Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system

Evolutionary Conservation of Transcription Factors Affecting Longevity

(2020) Guillermo Martínez Corrales et al.   TRENDS IN GENETICS

Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction

(2020) Amy R Poe et al.   eLife

Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling

(2020) Nathaniel S. Woodling et al.   BMC BIOLOGY

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

(2020) Ivana Bjedov et al.   PLoS Genetics

Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Drosophila

(2019) Allison Birnbaum et al.   Frontiers in Genetics

Longevity is determined by ETS transcription factors in multiple tissues and diverse species

(2019) Adam J. Dobson et al.   PLoS Genetics

A meta-analysis of genome-wide association studies identifies multiple longevity genes

(2019) Joris Deelen et al.   Nature Communications

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

(2018) Kristofer Davie et al.   CELL

FoxA transcription factor Fork head maintains the intestinal stem/progenitor cell identities in Drosophila

(2018) Qing Lan et al.   DEVELOPMENTAL BIOLOGY

Trim33 mediates the proinflammatory function of Th17 cells

(2018) Shinya Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

(2018) Hrvoje Augustin et al.   NEUROBIOLOGY OF AGING

Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

(2018) Álvaro F. Fernández et al.   NATURE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

The glia of the adult Drosophila nervous system

(2017) Malte C. Kremer et al.   GLIA

Future life expectancy in 35 industrialised countries: projections with a Bayesian model ensemble

(2017) Vasilis Kontis et al.   LANCET

A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance

(2017) Luke S Tain et al.   Molecular Systems Biology

Reversing SKI–SMAD4-mediated suppression is essential for TH17 cell differentiation

(2017) Song Zhang et al.   NATURE

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

(2017) Ekin Bolukbasi et al.   Cell Reports

Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

(2017) Hrvoje Augustin et al.   PLOS BIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

(2016) Kerri J. Kinghorn et al.   JOURNAL OF NEUROSCIENCE

The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy

(2016) Krisztina Hegedűs et al.   MOLECULAR BIOLOGY OF THE CELL

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity

(2015) Cathy Slack et al.   CELL

Intestinal FoxO signaling is required to survive oral infection in Drosophila

(2015) C Fink et al.   Mucosal Immunology

The Drosophila Insulin Receptor Independently Modulates Lifespan and Locomotor Senescence

(2015) Mohd Zamri Bin Haji Ismail et al.   PLoS One

Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice

(2015) Alessandro Pristerà et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

(2014) Anne Simonsen et al.   Autophagy

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 inDrosophila

(2014) Péter Nagy et al.   Autophagy

Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila

(2014) Disha Varma et al.   JOURNAL OF INSECT PHYSIOLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

(2014) Linda Broer et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging

(2014) Nazif Alic et al.   Cell Reports

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

(2013) Emilda Pino et al.   HUMAN MOLECULAR GENETICS

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites

(2013) Jason Gertz et al.   MOLECULAR CELL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

FoxO6 regulates memory consolidation and synaptic function

(2012) D. A. M. Salih et al.   GENES & DEVELOPMENT

Detrimental Effects of RNAi: A Cautionary Note on Its Use in Drosophila Ageing Studies

(2012) Nazif Alic et al.   PLoS One

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

Death and dessert: nutrient signalling pathways and ageing

(2011) Nazif Alic et al.   CURRENT OPINION IN CELL BIOLOGY

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

(2010) Nazif Alic et al.   AGING CELL

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk

(2010) Cathy Slack et al.   PLoS Genetics

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

(2009) F. Kerr et al.   NEUROBIOLOGY OF AGING

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL