Editorial Material
Cell Biology
Qi Wu, Ai-Ling Tian, Guido Kroemer, Oliver Kepp
Summary: The study suggests that IGF1R inhibitors can enhance immunogenic cancer cell death and immune recognition by inducing autophagy, thus improving the therapeutic efficacy in cancer treatment. In vitro experiments showed that PPP and linsitinib, as IGF1R inhibitors, can enhance the release of ATP from stressed and dying cancer cells.
Editorial Material
Cell Biology
Clint A. Stalnecker, Michael F. Coleman, Kirsten L. Bryant
Summary: Pancreatic ductal adenocarcinoma (PDAC) relies on macroautophagy/autophagy, but autophagy inhibitors as monotherapy have limited efficacy. Through genetic loss-of-function screening, IGF1R was identified as a sensitizer that increases sensitivity to autophagy inhibitors. Simultaneous inhibition of IGF1R and MAPK/ERK signaling further enhances the sensitivity.
Article
Multidisciplinary Sciences
Fei Li, Ming Han, Pengfei Dai, Wei Xu, Juan He, Xiaoting Tao, Yang Wu, Xinyuan Tong, Xinyi Xia, Wangxin Guo, Yunjiao Zhou, Yunguang Li, Yiqin Zhu, Xiaoyu Zhang, Zhuang Liu, Rebiguli Aji, Xia Cai, Yutang Li, Di Qu, Yu Chen, Shibo Jiang, Qiao Wang, Hongbin Ji, Youhua Xie, Yihua Sun, Lu Lu, Dong Gao
Summary: Enzalutamide effectively inhibited SARS-CoV-2 infection in human prostate cells, however, such antiviral efficacy was lacking in human lung cells and organoids.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Menghang Huang, Xiaoxiao Zhang, Gee Ann Toh, Qin Gong, Jia Wang, Zhifu Han, Bin Wu, Franklin Zhong, Jijie Chai
Summary: The study demonstrates that full-length rat NLRP1 and rat DPP9 can form a complex to suppress NLRP1 activation. The ZU5 domain is essential for both autoinhibition of NLRP1 and assembly of the complex. Furthermore, both NLRP1 binding and enzymatic activity are required for DPP9 to suppress NLRP1 in human cells.
Review
Endocrinology & Metabolism
Joseph J. Bulatowicz, Teresa L. Wood
Summary: IGF1R plays a dual role in breast cancer, with both tumor-promoting and potentially tumor-suppressing effects. Understanding the function of IGF1R in cellular growth, proliferation, and differentiation provides insights into the seemingly conflicting reports. This review summarizes the existing data and proposes hypotheses regarding the role of IGF1R in mammary development, tumorigenesis, and metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yiguo Zhang, Yixin Jing, Rui Pan, Ke Ding, Rong Chen, Qingtao Meng
Summary: Local anesthetics play a crucial role in perioperative analgesia for cancer patients, as they have been shown to reduce tumor recurrence and proliferation through various mechanisms. Clinical evidence and randomized trial data support the inhibitory effect of local anesthetics on tumor progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Christine E. Lehman, Adam Spencer, Sarah Hall, Jeremy J. P. Shaw, Julia Wulfkuhle, Emanuel F. Petricoin, Stefan Bekiranov, Mark J. Jameson, Daniel Gioeli
Summary: Research indicates that targeting FAK and Paxillin phosphorylation in the focal adhesion signaling pathway may enhance therapeutic responses in HNSCC cells treated with IGF1R and Src inhibitors. Experimental results demonstrate that the combination of BMS754807 and dasatinib shows significant efficacy in multiple models, potentially offering therapeutic potential in HNSCC patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Michael F. Coleman, Runying Yang, Jonathan M. DeLiberty, Bjorn Papke, Craig M. Goodwin, Mariaelena Pierobon, Emanuel F. Petricoin, Prson Gautam, Krister Wennerberg, Adrienne D. Cox, Channing J. Der, Stephen D. Hursting, Kirsten L. Bryant
Summary: Pancreatic ductal adenocarcinoma (PDAC) is aggressive and requires improved therapies. Recent research has shown that autophagy, a macrometabolic process, is upregulated in PDAC and essential for its growth. However, the clinical efficacy of autophagy inhibition as a monotherapy is limited. Targeting both insulin-like growth factor 1 receptor (IGF1R) and pathways that oppose autophagy, such as the ERK-MAPK axis, can enhance the effectiveness of autophagy inhibitors in PDAC.
Article
Biochemistry & Molecular Biology
Xiaoshen Wang, Xuzichao Li, Yongjian Ma, Jiaqi He, Xiang Liu, Guimei Yu, Hang Yin, Heng Zhang
Summary: Mobile genetic elements have developed anti-CRISPR proteins like Acrs to suppress CRISPR-Cas adaptive immune systems. Recent research has identified AcrIIA17 and AcrIIA18 as inhibitors of Cas9 through modulation of sgRNA. AcrIIA17 interferes with Cas9-sgRNA complex formation, while AcrIIA18 induces sgRNA truncation in a Cas9-dependent manner, shedding light on new mechanisms of CRISPR-Cas9 inhibition by Acrs.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. Sobolevsky
Summary: TRPV6 is a calcium-selective ion channel with potential as a drug target. The study presents cryo-EM structures of TRPV6 with inhibitors ruthenium red and econazole, revealing their mechanisms of inhibition. Both inhibitors induce conformational changes in TRPV6, guiding the design of new inhibitors.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Ruirui Gui, Wanqiao Li, Zhipeng Li, Hongbin Wang, Yuchen Wu, Wenlin Jiao, Gang Zhao, Yannan Shen, Luping Wang, Jialu Zhang, Sihan Chen, Linlin Hao, Yunyun Cheng
Summary: Liver fibrosis is a reversible wound-healing response caused by persistent liver damage. This review focuses on the role of insulin-like growth factor 1 (IGF1) and its receptor (IGF1R) in liver fibrosis, including their involvement in DNA damage repair, cell senescence, lipid metabolism, and oxidative stress. The review also examines the signaling pathways and cell species influenced by IGF1 and IGF1R under different conditions. The findings provide a basis for studying the effect of IGF1/IGF1R on liver fibrosis and the communication between different types of liver cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Sven M. Lange, Lee A. Armstrong, Yogesh Kulathu
Summary: This review summarizes the multiple layers of regulation that control autoinhibition, activation, and substrate specificity of DUBs. It discusses different strategies to inhibit DUBs and the progress in developing selective small-molecule DUB inhibitors. It also proposes a classification system of DUB inhibitors based on their mode of action.
Article
Chemistry, Multidisciplinary
Alejandra Mier, Irene Maffucci, Franck Merlier, Elise Prost, Valentina Montagna, Guillermo U. Ruiz-Esparza, Joseph V. Bonventre, Pradeep K. Dhal, Bernadette Tse Sum Bui, Peyman Sakhaii, Karsten Haupt
Summary: The study proposed a computational strategy to identify the best protein epitope and experimentally verified the existence of specific binding sites in MIP nanogel created by imprinting. The optimized MIP nanogel showed high affinity and selectivity towards the epitope and cognate protein.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Immunology
Jonas P. Becker, Angelika B. Riemer
Summary: Immunopeptidomics is crucial for epitope-centric cancer immunotherapies, providing direct proof of cell surface presentation. Despite significant progress in the field, identification of HLA-presented peptides remains challenging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Ballesteros-Sanabria, Hector F. Pelaez-Prestel, Alvaro Ras-Carmona, Pedro A. Reche
Summary: SARS-CoV-2 VOCs, particularly the Omicron variant, may be prone to escape spike-specific antibody immunity elicited by COVID-19 vaccines, but not cellular immunity.