Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis

Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death

(2020) Maria C. Tanzer et al.   Cell Reports

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

(2020) Catherine R. Lammert et al.   NATURE

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

(2019) Victor S. Tapia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse small molecules prevent macrophage lysis during pyroptosis

(2019) Wendy P. Loomis et al.   Cell Death & Disease

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

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The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

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The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

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The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

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Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From Inflammasome to Exosome—Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

(2018) Wojciech Cypryk et al.   Frontiers in Immunology

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β

(2017) David Brough et al.   JOURNAL OF CELL SCIENCE

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

(2017) Zhirong Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Performance Evaluation of the Q Exactive HF-X for Shotgun Proteomics

(2017) Christian D. Kelstrup et al.   JOURNAL OF PROTEOME RESEARCH

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

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Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration

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Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Mass-spectrometric exploration of proteome structure and function

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The Perseus computational platform for comprehensive analysis of (prote)omics data

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Mechanisms of unconventional secretion of IL-1 family cytokines

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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Multidimensional proteomics for cell biology

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The Pfam protein families database: towards a more sustainable future

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Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

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Direct Proteomic Quantification of the Secretome of Activated Immune Cells

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SprayQc: A Real-Time LC–MS/MS Quality Monitoring System To Maximize Uptime Using Off the Shelf Components

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ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

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Understanding the mechanism of IL-1β secretion

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Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

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Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation

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Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

System-wide Perturbation Analysis with Nearly Complete Coverage of the Yeast Proteome by Single-shot Ultra HPLC Runs on a Bench Top Orbitrap

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Non-canonical inflammasome activation targets caspase-11

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Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

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Cytokine secretion in macrophages and other cells: Pathways and mediators

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Golgicide A reveals essential roles for GBF1 in Golgi assembly and function

(2009) José B Sáenz et al.   Nature Chemical Biology

Pyroptosis: host cell death and inflammation

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Mechanisms of regulated unconventional protein secretion

(2009) Walter Nickel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY