2015) Jacquelyn A. Brown et al. Biomicrofluidics
- Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
- (2015) Yulin Li et al. CHEMICAL REVIEWS
- The dendrimer paradox – high medical expectations but poor clinical translation
- (2015) Sonke Svenson CHEMICAL SOCIETY REVIEWS
- Poly (ɛ-caprolactone) nanoparticles of carboplatin: Preparation, characterization and in vitro cytotoxicity evaluation in U-87 MG cell lines
- (2015) Vamshikrishna Karanam et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
- (2015) Rik van der Kant et al. DEVELOPMENTAL CELL
- Control of polymeric nanoparticle size to improve therapeutic delivery
- (2015) John W. Hickey et al. JOURNAL OF CONTROLLED RELEASE
- PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier
- (2015) C. Fornaguera et al. JOURNAL OF CONTROLLED RELEASE
- Systemic delivery of blood–brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue
- (2015) Jennifer K. Saucier-Sawyer et al. JOURNAL OF DRUG TARGETING
- In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches
- (2015) Anette Wolff et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture
- (2015) Edinson Lucumi Moreno et al. LAB ON A CHIP
- Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease
- (2015) JiSoo Park et al. LAB ON A CHIP
- Exploiting Bacterial Pathways for BBB Crossing with PLGA Nanoparticles Modified with a Mutated Form of Diphtheria Toxin (CRM197): In Vivo Experiments
- (2015) G. Tosi et al. MOLECULAR PHARMACEUTICS
- A Highlight of Recent Advances in Aptamer Technology and Its Application
- (2015) Hongguang Sun et al. MOLECULES
- PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting
- (2015) Yuliana Monsalve et al. Nanomedicine
- Impact of pegylation on biopharmaceutical properties of dendrimers
- (2015) Shrikant Thakur et al. POLYMER
- Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core
- (2015) Andrew J. Clark et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anatomy and physiology of the blood–brain barrier
- (2015) Yonatan Serlin et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- LRP-1-mediated intracellular antibody delivery to the Central Nervous System
- (2015) Xiaohe Tian et al. Scientific Reports
- Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology
- (2015) Hansang Cho et al. Scientific Reports
- Nanoparticle-Mediated Target Delivery of TRAIL as Gene Therapy for Glioblastoma
- (2015) Kui Wang et al. Advanced Healthcare Materials
- Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats
- (2015) Zhong-Yue Yuan et al. PLoS One
- A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip
- (2015) Sudhir P. Deosarkar et al. PLoS One
- Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy
- (2015) Brian C. Baumann et al. Oncotarget
- Brain-Targeted Delivery of Docetaxel by Glutathione-Coated Nanoparticles for Brain Cancer
- (2014) Aditya Grover et al. AAPS PHARMSCITECH
- Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution
- (2014) Kvar C. L. Black et al. ACS Nano
- Preparation methods of alginate nanoparticles
- (2014) Jerome P. Paques et al. ADVANCES IN COLLOID AND INTERFACE SCIENCE
- Radiolabeling of Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles with Biotinylated F-18 Prosthetic Groups and Imaging of Their Delivery to the Brain with Positron Emission Tomography
- (2014) Rachael W. Sirianni et al. BIOCONJUGATE CHEMISTRY
- Surface modified PLGA nanoparticles for brain targeting of Bacoside-A
- (2014) S. Jose et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Surfactants, not size or zeta-potential influence blood–brain barrier passage of polymeric nanoparticles
- (2014) Nadine Voigt et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- The importance of nanoparticle shape in cancer drug delivery
- (2014) Nghia P Truong et al. Expert Opinion on Drug Delivery
- Chitin extraction from shrimp shell using enzymatic treatment. Antitumor, antioxidant and antimicrobial activities of chitosan
- (2014) Islem Younes et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
- (2014) Piergiorgio Gentile et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- PEG–PLGA copolymers: Their structure and structure-influenced drug delivery applications
- (2014) Keru Zhang et al. JOURNAL OF CONTROLLED RELEASE
- Synergistic Dual-Ligand Doxorubicin Liposomes Improve Targeting and Therapeutic Efficacy of Brain Glioma in Animals
- (2014) Taili Zong et al. MOLECULAR PHARMACEUTICS
- Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo
- (2014) Xidong Wu et al. PLoS One
- On-Chip Fabrication of Paclitaxel-Loaded Chitosan Nanoparticles for Cancer Therapeutics
- (2013) Fatemeh Sadat Majedi et al. ADVANCED FUNCTIONAL MATERIALS
- B6 Peptide-Modified PEG-PLA Nanoparticles for Enhanced Brain Delivery of Neuroprotective Peptide
- (2013) Zhongyang Liu et al. BIOCONJUGATE CHEMISTRY
- Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles
- (2013) Yung-Chih Kuo et al. BIOMATERIALS
- Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration
- (2013) Zhongyang Liu et al. BIOMATERIALS
- Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway
- (2013) Magdiel I. Setyawati et al. BIOMATERIALS
- LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma
- (2013) Bo Zhang et al. BIOMATERIALS
- Cationic core–shell nanoparticles with carmustine contained within O6-benzylguanine shell for glioma therapy
- (2013) Lili Qian et al. BIOMATERIALS
- Nanoparticles of 2-deoxy-d-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment
- (2013) Xinyi Jiang et al. BIOMATERIALS
- A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box
- (2013) Luca Cucullo et al. BMC NEUROSCIENCE
- Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy
- (2013) Lingyan Shi et al. JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
- Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution
- (2013) Antonietta Vilella et al. JOURNAL OF CONTROLLED RELEASE
- Transferrin receptor antibody-modified α-cobrotoxin-loaded nanoparticles enable drug delivery across the blood–brain barrier by intranasal administration
- (2013) Lin Liu et al. JOURNAL OF NANOPARTICLE RESEARCH
- Development and evaluation of brain targeted intranasal alginate nanoparticles for treatment of depression
- (2013) Shadabul Haque et al. JOURNAL OF PSYCHIATRIC RESEARCH
- 68Ga-Labeled Gold Glyconanoparticles for Exploring Blood–Brain Barrier Permeability: Preparation, Biodistribution Studies, and Improved Brain Uptake via Neuropeptide Conjugation
- (2013) Jens Frigell et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Microfluidic titer plate for stratified 3D cell culture
- (2013) Sebastiaan J. Trietsch et al. LAB ON A CHIP
- Nanoparticle accumulation and transcytosis in brain endothelial cell layers
- (2013) Dong Ye et al. Nanoscale
- Strategies for advancing cancer nanomedicine
- (2013) Vikash P. Chauhan et al. NATURE MATERIALS
- Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery
- (2013) Sneha A. Kulkarni et al. PHARMACEUTICAL RESEARCH
- Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
- (2013) D. T. Wiley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
- (2013) J. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium
- (2013) P. Kolhar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo SELEX for Identification of Brain-penetrating Aptamers
- (2013) Congsheng Cheng et al. Molecular Therapy-Nucleic Acids
- Analytical and Biological Methods for Probing the Blood-Brain Barrier
- (2012) Courtney D. Kuhnline Sloan et al. Annual Review of Analytical Chemistry
- The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
- (2012) Alexandre Albanese et al. Annual Review of Biomedical Engineering
- In Vitro Assessment of Alkylglyceryl-Functionalized Chitosan Nanoparticles as Permeating Vectors for the Blood–Brain Barrier
- (2012) Chun-Fu Lien et al. BIOMACROMOLECULES
- A reverse complementary multimodal imaging system to visualize microRNA9-involved neurogenesis using peptide targeting transferrin receptor-conjugated magnetic fluorescence nanoparticles
- (2012) Mi-hee Jo et al. BIOMATERIALS
- Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor
- (2012) Roger Prades et al. BIOMATERIALS
- Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
- (2012) Hongliang Xin et al. BIOMATERIALS
- BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
- (2012) L. M. Griep et al. BIOMEDICAL MICRODEVICES
- Overview and introduction: The blood-brain barrier in health and disease
- (2012) N. Joan Abbott et al. EPILEPSIA
- Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles
- (2012) Jinghua Duan et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Enhanced preclinical efficacy of tamoxifen developed as alginate–cysteine/disulfide bond reduced albumin nanoparticles
- (2012) A. Martínez et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Comparative Receptor Based Brain Delivery of Tramadol-Loaded Poly(lactic-co-glycolic acid) Nanoparticles
- (2012) Jigar Lalani et al. Journal of Biomedical Nanotechnology
- Amphiphilic HPMA–LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity
- (2012) Mirjam Hemmelmann et al. JOURNAL OF CONTROLLED RELEASE
- Tissue Plasminogen Activator and Stroke: Review of the Literature for the Clinician
- (2012) Gerard DeMers et al. JOURNAL OF EMERGENCY MEDICINE
- OX26 modified hyperbranched polyglycerol-conjugated poly(lactic-co-glycolic acid) nanoparticles: synthesis, characterization and evaluation of its brain delivery ability
- (2012) Hanmei Bao et al. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
- Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB)
- (2012) Jörg Kreuter JOURNAL OF MICROENCAPSULATION
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- (2012) Candace C. Fleischer et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
- (2012) Ross Booth et al. LAB ON A CHIP
- SyM-BBB: a microfluidic blood brain barrier model
- (2012) Balabhaskar Prabhakarpandian et al. LAB ON A CHIP
- A modular approach to create a neurovascular unit-on-a-chip
- (2012) Anil Kumar H. Achyuta et al. LAB ON A CHIP
- Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft
- (2012) Kevin S. Chu et al. Nanomedicine-Nanotechnology Biology and Medicine
- Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses
- (2012) Zhou J. Deng et al. Nanotoxicology
- Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier
- (2011) Huihui Yan et al. ACS Nano
- The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance, and Biocompatibility in Vivo
- (2011) Xinglu Huang et al. ACS Nano
- Modern methods for delivery of drugs across the blood–brain barrier
- (2011) Yan Chen et al. ADVANCED DRUG DELIVERY REVIEWS
- Polymeric nanoparticles for drug delivery to the central nervous system
- (2011) Toral Patel et al. ADVANCED DRUG DELIVERY REVIEWS
- Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
- (2011) Hongliang Xin et al. BIOMATERIALS
- Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides
- (2011) Jingwei Li et al. BIOMATERIALS
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- (2011) Hongliang Xin et al. BIOMATERIALS
- Chitosan–glutathione conjugate-coated poly(butyl cyanoacrylate) nanoparticles: Promising carriers for oral thymopentin delivery
- (2011) Xuefeng Jin et al. CARBOHYDRATE POLYMERS
- Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength
- (2011) Hong Cai et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: Preparation, characterization and efficacy in Parkinson's disease
- (2011) Kaili Hu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Adenosine Receptor Signaling Modulates Permeability of the Blood-Brain Barrier
- (2011) A. J. Carman et al. JOURNAL OF NEUROSCIENCE
- Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models
- (2011) Kathryn Hatherell et al. JOURNAL OF NEUROSCIENCE METHODS
- In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies
- (2011) Pooja Naik et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Biomedical applications of biodegradable polymers
- (2011) Bret D. Ulery et al. JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
- Phaseguides: a paradigm shift in microfluidic priming and emptying
- (2011) Paul Vulto et al. LAB ON A CHIP
- Nanoparticle PEGylation for imaging and therapy
- (2011) Jesse V Jokerst et al. Nanomedicine
- Alginate: Properties and biomedical applications
- (2011) Kuen Yong Lee et al. PROGRESS IN POLYMER SCIENCE
- ABC Transporters and Drug Efflux at the Blood-Brain Barrier
- (2011) Shanshan Shen et al. REVIEWS IN THE NEUROSCIENCES
- Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
- (2011) Hirenkumar K. Makadia et al. Polymers
- Doxorubicin Release Triggered by Alginate Embedded Magnetic Nanoheaters: A Combined Therapy
- (2010) Séverine Brulé et al. ADVANCED MATERIALS
- Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
- (2010) Katrin Knop et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2010) Yang Liu et al. BIOMATERIALS
- Transferrin-conjugated nanoparticles of Poly(lactide)-d-α-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood–brain barrier
- (2010) Chee Wee Gan et al. BIOMATERIALS
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- (2010) Kaori Tsukakoshi et al. BIOTECHNOLOGY LETTERS
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- (2010) Ji-Sheng Yang et al. CARBOHYDRATE POLYMERS
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- (2010) Luca Cucullo et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
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- (2010) Nishit Doshi et al. JOURNAL OF CONTROLLED RELEASE
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- (2010) Kun Shao et al. JOURNAL OF CONTROLLED RELEASE
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- (2010) Sejin Son et al. JOURNAL OF CONTROLLED RELEASE
- Development and evaluation of polymer nanoparticles for oral delivery of estradiol to rat brain in a model of Alzheimer's pathology
- (2010) G. Mittal et al. JOURNAL OF CONTROLLED RELEASE
- Biopharmaceutical drug targeting to the brain
- (2010) William M. Pardridge JOURNAL OF DRUG TARGETING
- Poly(ethylene glycol)-block-poly(d,l-lactide acid) micelles anchored with angiopep-2 for brain-targeting delivery
- (2010) Jie Shen et al. JOURNAL OF DRUG TARGETING
- Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)
- (2010) Karsten Ulbrich et al. JOURNAL OF DRUG TARGETING
- Periodic Incorporation of Pendant Hydroxyl Groups in Repeating Sequence PLGA Copolymers
- (2010) Ryan M. Stayshich et al. MACROMOLECULAR RAPID COMMUNICATIONS
- Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging
- (2010) Robert D. Bell et al. NEURON
- The return of a forgotten polymer—Polycaprolactone in the 21st century
- (2010) Maria Ann Woodruff et al. PROGRESS IN POLYMER SCIENCE
- Biodegradation, biodistribution and toxicity of chitosan
- (2009) T. Kean et al. ADVANCED DRUG DELIVERY REVIEWS
- Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model
- (2009) Chun-Xia Wang et al. BRAIN RESEARCH
- Efficacy of surface charge in targeting pegylated nanoparticles of sulpiride to the brain
- (2009) Tapan Parikh et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters
- (2009) Svetlana Gelperina et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?
- (2009) Anja Graf et al. Expert Opinion on Drug Delivery
- Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood–brain barrier
- (2009) Jiang Chang et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
- (2009) Kamila B. Kurakhmaeva et al. JOURNAL OF DRUG TARGETING
- Flexible Filaments forin VivoImaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage
- (2009) David A. Christian et al. MOLECULAR PHARMACEUTICS
- The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity
- (2009) Fei Yan et al. Nanomedicine-Nanotechnology Biology and Medicine
- Polyalkylcyanoacrylate nanoparticles for delivery of drugs across the blood-brain barrier
- (2009) Karine Andrieux et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Quinoline-n -butylcyanoacrylate-based nanoparticles for brain targeting for the diagnosis of Alzheimer's disease
- (2009) Padmakar V. Kulkarni et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- CNS Delivery Via Adsorptive Transcytosis
- (2008) Françoise Hervé et al. AAPS Journal
- TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs
- (2008) Kavitha S. Rao et al. BIOMATERIALS
- Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
- (2008) Leah R Hanson et al. BMC NEUROSCIENCE
- Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
- (2008) S. Syvanen et al. DRUG METABOLISM AND DISPOSITION
- Delivery of nanoparticles to the brain detected by fluorescence microscopy
- (2008) Isolde Reimold et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
- (2008) Adrienne M. Gorman JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26
- (2008) Zhiqing Pang et al. JOURNAL OF CONTROLLED RELEASE
- Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector Angiopep-2
- (2008) Michel Demeule et al. JOURNAL OF NEUROCHEMISTRY
- Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells
- (2008) Hemant Sarin et al. Journal of Translational Medicine
- Non-invasive measurement of solute permeability in cerebral microvessels of the rat
- (2008) Wei Yuan et al. MICROVASCULAR RESEARCH
- A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
- (2008) Shinsuke Nakagawa et al. NEUROCHEMISTRY INTERNATIONAL
- Structural and Thermodynamic Approach to Peptide Immunogenicity
- (2008) Carlos J. Camacho et al. PLoS Computational Biology
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