The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized nucleotides

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions

(2019) Yao-Kai Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A polar filter in DNA polymerases prevents ribonucleotide incorporation

(2019) Mary K Johnson et al.   NUCLEIC ACIDS RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Incomplete base excision repair contributes to cell death from antibiotics and other stresses

(2018) Charley C. Gruber et al.   DNA REPAIR

Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate

(2018) Melike Çağlayan et al.   Nature Communications

How DNA polymerases catalyse replication and repair with contrasting fidelity

(2017) Wen-Jin Wu et al.   Nature Reviews Chemistry

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics

(2016) Jithesh Kottur et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

(2016) O. Rechkoblit et al.   Science Advances

Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda

(2015) Matthew J. Burak et al.   NUCLEIC ACIDS RESEARCH

Essential role for polymerase specialization in cellular nonhomologous end joining

(2015) John M. Pryor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage

(2015) Peter Belenky et al.   Cell Reports

Structure–Function Studies of DNA Polymerase λ

(2014) Katarzyna Bebenek et al.   BIOCHEMISTRY

Structure and Mechanism of DNA Polymerase β

(2014) William A. Beard et al.   BIOCHEMISTRY

How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells

(2014) Catherine J. Potenski et al.   NUCLEIC ACIDS RESEARCH

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The active site of TthPolX is adapted to prevent 8-oxo-dGTP misincorporation

(2013) Patricia Garrido et al.   NUCLEIC ACIDS RESEARCH

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

(2013) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Solution Structure of the Dickerson DNA Dodecamer Containing a Single Ribonucleotide

(2012) Eugene F. DeRose et al.   BIOCHEMISTRY

The role of the PHP domain associated with DNA polymerase X from Thermus thermophilus HB8 in base excision repair

(2012) Shuhei Nakane et al.   DNA REPAIR

The Structural Basis of the Kinetic Mechanism of a Gap-Filling X-Family DNA Polymerase That Binds Mg2+-dNTP Before Binding to DNA

(2012) Shuhei Nakane et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

DNA stabilization at the Bacillus subtilis PolX core —a binding model to coordinate polymerase, AP-endonuclease and 3′-5′ exonuclease activities

(2012) Benito Baños et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion

(2012) Bret D. Freudenthal et al.   NUCLEIC ACIDS RESEARCH

The catalytic cycle for ribonucleotide incorporation by human DNA Pol λ

(2012) Rajendrakumar A. Gosavi et al.   NUCLEIC ACIDS RESEARCH

Molecular Insights into DNA Polymerase Deterrents for Ribonucleotide Insertion

(2011) Nisha A. Cavanaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house

(2010) Priyamvada Rai   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine

(2010) William A. Beard et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA Polymerases β and λ Mediate Overlapping and Independent Roles in Base Excision Repair in Mouse Embryonic Fibroblasts

(2010) Elena K. Braithwaite et al.   PLoS One

Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites

(2010) B. Banos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase Family X: Function, structure, and cellular roles

(2009) Jennifer Yamtich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Family X DNA Polymerase fromDeinococcus radioduransAdopts a Non-standard Extended Conformation

(2009) Nicolas Leulliot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism of Sugar Selection Utilized by a Human X-Family DNA Polymerase

(2009) Jessica A. Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

DNA polymerase X from Deinococcus radiodurans implicated in bacterial tolerance to DNA damage is characterized as a short patch base excision repair polymerase

(2009) N. P. Khairnar et al.   MICROBIOLOGY-SGM

Characterization of DNA polymerase X from Thermus thermophilus HB8 reveals the POLXc and PHP domains are both required for 3′–5′ exonuclease activity

(2009) Shuhei Nakane et al.   NUCLEIC ACIDS RESEARCH

Distribution and roles of X-family DNA polymerases in eukaryotes

(2008) Yukinobu Uchiyama et al.   BIOCHIMIE

Characterization of a Bacillus subtilis 64-kDa DNA Polymerase X Potentially Involved in DNA Repair

(2008) Benito Baños et al.   JOURNAL OF MOLECULAR BIOLOGY

Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase

(2008) B. Banos et al.   NUCLEIC ACIDS RESEARCH