A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

Basics and principles of cellular and systemic iron homeostasis

(2020) Angeliki Katsarou et al.   MOLECULAR ASPECTS OF MEDICINE

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

(2019) Seon Ju Mun et al.   JOURNAL OF HEPATOLOGY

Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes

(2019) Lulu Sun et al.   NATURE CELL BIOLOGY

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

(2019) Shuyong Wang et al.   CELL RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome

(2018) Ran Jing et al.   Cell Reports

Overview of iron metabolism in health and disease

(2017) Som Dev et al.   Hemodialysis International

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Deoxyguanosine kinase deficiency: a report of four patients

(2017) Özlem Ünal et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Iron metabolism and related genetic diseases: A cleared land, keeping mysteries

(2016) Pierre Brissot et al.   JOURNAL OF HEPATOLOGY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model

(2015) Shengbiao Li et al.   HEPATOLOGY

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

(2015) Kívia de Andrade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Mitochondrial Depletion Syndromes in Children and Adults

(2014) Josef Finsterer et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Novel Deoxyguanosine Kinase Gene Mutations in the Hepatocerebral Form of Mitochondrial DNA Depletion Syndrome

(2014) Taner Sezer et al.   JOURNAL OF CHILD NEUROLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity

(2012) Alexandra Kollara et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NK Cell Genesis: A Trick of the Trail

(2012) Emilie Narni-Mancinelli et al.   IMMUNITY

Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis

(2011) Neil A. Hanchard et al.   MOLECULAR GENETICS AND METABOLISM

Post mortem identification of deoxyguanosine kinase (DGUOK) gene mutations combined with impaired glucose homeostasis and iron overload features in four infants with severe progressive liver failure

(2010) Ewa Pronicka et al.   JOURNAL OF APPLIED GENETICS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY