Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

(2016) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats

(2015) Hongyan Dong et al.   ARCHIVES OF TOXICOLOGY

ASSIGN: context-specific genomic profiling of multiple heterogeneous biological pathways

(2015) Ying Shen et al.   BIOINFORMATICS

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells

(2015) Julie K. Buick et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

(2015) Heng-Hong Li et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells

(2015) Cheng Peng et al.   MUTAGENESIS

Identification of Modulators of the Nuclear Receptor Peroxisome Proliferator-Activated Receptor α (PPARα) in a Mouse Liver Gene Expression Compendium

(2015) Keiyu Oshida et al.   PLoS One

In vivo murine hepatic microRNA and mRNA expression signatures predicting the (non-)genotoxic carcinogenic potential of chemicals

(2014) Joost P. M. Melis et al.   ARCHIVES OF TOXICOLOGY

Identification of biomarkers that distinguish chemical contaminants based on gene expression profiles

(2014) Xiaomou Wei et al.   BMC GENOMICS

Big Data in Chemical Toxicity Research: The Use of High-Throughput Screening Assays To Identify Potential Toxicants

(2014) Hao Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An evaluation of 25 selected ToxCast chemicals in medium-throughput assays to detect genotoxicity

(2014) Andrew D. Kligerman et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cellsin vitro

(2014) Peter C. J. Schmeits et al.   JOURNAL OF APPLIED TOXICOLOGY

Cross-Platform Toxicogenomics for the Prediction of Non-Genotoxic Hepatocarcinogenesis in Rat

(2014) Michael Römer et al.   PLoS One

Whole Genome Transcript Profiling of Drug Induced Steatosis in Rats Reveals a Gene Signature Predictive of Outcome

(2014) Nishika Sahini et al.   PLoS One

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices

(2014) Marlon J.A. Jetten et al.   TOXICOLOGY

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

(2013) Tatyana Y. Doktorova et al.   CARCINOGENESIS

Prediction of human genes and diseases targeted by xenobiotics using predictive toxicogenomic-derived models (PTDMs)

(2013) Feixiong Cheng et al.   Molecular BioSystems

Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

(2013) Reuben Thomas et al.   PLoS One

A Toxicogenomic Approach for the Prediction of Murine Hepatocarcinogenesis Using Ensemble Feature Selection

(2013) Johannes Eichner et al.   PLoS One

Use and validation of HT/HC assays to support 21st century toxicity evaluations

(2013) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan

(2013) Anna Francina Jackson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Effect of Chemical Mutagens and Carcinogens on Gene Expression Profiles in Human TK6 Cells

(2012) Lode Godderis et al.   PLoS One

Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats

(2012) Yohsuke Minowa et al.   TOXICOLOGY

In vivo genotoxicity of furan in F344 rats at cancer bioassay doses

(2012) Wei Ding et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro genotoxicity test approaches with better predictivity: Summary of an IWGT workshop

(2011) Stefan Pfuhler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity of furan in Big Blue rats

(2011) L. Patrice McDaniel et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genomic Profiling Uncovers a Molecular Pattern for Toxicological Characterization of Mutagens and Promutagens In Vitro

(2011) Kathleen Boehme et al.   TOXICOLOGICAL SCIENCES

Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database

(2011) Takeki Uehara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

(2010) Federico M. Goodsaid et al.   NATURE REVIEWS DRUG DISCOVERY

Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan

(2010) K. C. Hickling et al.   TOXICOLOGIC PATHOLOGY

Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed a Gene Signature Predictive of Chemical Carcinogens

(2010) Astrid Rohrbeck et al.   TOXICOLOGICAL SCIENCES

Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes

(2009) P. Leopardi et al.   MUTAGENESIS

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/− mouse lymphoma cells

(2008) Marco Kellert et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE