Extracellular Chaperones and Proteostasis

Clusterin Interacts with Paclitaxel and Confer Paclitaxel Resistance in Ovarian Cancer

(2015) Dong Choon Park et al.   NEOPLASIA

Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation

(2012) Shinwu Jeong et al.   AMERICAN JOURNAL OF PATHOLOGY

Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

(2012) Jonathan B. Rothbard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Albumin Prevents Protein Aggregation and Amyloid Formation and Retains Chaperone-like Activity in the Presence of Physiological Ligands

(2012) Thomas E. Finn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory-Agency-Approved Drug

(2012) Steven M. Johnson et al.   JOURNAL OF MOLECULAR BIOLOGY

Nanoparticle Hydrophobicity Dictates Immune Response

(2012) Daniel F. Moyano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

(2012) Bengt Winblad et al.   LANCET NEUROLOGY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers

(2012) B. Mannini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αB-Crystallin Improves Murine Cardiac Function and Attenuates Apoptosis in Human Endothelial Cells Exposed to Ischemia-Reperfusion

(2011) Jeffrey B. Velotta et al.   ANNALS OF THORACIC SURGERY

The chaperone action of bovine milk αS1- and αS2-caseins and their associated form αS-casein

(2011) Teresa M. Treweek et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibiting effect of αs1-casein on Aβ1–40 fibrillogenesis

(2011) R. Carrotta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Reliable typing of systemic amyloidoses through proteomic analysis of subcutaneous adipose tissue

(2011) F. Brambilla et al.   BLOOD

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

(2011) Amy R. Wyatt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin

(2011) S Pangratz-Fuehrer et al.   EYE

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

(2011) Franziska Kriegenburg et al.   FEBS Journal

Inhibition of β2-Microglobulin Amyloid Fibril Formation by α2-Macroglobulin

(2011) Daisaku Ozawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusterin Overexpression and Its Possible Protective Role in Transthyretin Deposition in Familial Amyloidotic Polyneuropathy

(2011) Joana Magalhães et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tissue-type plasminogen activator-mediated plasminogen activation and contact activation, implications in and beyond haemostasis

(2011) M. F. B. G. GEBBINK   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity

(2011) Ana Maria Cuervo   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Secreted Protein Acidic and Rich in Cysteine Is a Matrix Scavenger Chaperone

(2011) Alexandre Chlenski et al.   PLoS One

Systemic augmentation of αB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation

(2011) Ahmet Arac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

(2010) Benedetta Bolognesi et al.   ACS Chemical Biology

Suppression of choroid plexus transthyretin levels by antisense oligonucleotide treatment

(2010) Merrill D. Benson et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Inhibition of heat- and chemical-induced aggregation of various proteins reveals chaperone-like activity of the acute-phase component and serine protease inhibitor human α 1 -antitrypsin

(2010) Ferenc Zsila   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2

(2010) Tony Heurtaux et al.   JOURNAL OF NEUROCHEMISTRY

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease

(2010) Elisa Bruno et al.   NEUROSCIENCE LETTERS

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

αEC, the C-Terminal Extension of Fibrinogen, Has Chaperone-like Activity

(2009) Huadong Tang et al.   BIOCHEMISTRY

Chaperone-like activity of the acute-phase component human serum α1-acid glycoprotein: Inhibition of thermal- and chemical-induced aggregation of various proteins

(2009) Ferenc Zsila   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury

(2009) A. L. Samson et al.   BLOOD

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

(2009) M. J. Nielsen et al.   BLOOD

Extracellular chaperones modulate the effects of Alzheimer’s patient cerebrospinal fluid on Aβ1-42 toxicity and uptake

(2009) Justin J. Yerbury et al.   CELL STRESS & CHAPERONES

Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders

(2009) Bruno Vellas et al.   Current Alzheimer Research

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals

(2009) Friederike Flachsbart et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Aggregates of denatured proteins stimulate nitric oxide and superoxide production in macrophages

(2009) Szczepan Jozefowski et al.   INFLAMMATION RESEARCH

Dephosphorylation of αs- and β-Caseins and Its Effect on Chaperone Activity: A Structural and Functional Investigation

(2009) Tomas Koudelka et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural Characterization of Clusterin-Chaperone Client Protein Complexes

(2009) Amy R. Wyatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Soluble aggregates of the amyloid-β peptide are trapped by serum albumin to enhance amyloid-β activation of endothelial cells

(2009) Adriana A Reyes Barcelo et al.   Journal of Biological Engineering

Fibrinogen has chaperone-like activity

(2008) Huadong Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid Fibril Formation by Bovine Milk αs2-Casein Occurs under Physiological Conditions Yet Is Prevented by Its Natural Counterpart, αs1-Casein†

(2008) David C. Thorn et al.   BIOCHEMISTRY

Protease Activation of α2-Macroglobulin Modulates a Chaperone-like Action with Broad Specificity

(2008) Katie French et al.   BIOCHEMISTRY

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

(2008) I. P. Trougakos et al.   CLINICAL CANCER RESEARCH

Human haptoglobin structure and function - a molecular modelling study

(2008) F. Polticelli et al.   FEBS Journal

α2-Macroglobulin and Haptoglobin Suppress Amyloid Formation by Interacting with Prefibrillar Protein Species

(2008) Justin J. Yerbury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissociation from the Oligomeric State Is the Rate-limiting Step in Fibril Formation by κ-Casein

(2008) Heath Ecroyd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

The acute phase protein haptoglobin regulates host immunity

(2008) Kristin M. Huntoon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE