Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer

9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non‐small‐cell lung cancer

(2019) Rangru Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells

(2019) Likun Gao et al.   Cell Death & Disease

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Oridonin Sensitizes Cisplatin-Induced Apoptosis via AMPK/Akt/mTOR-Dependent Autophagosome Accumulation in A549 Cells

(2019) Huahong Yang et al.   Frontiers in Oncology

EGFR-mediated autophagy in tumourigenesis and therapeutic resistance

(2019) Min Wu et al.   CANCER LETTERS

Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-α

(2019) Huimin Deng et al.   CYTOKINE

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

Daphnetin alleviates lipopolysaccharide/ d -galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-κB, and the induction of autophagy

(2018) Hongming Lv et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

7,8-Dihydroxycoumarin exerts antitumor potential on DMBA-induced mammary carcinogenesis by inhibiting ERα, PR, EGFR, and IGF1R: involvement of MAPK1/2-JNK1/2-Akt pathway

(2018) Abhishek Kumar et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy

(2018) Wei Liu et al.   Cell Death & Disease

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways

(2016) Abhishek Kumar et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

(2015) Prashanta Kumar Panda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Paradoxical action of reactive oxygen species in creation and therapy of cancer

(2014) Sina Kardeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel therapies, including enzastaurin, in the treatment of ovarian cancer

(2014) Ignace Vergote   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

The radiosensitizing effect of Paeonol on lung adenocarcinoma by augmentation of radiation-induced apoptosis and inhibition of the PI3K/Akt pathway

(2013) Yu Lei et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

(2013) Shu Bian et al.   PLoS One

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

(2012) I Ben-Sahra et al.   CELL DEATH AND DIFFERENTIATION

Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species

(2012) Shin-Hyung Park et al.   TOXICOLOGY LETTERS

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

(2010) Ljubica Vucicevic et al.   Autophagy

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence

(2008) Laura J. Havrilesky et al.   GYNECOLOGIC ONCOLOGY