SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: Implications for osteoarthritis diagnosis and therapy

(2020) Angela Ruscitto et al.   FASEB JOURNAL

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

(2020) Leilei Zhong et al.   eLife

Chondrogenesis Defines Future Skeletal Patterns Via Cell Transdifferentiation from Chondrocytes to Bone Cells

(2020) Yan Jing et al.   Current Osteoporosis Reports

Periarticular Mesenchymal Progenitors Initiate and Contribute to Secondary Ossification Center Formation During Mouse Long Bone Development

(2019) Wei Tong et al.   STEM CELLS

Elevated BMP and mechanical signaling through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis

(2019) Alexandra Stanley et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases

(2019) Sonsoles Piera-Velazquez et al.   PHYSIOLOGICAL REVIEWS

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Persistent Sox9 expression in hypertrophic chondrocytes suppresses transdifferentiation into osteoblasts

(2019) Julian C. Lui et al.   BONE

Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo

(2019) Yuanming Ouyang et al.   Drug Design Development and Therapy

TGFβ/BMP Signaling Pathway in Cartilage Homeostasis

(2019) Nathalie G.M. Thielen et al.   Cells

Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond

(2019) Shawn A. Hallett et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular Plasticity in Musculoskeletal Development, Regeneration, and Disease

(2019) Deepak A. Kaji et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

SOX9 in cartilage development and disease

(2019) Véronique Lefebvre et al.   CURRENT OPINION IN CELL BIOLOGY

Insights into Gene Regulatory Networks in Chondrocytes

(2019) Hironori Hojo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis

(2018) Chia-Feng Liu et al.   DEVELOPMENT

Runx2, an inducer of osteoblast and chondrocyte differentiation

(2018) Toshihisa Komori   HISTOCHEMISTRY AND CELL BIOLOGY

Cartilage diseases

(2018) Yamini Krishnan et al.   MATRIX BIOLOGY

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?

(2018) M. H. J. van den Bosch   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Resting zone of the growth plate houses a unique class of skeletal stem cells

(2018) Koji Mizuhashi et al.   NATURE

Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73+ population and exhibit efficacy after transplantation

(2017) Eriko Grace Suto et al.   Scientific Reports

Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders

(2016) Maurizio Pacifici et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Correlation between Gene Expression and Osteoarthritis Progression in Human

(2016) Leilei Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

(2016) Allyson J. Merrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene expression changes in damaged osteoarthritic cartilage identify a signature of non-chondrogenic and mechanical responses

(2016) S.L. Dunn et al.   OSTEOARTHRITIS AND CARTILAGE

Human mesenchymal stem cells - current trends and future prospective

(2015) Imran Ullah et al.   BIOSCIENCE REPORTS

Estradiol via estrogen receptor beta inhibits chondrogenesis of mouse vertebral growth plate in vitro

(2015) Kefeng Zeng et al.   CHILDS NERVOUS SYSTEM

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

(2015) E. Kozhemyakina et al.   DEVELOPMENT

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis

(2015) Chia-Feng Liu et al.   NUCLEIC ACIDS RESEARCH

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte

(2015) Shinsuke Ohba et al.   Cell Reports

SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

(2014) Pallavi Bhattaram et al.   JOURNAL OF CELL BIOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth

(2014) J. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes

(2012) Peter Dy et al.   DEVELOPMENTAL CELL

The postnatal role of Sox9 in cartilage

(2012) Stephen P Henry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development

(2011) B. Shu et al.   JOURNAL OF CELL SCIENCE

BMP2-activated Erk/MAP Kinase Stabilizes Runx2 by Increasing p300 Levels and Histone Acetyltransferase Activity

(2010) Ji Hae Jun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOX9 determines RUNX2 transactivity by directing intracellular degradation

(2010) Aixin Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors

(2010) Pallavi Bhattaram et al.   Nature Communications

Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage

(2009) Stephen P. Henry et al.   GENESIS

SOX E genes: SOX9 and SOX8 in mammalian testis development

(2009) Francisco Barrionuevo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis

(2008) Eiki Koyama et al.   DEVELOPMENTAL BIOLOGY

The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties

(2008) Peter Dy et al.   NUCLEIC ACIDS RESEARCH

Extracellular matrix and pathogenic mechanisms in osteoarthritis

(2008) Tim Hardingham   Current Rheumatology Reports