Article
Plant Sciences
Xiaoye Fan, Min Xie, Feijie Zhao, Jiajia Li, Changqing Fan, Hao Zheng, Zhentong Wei, Xinxin Ci, Songling Zhang
Summary: The study demonstrates that Daph induces ROS-dependent apoptosis in ovarian cancer cells and triggers cytoprotective autophagy through the modulation of the AMPK/Akt/mTOR pathway. Combination therapy of Daph and an autophagy inhibitor shows synergistic effects on inhibiting cell viability and promoting apoptosis in ovarian cancer cells, suggesting a potential therapeutic strategy.
Article
Biochemistry & Molecular Biology
Zhongnan Wu, Wen Li, Qing Tang, Laiqiang Huang, Zhaochun Zhan, Yaolan Li, Guocai Wang, Xiaoyong Dai, Yubo Zhang
Summary: PEG, derived from fungi, can inhibit the growth of NSCLC cells by suppressing cell cycle and MET pathway. The study suggests that PEG has the potential to be developed as a drug candidate for treating NSCLC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ching-Yeh Lin, Ya-Hui Chen, Ying-Chih Huang
Summary: The study evaluated the mechanisms of hesperetin in leukemia cells and found that hesperetin can promote cell death in U937 cells through inducing slight apoptosis, cell cycle arrest, and autophagy. This suggests that hesperetin may serve as an adjuvant to antileukemia therapy and can be combined with other chemotherapeutic drugs to reduce chemoresistance and side effects.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Yu Wang, Runhong Mei, Shimin Hao, Peng Luo, Penghao Wang, Yaser Almatari, Lei Guo, Lan Guo
Summary: The study revealed that up-regulation of SIRT1 induced by 17 beta-E2 promoted autophagy and inhibited apoptosis in osteoblasts through the AMPK-mTOR and FOXO3a pathways. This suggests that SIRT1 may be a valuable target for osteoporosis treatment, providing new insights into its role in protecting bone cells.
Article
Cell Biology
Xiao-Zhong Liao, Ying Gao, Hong-Wei Zhao, Mi Zhou, Dan-Lei Chen, Lan-Ting Tao, Wei Guo, Ling-Ling Sun, Chu-Ying Gu, Han-Rui Chen, Zhi-Wei Xiao, Jia-Xing Zhang, Mei-Fang He, Li-Zhu Lin
Summary: The study demonstrates that the combination of cordycepin (Cor) and cisplatin (DDP) has a synergistic effect on inhibiting proliferation and promoting apoptosis of non-small cell lung cancer (NSCLC) cells. The synergistic actions are associated with the activation of AMPK and inhibition of the AKT pathway. This combination therapy may offer a new therapeutic option for DDP-resistant NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ming Xin, Qi Gao, Xindong Xiang, Juanjuan Xu, Yuhan Jiao, Xuan Li, Xianzhen Zhang, Xiuqin Jia
Summary: The study found that methylseleninic acid (MSA) effectively inhibits the proliferation of lung adenocarcinoma cells and counteracts cisplatin resistance by promoting apoptosis. The mitochondrial damage caused by MSA treatment can be degraded through the induction of autophagy, providing self-protection for tumor cells. Mechanistically, MSA inhibits cell proliferation, promotes apoptosis, and induces autophagy in lung adenocarcinoma cells by inhibiting the Akt/mTOR pathway. Combination with autophagy inhibitors enhances the anti-tumor effect of MSA on cisplatin-resistant lung adenocarcinoma cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Mingfei Wu, Yan Cong, Kailu Wang, Haiyang Yu, Xuan Zhang, Mingyue Ma, Zhiwen Duan, Xiucong Pei
Summary: This study investigates the effects of BPA on macrophages and its mechanism of action. The results show that BPA decreases cell viability and disrupts macrophage function by inhibiting autophagy and inducing apoptosis. Activation of autophagy and inhibition of apoptosis can ameliorate the damage caused by BPA on macrophages.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Sheng Zhang, Xueping Wei, Haijin Zhang, Youping Wu, Junsong Jing, Rongrong Huang, Ting Zhou, Jingjin Hu, Yueguo Wu, Yuanyuan Li, Zhenqiang You
Summary: This study establishes a model of DOX-induced dilated cardiomyopathy and reveals the role of mTOR in DOX-induced cardiomyocyte apoptosis and autophagy. Rapamycin and metformin protect cardiomyocytes from DOX-induced damage by regulating the AMPK/mTOR axis, maintaining energy metabolism balance, reducing oxidative stress, and decreasing cardiomyocyte apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Jiaqiao Li, Yameng Fan, Yan Zhang, Yamei Liu, Yan Yu, Mao Ma
Summary: Resveratrol induces autophagy and apoptosis in non-small-cell lung cancer A549 cells, and this process is regulated by the NGFR-AMPK-mTOR signaling pathway.
Article
Fisheries
Xin Chen, Jun Ma, Hao Chen
Summary: This study found that deoxynivalenol (DON) can induce cytotoxicity, oxidative stress, and apoptosis in grass carp liver cells (L8824) through autophagy. Furthermore, oxidative stress inhibitor attenuates DON-induced autophagy, while autophagy inhibitor enhances ROS production.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Juan Wang, Guoxiang Liu, Xiaojuan Li, Mengjie Huangfu, Yisa Liu, Xumei Li, Dan Yu, Luwei Zhou, Xu Chen
Summary: Curcumol induces autophagy through the AMPK/mTOR pathway in NPC cells, and inhibiting autophagy can increase proliferation while attenuating apoptosis and autophagy. Combining curcumol with the autophagy agonist rapamycin and apoptosis inducer MG132 synergizes the apoptotic and autophagic effect of curcumol, suggesting a potential new therapeutic strategy for NPC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Wenxian Zhou, Yifeng Shi, Hui Wang, Caiyu Yu, Huanqing Zhu, Aimin Wu
Summary: The study demonstrated that Sin can protect against OA by promoting chondrocyte autophagy, suggesting its potential therapeutic value in OA treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Qing-song Chen, Ai Shen, Jiang-wen Dai, Ting-ting Li, Wei-feng Huang, Kun Shi, Yi Deng, Long Pan, Xu-fu Wei, Zhong-jun Wu
Summary: The study revealed that IL37 can alleviate hepatic ischemia reperfusion injury by modulating autophagy and apoptosis, potentially through the regulation of the AMPK/mTOR/ULK1 signaling complex.
Article
Pathology
Li Jia, Yan Chen, Fukun Chen, Juan Lv, Yanling Li, Fei Hou, Zhixian Yang, Zhiyong Deng
Summary: The study demonstrated that saRNA-mediated NIS expression plays a critical role in increasing iodide uptake through the AMPK/mTOR pathway in thyroid cancer. NIS-mediated autophagy regulates cell proliferation, apoptosis, and autophagy, ultimately affecting iodide uptake.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Qin Ye, Li Zhou, Ping Jin, Lei Li, Shuwen Zheng, Zhao Huang, Jiayang Liu, Siyuan Qin, Hao Liu, Bingwen Zou, Ke Xie
Summary: The study showed that GYZ can suppress NSCLC by inducing apoptosis through triggering ROS and inhibiting the autophagic pathway in NSCLC cells, which has a cytoprotective effect. Co-administration with an autophagy inhibitor enhances the effectiveness of GYZ, and GYZ acts synergistically with paclitaxel in suppressing NSCLC growth.
FRONTIERS IN PHARMACOLOGY
(2021)