9za plays cytotoxic and proapoptotic roles and induces cytoprotective autophagy through the PDK1/Akt/mTOR axis in non‐small‐cell lung cancer

PDK1: At the crossroad of cancer signaling pathways

(2018) Paolo Armando Gagliardi et al.   SEMINARS IN CANCER BIOLOGY

Inhibiting ROS-NF-κB-dependent autophagy enhanced brazilin-induced apoptosis in head and neck squamous cell carcinoma

(2017) Zhi-Jing He et al.   FOOD AND CHEMICAL TOXICOLOGY

M 4 IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway

(2017) Ying Peng et al.   LIFE SCIENCES

Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells

(2016) YUNFENG FU et al.   Molecular Medicine Reports

Classification and Pathology of Lung Cancer

(2016) Min Zheng   Surgical Oncology Clinics of North America

Nonylphenol induced apoptosis and autophagy involving the Akt/mTOR pathway in prepubertal Sprague-Dawley male rats in vivo and in vitro

(2016) Wenting Huang et al.   TOXICOLOGY

Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma

(2016) Mridul Roy et al.   Theranostics

Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

(2014) Andrew Poklepovic et al.   Autophagy

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Cytotoxic Autophagy in Cancer Therapy

(2014) Khushboo Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of PDK1 associates with poor prognosis in esophageal squamous cell carcinoma with facilitating tumorigenicity in vitro

(2014) Zhonglu Yang et al.   MEDICAL ONCOLOGY

The role of autophagy induced by pemetrexed in lung adenocarcinoma cells

(2014) JI-HYE PARK et al.   ONCOLOGY REPORTS

An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy

(2014) Mickaël Michaud et al.   OncoImmunology

Targeting Apoptosis Pathways for New Cancer Therapeutics

(2013) Longchuan Bai et al.   Annual Review of Medicine

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts

(2013) J. Zabkiewicz et al.   HAEMATOLOGICA

The Autophagy Inhibitor Chloroquine Overcomes the Innate Resistance of Wild-Type EGFR Non-Small-Cell Lung Cancer Cells to Erlotinib

(2013) Yiyu Zou et al.   Journal of Thoracic Oncology

Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf V600E ::Pten –/– melanoma

(2013) M Scortegagna et al.   ONCOGENE

Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway

(2013) Q Deng et al.   Cell Death & Disease

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Targeted Small-Molecule Inhibitors of Protein Kinase B as Anticancer Agents

(2012) Ian Collins   Anti-Cancer Agents in Medicinal Chemistry

PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations

(2012) Filip Janku et al.   JOURNAL OF CLINICAL ONCOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Advances in the Development of Cancer Therapeutics Directed against the RAS-Mitogen-Activated Protein Kinase Pathway

(2008) J. S. Sebolt-Leopold   CLINICAL CANCER RESEARCH

A Japanese Lung Cancer Registry Study: Prognosis of 13,010 Resected Lung Cancers

(2008) Hisao Asamura et al.   Journal of Thoracic Oncology

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE