Article
Critical Care Medicine
Booker T. Davis, Zhangying Chen, Mecca B. A. R. Islam, Madeline E. Timken, Daniele Procissi, Steven J. Schwulst
Summary: Traumatic brain injury (TBI) can lead to dysbiosis of the gut microbiota, while fecal microbiota transfer (FMT) can restore the microbial community structure. In a mouse study, TBI mice treated with FMT showed improved neurocognitive and anatomical deficits. These findings suggest that restoring pre-injury gut microbial community structure may be an effective therapeutic intervention after TBI.
Article
Immunology
Jianjun Yu, Jianhong Meng, Zhengwei Qin, Yuan Yu, Yingxin Liang, Yanjun Wang, Dongmei Min
Summary: This study reveals significant differences in diversity, abundance, and functional composition of gut microbiota between PD patients and healthy individuals. Dysbiosis of gut microbiota may affect the occurrence and development of PD by regulating the NAD(+) metabolism pathway. FMT or overexpression of NMNAT2 alleviates neurobehavioral deficits and oxidative stress in 6-OHDA-lesioned rats.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biotechnology & Applied Microbiology
Ziaur Rahman, Nagesh A. Bhale, Amol G. Dikundwar, Manoj P. Dandekar
Summary: Recent studies have highlighted the importance of gut microbiota in the neuropathology of post-stroke brain injury and recovery. Ingestion of prebiotics/probiotics has positive effects on brain injury, neuroinflammation, gut dysbiosis, and intestinal integrity. However, more research is needed to understand the disease-specific preference of different prebiotics/probiotics and their underlying mechanisms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Review
Food Science & Technology
Yuhan Zhao, Mengjie Li, Yanan Wang, Ruixuan Geng, Jingjing Fang, Qing Liu, Seong-Gook Kang, Wei Cai Zeng, Kunlun Huang, Tao Tong
Summary: This article discusses the relationship between diet and gut microbiota, the mechanism linking diabetes and gut dysbiosis, and the effects of dietary components on diabetes from the perspective of modulating gut microbiota. It provides compelling evidence that targeting gut microbiota through dietary interventions is a promising strategy for the clinical management of diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Clinical Neurology
Carlo Romano Settanni, Gianluca Ianiro, Stefano Bibbo, Giovanni Cammarota, Antonio Gasbarrini
Summary: This article discusses the role of gut microbiota in maintaining central and peripheral functions as well as mental health, and the association between dysbiosis and psychiatric disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Neurosciences
Hanif Ullah, Safia Arbab, Yali Tian, Chang-qing Liu, Yuwen Chen, Li Qijie, Muhammad Inayat Ullah Khan, Inam Ul Hassan, Ka Li
Summary: The gut microbiota has a significant impact on the host's physiology and pathology, communicating with different organs through hormone synthesis and regulation of body activity. Dysbiosis in the gut microbiota leads to gastrointestinal disorders that affect host physiology through abnormal microbial metabolites. This dysbiosis alters the bidirectional relationship between the central nervous system and gut microbiota, contributing to the pathogenesis of neurodevelopmental and neurological disorders. Increasing evidence suggests that gut microbes may play a role in the progression of neurological disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and autism spectrum disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Katarzyna Socala, Urszula Doboszewska, Aleksandra Szopa, Anna Serefko, Marcin Wlodarczyk, Anna Zielinska, Ewa Poleszak, Jakub Fichna, Piotr Wlaz
Summary: Emerging evidence suggests that gut microbiota play a crucial role in the bidirectional communication between the gut and brain, influencing neural development, neurotransmission, and behavior. Studies have explored the role of microbiota in various neuropsychiatric and neurological disorders, including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. This review discusses data from both preclinical experiments and clinical reports, highlighting the effects of probiotic, prebiotic, or antibiotic treatments, as well as fecal microbiota transplantation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Sona Ciernikova, Aneta Sevcikova, Lubos Drgona, Michal Mego
Summary: Treatment resistance and adverse effects are important issues in cancer patient management. The use of microbiome in oncology is showing promising results. Favorable bacterial species and gut diversity are associated with increased treatment efficacy, while alterations in gut microbiome contribute to intestinal dysbiosis and treatment-induced toxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Microbiology
Liang Hong, Sang-Mok Lee, Whee-Soo Kim, Yun-Jaie Choi, Seo-Ho Oh, Yu-Ling Li, Seung-Hoon Choi, Dong Hyen Chung, Eunkyoung Jung, Sang-Kee Kang, Chong-Su Cho
Summary: The study demonstrated that nanoprebiotics enhance the antimicrobial activity of probiotics, and the combination of nanoprebiotics and probiotics has a better therapeutic effect in vivo than probiotics alone, restoring gut dysbiosis, suppressing pathogenic infection, and increasing microbial diversity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Review
Microbiology
Xianzhuo Zhang, Xufei Luo, Liang Tian, Ping Yue, Mengyao Li, Kefeng Liu, Daoming Zhu, Chongfei Huang, Qianling Shi, Liping Yang, Zhili Xia, Jinyu Zhao, Zelong Ma, Jianlong Li, Joseph W. Leung, Yanyan Lin, Jinqiu Yuan, Wenbo Meng, Xun Li, Yaolong Chen
Summary: This study summarized the associations between gut microbiome dysbiosis and various diseases, and conducted an umbrella review to determine the efficacy and safety of fecal microbiota transplantation (FMT) in treating these diseases. The research found that FMT was effective for recurrent Clostridium difficile infection (rCDI) with a high cure rate, and had moderate to high quality evidence for ulcerative colitis and Crohn's disease, but low to very low quality evidence for other diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Angelica Varesi, Elisa Pierella, Marcello Romeo, Gaia Bavestrello Piccini, Claudia Alfano, Geir Bjorklund, Abigail Oppong, Giovanni Ricevuti, Ciro Esposito, Salvatore Chirumbolo, Alessia Pascale
Summary: The dysregulation of gut microbiota is implicated in various diseases, including Alzheimer's Disease (AD). This article reviews the role of gut microbiota in brain health and disease and presents evidence for its dysregulation in AD patients. It discusses the potential of using dysbiosis as a diagnostic tool and explores the therapeutic interventions using prebiotics, probiotics, fecal microbiota transplantation, and diets in AD.
Review
Biochemistry & Molecular Biology
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Foroogh Fahmideh, Elisa Pierella, Marcello Romeo, Giovanni Ricevuti, Marchesi Nicoletta, Salvatore Chirumbolo, Alessia Pascale
Summary: The bidirectional interaction between the gut microbiota and the Central Nervous System has a significant impact on brain function and the development of neurodegenerative diseases, such as Parkinson's disease. Several studies have explored the role of dysbiosis and intestinal permeability in the onset and progression of Parkinson's disease, but the therapeutic applications of GM modifying approaches need further elucidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yingli Jing, Yan Yu, Fan Bai, Limiao Wang, Degang Yang, Chao Zhang, Chuan Qin, Mingliang Yang, Dong Zhang, Yanbing Zhu, Jianjun Li, Zhiguo Chen
Summary: Fecal microbiota transplantation (FMT) from healthy uninjured mice into SCI mice was found to improve locomotor and GI functions through promoting neuronal axonal regeneration, enhancing intestinal barrier integrity and modifying gut microbiome composition. Additionally, FMT increased levels of short-chain fatty acids (SCFAs) in feces and downregulated inflammatory signaling pathways in the spinal cord and gut of SCI mice. These findings suggest that FMT may have a neuroprotective effect on SCI.
Article
Neurosciences
L. Jiang, J. Zhong, X. Dou, C. Cheng, Z. Huang, X. Sun
Article
Clinical Neurology
Zhipeng Teng, Li Jiang, Qin Hu, Yue He, Zhenni Guo, Yue Wu, Zhijian Huang, Fang Cao, Chongjie Cheng, Xiaochuan Sun, Zongduo Guo
Article
Neurosciences
Jianjun Zhong, Li Jiang, Chongjie Cheng, Zhijian Huang, Hongrong Zhang, Han Liu, Junchi He, Fang Cao, Jianhua Peng, Yong Jiang, Xiaochuan Sun
Article
Biochemistry & Molecular Biology
Zhijian Huang, Chongjie Cheng, Li Jiang, Zhanyang Yu, Fang Cao, Jianjun Zhong, Zongduo Guo, Xiaochuan Sun
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Neurosciences
Jianjun Zhong, Chongjie Cheng, Han Liu, Zhijian Huang, Yue Wu, Zhipeng Teng, Junchi He, Hongrong Zhang, Jinchuan Wu, Fang Cao, Li Jiang, Xiaochuan Sun
Article
Multidisciplinary Sciences
Zhipeng Teng, Zongduo Guo, Jianjun Zhong, Chongjie Cheng, Zhijian Huang, Yue Wu, Shuang Tang, Chao Luo, Xing Peng, Haitao Wu, Xiaochuan Sun, Li Jiang
SCIENTIFIC REPORTS
(2017)
Article
Medicine, General & Internal
Han Liu, Junchi He, Jianjun Zhong, Hongrong Zhang, Zhaosi Zhang, Liu Liu, Zhijian Huang, Yue Wu, Li Jiang, Zongduo Guo, Rui Xu, Weina Chai, Gang Huo, Xiaochuan Sun, Chongjie Cheng
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2018)
Article
Neurosciences
Junchi He, Han Liu, Jianjun Zhong, Zongduo Guo, Jingchuan Wu, Hongrong Zhang, Zhijian Huang, Li Jiang, Hui Li, Zhaosi Zhang, Liu Liu, Yue Wu, Lingjun Qi, Xiaochuan Sun, Chongjie Cheng
NEUROBIOLOGY OF DISEASE
(2018)
Article
Neurosciences
Zhihao Chen, Hong Wang, Jianjun Zhong, Junqing Yang, Rami Darwazeh, Xiaocui Tian, Zhijian Huang, Li Jiang, Chongjie Cheng, Yue Wu, Zongduo Guo, Xiaochuan Sun
EXPERIMENTAL NEUROLOGY
(2019)
Article
Cell Biology
Yue Wu, Jinwei Pang, Jianhua Peng, Fang Cao, Zongduo Guo, Li Jiang, Zhipeng Teng, Zhijian Huang, Chongjie Cheng, Yong Jiang, Xiaochuan Sun
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Cell Biology
Wei Tang, Weina Chai, Donglin Du, Yongzhi Xia, Yifan Wu, Li Jiang, Chongjie Cheng, Zongduo Guo, Xiaochuan Sun, Zhijian Huang, Jianjun Zhong
Summary: This study found that lncRNA-AK046375 enhances MT2 expression by sequestering miR-491-5p, ameliorating oxidative-induced cell injury, and promoting the recovery of motor, learning, and memory functions post-TBI.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Clinical Neurology
Yue Wu, Qiuguang He, Yuling Wei, Ji Zhu, Zhaohui He, Xiaodong Zhang, Zongduo Guo, Rui Xu, Chongjie Cheng, Zhijian Huang, Xiaochuan Sun
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2019)
Article
Immunology
Jianjun Zhong, Li Jiang, Zhijian Huang, Hongrong Zhang, Chongjie Cheng, Han Liu, Junchi He, Jingchuan Wu, Rami Darwazeh, Yue Wu, Xiaochuan Sun
BRAIN BEHAVIOR AND IMMUNITY
(2017)