Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

A rescue act: Translesion DNA synthesis pastN2-deoxyguanosine adducts

(2015) Deepak T. Nair et al.   IUBMB LIFE

Viewing Human DNA Polymerase β Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography

(2015) Rajan Vyas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique Structural Features in DNA Polymerase IV Enable Efficient Bypass of the N 2 Adduct Induced by the Nitrofurazone Antibiotic

(2015) Jithesh Kottur et al.   STRUCTURE

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

(2014) Bret D. Freudenthal et al.   NATURE

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One Size Does Not Fit All-Bacterial Cell Death by Antibiotics Cannot Be Explained by the Action of Reactive Oxygen Species

(2013) Nikolai Kuhnert   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibiotic and ROS linkage questioned

(2013) Ferric C Fang   NATURE BIOTECHNOLOGY

A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli

(2013) Amit Sharma et al.   NUCLEIC ACIDS RESEARCH

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action

(2012) E. Linley et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis

(2012) Daniel J. Dwyer et al.   MOLECULAR CELL

Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics

(2012) J. J. Foti et al.   SCIENCE

Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota

(2011) K. N. Kirouac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of Oxidative Damage to Antimicrobial Lethality

(2009) X. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of reactive oxygen species in antibiotic action and resistance

(2009) Daniel J Dwyer et al.   CURRENT OPINION IN MICROBIOLOGY

Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion

(2009) Rodrigo Vasquez-Del Carpio et al.   PLoS One

Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases

(2009) Olga Rechkoblit et al.   STRUCTURE