How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Saccharomyces cerevisiae RNase H2 Interaction Network Functions To Suppress Genome Instability

(2014) S. Allen-Soltero et al.   MOLECULAR AND CELLULAR BIOLOGY

Investigating the mechanisms of ribonucleotide excision repair in Escherichia coli

(2014) Alexandra Vaisman et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

(2014) Catherine J. Potenski et al.   NATURE

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

(2014) Constance Alabert et al.   NATURE CELL BIOLOGY

Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast

(2013) Jang-Eun Cho et al.   DNA REPAIR

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

(2013) Jessica S. Williams et al.   MOLECULAR CELL

Ribonucleotides Misincorporated into DNA Act as Strand-Discrimination Signals in Eukaryotic Mismatch Repair

(2013) Medini Manohar Ghodgaonkar et al.   MOLECULAR CELL

Ribonucleotides Are Signals for Mismatch Repair of Leading-Strand Replication Errors

(2013) Scott A. Lujan et al.   MOLECULAR CELL

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

(2013) Percy Tumbale et al.   NATURE

Structure-function analysis of ribonucleotide bypass by B family DNA replicases

(2013) A. R. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates

(2013) E. J. Bartlett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cost of rNTP/dNTP pool imbalance at the replication fork

(2013) N. Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Removal of Misincorporated Ribonucleotides from Prokaryotic Genomes: An Unexpected Role for Nucleotide Excision Repair

(2013) Alexandra Vaisman et al.   PLoS Genetics

Solution Structure of the Dickerson DNA Dodecamer Containing a Single Ribonucleotide

(2012) Eugene F. DeRose et al.   BIOCHEMISTRY

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ

(2012) Anders R. Clausen et al.   DNA REPAIR

Human DNA Polymerase ϵ Is Able to Efficiently Extend from Multiple Consecutive Ribonucleotides

(2012) A. Yasemin Göksenin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

(2012) Bjoern Hiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNase H2-Initiated Ribonucleotide Excision Repair

(2012) Justin L. Sparks et al.   MOLECULAR CELL

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

(2012) Federico Lazzaro et al.   MOLECULAR CELL

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

(2012) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

Critical amino acids in Escherichia coli UmuC responsible for sugar discrimination and base-substitution fidelity

(2012) Alexandra Vaisman et al.   NUCLEIC ACIDS RESEARCH

Unlocking the Sugar “Steric Gate” of DNA Polymerases

(2011) Jessica A. Brown et al.   BIOCHEMISTRY

Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

(2011) Danielle L. Watt et al.   DNA REPAIR

Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ɛ

(2011) Alan B. Clark et al.   DNA REPAIR

Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H

(2011) Ying Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PCNA directs type 2 RNase H activity on DNA replication and repair substrates

(2011) Doryen Bubeck et al.   NUCLEIC ACIDS RESEARCH

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

Identification of a Novel Type of Spacer Element Required for Imprinting in Fission Yeast

(2011) Suha Sayrac et al.   PLoS Genetics

Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

(2010) Georgia Ramantani et al.   ARTHRITIS AND RHEUMATISM

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

A Novel Mechanism of Sugar Selection Utilized by a Human X-Family DNA Polymerase

(2009) Jessica A. Brown et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Bacterial Nonhomologous End Joining Ligases Preferentially Seal Breaks with a 3′-OH Monoribonucleotide

(2008) Hui Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY