标题
The dendrimer paradox – high medical expectations but poor clinical translation
作者
关键词
-
出版物
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 12, Pages 4131-4144
出版商
Royal Society of Chemistry (RSC)
发表日期
2015-05-14
DOI
10.1039/c5cs00288e
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential
- (2014) Nishi Mody et al. AAPS PHARMSCITECH
- Drug-Induced Morphology Switch in Drug Delivery Systems Based on Poly(2-oxazoline)s
- (2014) Anita Schulz et al. ACS Nano
- Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation
- (2014) Mallory A. van Dongen et al. BIOMACROMOLECULES
- Generation dependent cancer targeting potential of poly(propyleneimine) dendrimer
- (2014) Prashant Kesharwani et al. BIOMATERIALS
- Amphiphilic Cationic Carbosilane–PEG Dendrimers: Synthesis and Applications in Gene Therapy
- (2014) Javier Sánchez-Nieves et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Polymer therapeutics: Top 10 selling pharmaceuticals — What next?
- (2014) Ruth Duncan JOURNAL OF CONTROLLED RELEASE
- Enzyme-Responsive Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart Micellar Nanocarriers
- (2014) Assaf J. Harnoy et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- AB3 building blocks for the synthesis of polyester dendrimers
- (2014) Jean-d’Amour K. Twibanire et al. TETRAHEDRON LETTERS
- Hyperbranched polydendrons: a new controlled macromolecular architecture with self-assembly in water and organic solvents
- (2014) Fiona L. Hatton et al. Chemical Science
- Combination of Orthogonal ABB and ABC Multicomponent Reactions toward Efficient Divergent Synthesis of Dendrimers with Structural Diversity
- (2014) Xin-Xing Deng et al. ACS Macro Letters
- Dendrimers for drug delivery
- (2014) Anne-Marie Caminade et al. Journal of Materials Chemistry B
- Stealth Polymeric Vesicles via Metal-Free Click Coupling
- (2013) Michael J. Isaacman et al. BIOMACROMOLECULES
- Design considerations for PAMAM dendrimer therapeutics
- (2013) Sascha N. Goonewardena et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions
- (2013) Naresh Kottari et al. CHEMICAL COMMUNICATIONS
- Dendronized polystyrene via orthogonal double-click reactions
- (2013) Murat Tonga et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins
- (2013) Virgil Percec et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Multifunctional Poly(ethylene glycol): Synthesis, Characterization, and Potential Applications of Dendritic–Linear–Dendritic Block Copolymer Hybrids
- (2013) Oliver C. J. Andrén et al. MACROMOLECULES
- Design, Synthesis and Biological Assessment of a Triazine Dendrimer with Approximately 16 Paclitaxel Groups and 8 PEG Groups
- (2013) Changsuk Lee et al. MOLECULAR PHARMACEUTICS
- Theranostics: Are We There Yet?
- (2013) Sonke Svenson MOLECULAR PHARMACEUTICS
- C–C bond fragmentation by Grob/Eschenmoser reactions, applications in dendrimer synthesis
- (2013) Judith Hierold et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Synthesis of novel polyesteramine dendrimers by divergent and convergent methods
- (2013) Hitoshi Akiyama et al. TETRAHEDRON
- Copper in dendrimer synthesis and applications of copper–dendrimer systems in catalysis: a concise overview
- (2013) Nabil El Brahmi et al. TETRAHEDRON
- Dendrimers in biomedical applications—reflections on the field
- (2012) Sönke Svenson et al. ADVANCED DRUG DELIVERY REVIEWS
- Advanced drug delivery devices via self-assembly of amphiphilic block copolymers
- (2012) Annette Rösler et al. ADVANCED DRUG DELIVERY REVIEWS
- PEGylated nanoparticles for biological and pharmaceutical applications
- (2012) Hidenori Otsuka et al. ADVANCED DRUG DELIVERY REVIEWS
- Liposomal drug delivery systems: From concept to clinical applications
- (2012) Theresa M. Allen et al. ADVANCED DRUG DELIVERY REVIEWS
- Hyperbranched Polyglycerols as Trimodal Imaging Agents: Design, Biocompatibility, and Tumor Uptake
- (2012) Katayoun Saatchi et al. BIOCONJUGATE CHEMISTRY
- Orthogonality in organic, polymer, and supramolecular chemistry: from Merrifield to click chemistry
- (2012) Chun-Ho Wong et al. CHEMICAL COMMUNICATIONS
- Simplifying the synthesis of dendrimers: accelerated approaches
- (2012) Marie V. Walter et al. CHEMICAL SOCIETY REVIEWS
- Design of polymeric nanoparticles for biomedical delivery applications
- (2012) Mahmoud Elsabahy et al. CHEMICAL SOCIETY REVIEWS
- Clinical translation of nanomedicines
- (2012) Sonke Svenson CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
- Biofunctional nanosystems based on dendritic polymers
- (2012) Mohiuddin A. Quadir et al. JOURNAL OF CONTROLLED RELEASE
- Facile synthesis of dendrimers combining aza-Michael addition with Thiol-yne click chemistry
- (2012) Yong Shen et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Highly efficient divergent synthesis of dendrimers via metal-free “click” chemistry
- (2012) Ferdinand Gonzaga et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- In Vitro Transfection Mediated by Dendrigraft Poly(L-lysines): The Effect of Structure and Molecule Size
- (2012) Jakub Hofman et al. MACROMOLECULAR BIOSCIENCE
- Synthesis of Dendronized Polymers by a “n + 2” Approach
- (2012) Hao Yu et al. MACROMOLECULES
- Synthesis of degradable bifunctional dendritic polymers as versatile drug carriers
- (2012) Xinpeng Ma et al. Polymer Chemistry
- Synthesis of Rod-Like Dendronized Polymers Containing G4 and G5 Ester Dendrons via Macromonomer Approach by Living ROMP
- (2012) Kyung Oh Kim et al. ACS Macro Letters
- Click Dendrimers and Triazole-Related Aspects: Catalysts, Mechanism, Synthesis, and Functions. A Bridge between Dendritic Architectures and Nanomaterials
- (2011) Didier Astruc et al. ACCOUNTS OF CHEMICAL RESEARCH
- The effects of polymeric nanostructure shape on drug delivery
- (2011) Shrinivas Venkataraman et al. ADVANCED DRUG DELIVERY REVIEWS
- Efficient Orthogonal Bioconjugation of Dendrimers for Synthesis of Bioactive Nanoparticles
- (2011) Hubert F. Gaertner et al. BIOCONJUGATE CHEMISTRY
- Polyoxazoline: Chemistry, Properties, and Applications in Drug Delivery
- (2011) Tacey X. Viegas et al. BIOCONJUGATE CHEMISTRY
- Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
- (2011) Yiyun Cheng et al. CHEMICAL SOCIETY REVIEWS
- “Clicking” on/with polymers: a rapidly expanding field for the straightforward preparation of novel macromolecular architectures
- (2011) Kristian Kempe et al. CHEMICAL SOCIETY REVIEWS
- Reactions under the Click Chemistry Philosophy Employed in Supramolecular and Mechanostereochemical Systems
- (2011) Albert C. Fahrenbach et al. Chemistry-An Asian Journal
- Clickable dendronized copolymers for introducing structural heterogeneity
- (2011) Xingquan Xiong et al. EUROPEAN POLYMER JOURNAL
- Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell
- (2011) Marcelo Calderón et al. JOURNAL OF CONTROLLED RELEASE
- Development of self-immolative dendrimers for drug delivery and sensing
- (2011) Rongsheng E. Wang et al. JOURNAL OF CONTROLLED RELEASE
- Novel macrothiols for the synthesis of a structurally comprehensive dendritic library using thiol-ene click chemistry
- (2011) Marie V. Walter et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Degradable Self-Assembling Dendrons for Gene Delivery: Experimental and Theoretical Insights into the Barriers to Cellular Uptake
- (2011) Anna Barnard et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of First- and Second-Generation Poly(amide)-Dendronized Polymers via Ring-Opening Metathesis Polymerization
- (2011) Hwayoon Jung et al. MACROMOLECULES
- Filamentous, Mixed Micelles of Triblock Copolymers Enhance Tumor Localization of Indocyanine Green in a Murine Xenograft Model
- (2011) Tae Hee Kim et al. MOLECULAR PHARMACEUTICS
- Nanomedicine(s) under the Microscope
- (2011) Ruth Duncan et al. MOLECULAR PHARMACEUTICS
- A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems
- (2011) Lisa M. Kaminskas et al. Nanomedicine-Nanotechnology Biology and Medicine
- Non-charged, water soluble dendronized polymers
- (2011) Baozhong Zhang et al. NEW JOURNAL OF CHEMISTRY
- Construction of a Well-Defined Multifunctional Dendrimer for Theranostics
- (2011) Cátia Ornelas et al. ORGANIC LETTERS
- A leptin derived 30-amino-acid peptide modified pegylated poly-l-lysine dendrigraft for brain targeted gene delivery
- (2010) Yang Liu et al. BIOMATERIALS
- Facile access to internally functionalized dendrimers through efficient and orthogonal click reactions
- (2010) Taegon Kang et al. CHEMICAL COMMUNICATIONS
- “Click” methodologies: efficient, simple and greener routes to design dendrimers
- (2010) Grégory Franc et al. CHEMICAL SOCIETY REVIEWS
- Cu-free click cycloaddition reactions in chemical biology
- (2010) John C. Jewett et al. CHEMICAL SOCIETY REVIEWS
- Biomedical applications of dendrimers: a tutorial
- (2010) Meredith A. Mintzer et al. CHEMICAL SOCIETY REVIEWS
- Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications
- (2010) Anupa R. Menjoge et al. DRUG DISCOVERY TODAY
- The power of thiol-ene chemistry
- (2010) Matthew J. Kade et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Strain-Promoted Alkyne Azide Cycloaddition for the Functionalization of Poly(amide)-Based Dendrons and Dendrimers
- (2010) Cátia Ornelas et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Pushing the Limits for Thiol−Ene and CuAAC Reactions: Synthesis of a 6th Generation Dendrimer in a Single Day
- (2010) Per Antoni et al. MACROMOLECULES
- Thiol−Ene Click Functionalization and Subsequent Polymerization of 2-Oxazoline Monomers
- (2010) Mallory A. Cortez et al. MACROMOLECULES
- Accelerated Growth of Dendrimers via Thiol−Ene and Esterification Reactions
- (2010) Maria I. Montañez et al. MACROMOLECULES
- Dendritic Polyglycerols for Biomedical Applications
- (2009) Marcelo Calderón et al. ADVANCED MATERIALS
- Bifunctional Dendrimers: From Robust Synthesis and Accelerated One-Pot Postfunctionalization Strategy to Potential Applications
- (2009) Per Antoni et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Development of enzymatically cleavable prodrugs derived from dendritic polyglycerol
- (2009) Marcelo Calderón et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials
- (2009) Rhiannon K. Iha et al. CHEMICAL REVIEWS
- Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems
- (2009) Brad M. Rosen et al. CHEMICAL REVIEWS
- An Expeditious Multigram-Scale Synthesis of Lysine Dendrigraft (DGL) Polymers by AqueousN-Carboxyanhydride Polycondensation
- (2009) Hélène Collet et al. CHEMISTRY-A EUROPEAN JOURNAL
- Dendrimers: Emerging polymers for drug-delivery systems
- (2009) Basavaraj K. Nanjwade et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Synthesis of dendrimers through divergent iterative thio-bromo “Click” chemistry
- (2009) Brad M. Rosen et al. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
- (2009) Andrew B. Lowe Polymer Chemistry
- The 8 year thicket of triazine dendrimers: strategies, targets and applications
- (2009) E. E. Simanek et al. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
- New methodologies in the construction of dendritic materials
- (2008) Anna Carlmark et al. CHEMICAL SOCIETY REVIEWS
- Dendrimers as Biopharmaceuticals: Synthesis and Properties
- (2008) Carolina Villalonga-Barber et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Hyperbranched polymers for controlled release of cisplatin
- (2008) Katherine J. Haxton et al. DALTON TRANSACTIONS
- Dendrimers as versatile platform in drug delivery applications
- (2008) Sonke Svenson EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumor-specific treatment and imaging?
- (2008) Maha Saad et al. JOURNAL OF CONTROLLED RELEASE
- Hybrid linear dendritic macromolecules: From synthesis to applications
- (2008) Ivan Gitsov JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
- Janus-Type Dendrimer-like Poly(ethylene oxide)s
- (2008) Xiaoshuang Feng et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Synthesis of Nanoparticle-Cored Dendrimers by Convergent Dendritic Functionalization of Monolayer-Protected Nanoparticles
- (2008) Young-Seok Shon et al. LANGMUIR
- Construction of Linear Polymers, Dendrimers, Networks, and Other Polymeric Architectures by Copper‐Catalyzed Azide‐Alkyne Cycloaddition “Click” Chemistry
- (2008) Jeremiah A. Johnson et al. MACROMOLECULAR RAPID COMMUNICATIONS
- Dendrimers for enhanced drug solubilization
- (2008) Sonke Svenson et al. Nanomedicine
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