Article
Cell Biology
Maochun Wang, Ruiyang Jiang, Guihua Tan, Zizheng Liu, Chen Tang, Rui Wu, Dongquan Shi
Summary: Through transcriptome analysis, we identified transcription factor networks involved in mouse hindlimb morphology establishment. Using embryonic hindlimb transcription profiles from four different developmental stages (E10.5, E11.5, E12.5, and E13.5) obtained from the Gene Expression Omnibus database (GSE30138), we constructed a gene network and defined seven stage-associated modules. Gene ontology enrichment analysis revealed that transcription factors from different modules were enriched in various developmental processes. We further constructed six regulatory networks with key transcription factors, showing their crucial role in hindlimb development.
Review
Immunology
Eva Neugebauer, Aura M. Bastidas-Quintero, Daniel Weidl, Florian Full
Summary: This article reviews the current research progress on how viruses utilize pioneer factors for viral replication and persistence in the host, as well as for the development of viral cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Miaoran Xia, Bingbing Wang, Zihan Wang, Xulong Zhang, Xi Wang
Summary: NK cells are a heterogeneous and plastic population that can directly kill target cells without prior immunization, with their activation controlled by the balance of multiple germline-encoded activating and inhibitory receptors. Epigenetic regulation plays an important role in NK cell-mediated antitumor immunity, and NK cell-based immunotherapy is considered a promising strategy for cancer treatment. By targeting intrinsic epigenetic regulators alone or in combination with other strategies, there is potential to enhance NK cell-mediated antitumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Brittany Vining, Zhenhua Ming, Stefan Bagheri-Fam, Vincent Harley
Summary: Sex determination is a crucial process early in vertebrate embryogenesis, involving a variety of molecular switches and genes. SOX9 plays a central role in male gonadal differentiation, being positively regulated in males and negatively regulated in females. Despite diversity among vertebrates, the protein sequence and function of SOX9 remains highly conserved.
Article
Multidisciplinary Sciences
Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K. Lotz, Hiroshi Asahara
Summary: Osteoarthritis is caused by an imbalance between extracellular matrix synthesis and degradation. Here, the authors show that both strands of microRNA-455, -5p and -3p, target HIF2 alpha and regulate cartilage homeostasis, and show that overexpression of these miRNAs is protective against osteoarthritis in mice.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yihao Yang, Nicholas Gomez, Nicole Infarinato, Rene C. Adam, Megan Sribour, Inwha Baek, Melanie Laurin, Elaine Fuchs
Summary: This study reveals the crucial role of SOX9 in diverting embryonic epidermal stem cells into hair follicle stem cells. By re-activating SOX9 in adult epidermal stem cells, the researchers induce fate switching. They show that SOX9 binds and opens hair follicle enhancers in epidermal stem cells, while recruiting epigenetic factors away from epidermal enhancers, leading to their silencing. This sustained expression of SOX9 subsequently activates oncogenic transcriptional regulators and contributes to the development of cancer.
NATURE CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Reilly A. Sample, Marina F. Nogueira, Robi D. Mitra, Sidharth V. Puram
Summary: Epithelial-to-mesenchymal transition (EMT) is a process in cancer where cells lose their epithelial characteristics and gain mesenchymal phenotypes, driving tumor invasion and metastasis. Recent studies have identified intermediate hybrid E/M states along an epithelial-mesenchymal continuum during EMT. This summary focuses on the involvement of epigenetic regulators, chromatin remodelers, and DNA methylation in hybrid E/M states, while also addressing the challenges of pharmacologically targeting EMT and proposing future research directions.
Review
Cell Biology
Hyeonwoo La, Hyunjin Yoo, Young Bin Park, Nguyen Xuan Thang, Chanhyeok Park, Seonho Yoo, Hyeonji Lee, Youngsok Choi, Hyuk Song, Jeong Tae Do, Kwonho Hong
Summary: The lymphatic system is crucial for maintaining lipid and interstitial fluid homeostasis, as well as regulating immune cell development and functions. Recent studies have shown that epigenetic regulation plays a critical role in embryonic lymphatic endothelial cell (LEC) development and function. Understanding the epigenetic mechanisms involved in lymphatic development and function is important for managing lymphatic disorders.
Article
Biochemistry & Molecular Biology
Harish K. Datta, Marianne K. Kringen, Stephen P. Tuck, Georgia Salpingidou, Ole K. Olstad, Kaare M. Gautvik, Simon J. Cockell, Vigdis T. Gautvik, Michael Prediger, Jun Jie Wu, Mark A. Birch, Sjur Reppe
Summary: Mechanical loading plays a significant role in bone density and architecture. The study demonstrates that the transcriptional factor ZIC1 is strongly associated with genes characteristically associated with bone cells. The findings also suggest a link between mechanical stress and epigenetic control of gene expression, with implications for bone pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
B. He, V. Kram, T. Furusawa, O. Duverger, E. Y. Chu, R. Nanduri, M. Ishikawa, P. Zhang, B. A. Amendt, J. S. Lee, M. Bustin
Summary: The study suggests that HMGN proteins play a role in regulating ameloblast differentiation and enamel mineralization by modulating lineage-specific chromatin accessibility and transcription factor binding to ameloblast regulatory sites. The absence of HMGN proteins in mice leads to faster ameloblast differentiation and increased enamel deposition rate in molars and incisors.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Emilie Bourdonnay, Thomas Henry
Summary: Gasdermins (GSDM) are a family of proteins that play important roles in cell death, immune response, disease susceptibility, and treatment response. The expression of GSDM genes is influenced by various factors and has been associated with diseases such as asthma, inflammatory bowel disease, and cancer.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Plant Sciences
Peng Feng, Xiaohuan Sun, Xiaodong Liu, Yuqiu Li, Qi Sun, Haoran Lu, Minglong Li, Xiaodong Ding, Yingshan Dong
Summary: The study found that the interaction between GsMYST1 and GsSnRK1 can regulate the expression of the COR15B gene through acetylation. Additionally, it was demonstrated that salt stress can activate GsSnRK1, which subsequently phosphorylates GsMYST1 to enhance its acetyltransferase activity, potentially promoting target gene expression through epigenetics.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Marjolein M. J. Caron, Maxime Eveque, Berta Cillero-Pastor, Ron M. A. Heeren, Bas Housmans, Kasper Derks, Andy Cremers, Mandy J. Peffers, Lodewijk W. van Rhijn, Guus van den Akker, Tim J. M. Welting
Summary: Sox9 plays an essential role in regulating ribosome biogenesis factors and ribosomal protein subunits during the early phase of chondrogenic differentiation, affecting translational capacity. Sox9 knockdown leads to decreased translation activity, while overexpression of Sox9 induces reciprocal effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Plant Sciences
Yuming Dong, Sen Li, Haoying Wu, Yiming Gao, Zhongxuan Feng, Xi Zhao, Li Shan, Zhongren Zhang, Huazhong Ren, Xingwang Liu
Summary: Plant growth and development are regulated by complex gene regulatory networks, with epigenetic factors playing a crucial role. Trichomes, specialized appendages arising from epidermal cells, are significant for plant growth and development. Recent studies have implicated epigenetic regulation in trichome development, particularly through microRNA-mediated post-transcriptional regulation.
HORTICULTURE RESEARCH
(2023)
Article
Biology
Weifen Sun, Gangcai Xie, Xi Jiang, Philipp Khaitovich, Dingding Han, Xiling Liu
Summary: By characterizing the genome-wide profiles of histone modifications in the prefrontal cortex of humans, chimpanzees, and rhesus macaques, this study reveals the important regulatory role of histone modifications, especially the HP-H3K27ac mark, in gene expression. Additionally, it shows that histone-modifying enzymes partially contribute to an epigenetic disturbance among primates, specifically for the H3K27ac epigenomic marker. The findings comprehensively elucidate the species-specific gene-histone-enzyme landscape in the prefrontal cortex.
Article
Rheumatology
Marina N. Tariq, Tariq Haqqi, Abdul Haseeb
CLINICAL RHEUMATOLOGY
(2016)
Article
Orthopedics
Abdul Haseeb, Mohammad Yunus Ansari, Tariq M. Haqqi
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Nazir M. Khan, Abdul Haseeb, Mohammad Y. Ansari, Pratap Devarapalli, Sara Haynie, Tariq M. Haqqi
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Meeting Abstract
Orthopedics
N. M. Khan, A. Haseeb, M. Y. Ansari, T. M. Haqqi
OSTEOARTHRITIS AND CARTILAGE
(2017)
Article
Chemistry, Medicinal
Abdul Haseeb, Nazir M. Khan, Omer S. Ashruf, Tariq M. Haqqi
PHYTOTHERAPY RESEARCH
(2017)
Article
Multidisciplinary Sciences
Nazir M. Khan, Abdul Haseeb, Mohammad Y. Ansari, Tariq M. Haqqi
SCIENTIFIC REPORTS
(2017)
Editorial Material
Biotechnology & Applied Microbiology
Sadiq Umar, Abdul M. Tyagi, Anil K. Singh, Abdul Haseeb
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Multidisciplinary Sciences
Abdul Haseeb, Mohammad Shahidul Makki, Nazir M. Khan, Imran Ahmad, Tariq M. Haqqi
SCIENTIFIC REPORTS
(2017)
Article
Genetics & Heredity
Ash Zawerton, Baojin Yao, J. Paige Yeager, Tommaso Pippucci, Abdul Haseeb, Joshua D. Smith, Lisa Wischmann, Susanne J. Kuehl, John C. S. Dean, Daniela T. Pilz, Susan E. Holder, Alisdair McNeill, Claudio Graziano, Veronique Lefebvre
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Multidisciplinary Sciences
Nazir M. Khan, Abdul Haseeb, Mohammad Y. Ansari, Pratap Devarapalli, Sara Haynie, Tariq M. Haqqi
Meeting Abstract
Rheumatology
Marina N. Magre, Abdul Haseeb, Tariq M. Haqqi
ARTHRITIS & RHEUMATOLOGY
(2016)
Meeting Abstract
Rheumatology
Mohammad N. Khan, Abdul Haseeb, Sara Haynie, Tariq M. Haqqi
ARTHRITIS & RHEUMATOLOGY
(2016)
Meeting Abstract
Rheumatology
Abdul Haseeb, Mohammad Shahidul Makki, Mohammad Ansari, Helen Piontkivska, Tariq M. Haqqi
ARTHRITIS & RHEUMATOLOGY
(2016)
Meeting Abstract
Rheumatology
Abdul Haseeb, Mohammad Ansari, Tariq Haqqi
ARTHRITIS & RHEUMATOLOGY
(2015)