Article
Neurosciences
Li Wang, Quan Lei, Shuai Zhao, WenJuan Xu, Wei Dong, JiHua Ran, QingHai Shi, JianFeng Fu
Summary: Ginkgolide B shows protective effects in neuronal cells subjected to hypoxia by regulating neuronal Ca2+ homeostasis and suppressing increases in cytoplasmic Ca2+ levels. This compound can also inhibit actions of hypoxia on spontaneous discharge frequency, action potential frequency, and calcium current magnitude, suggesting its potential as a neuroprotective agent against hypoxic injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Jennifer N. Belding, Robyn M. Englert, Shannon Fitzmaurice, Jourdan R. Jackson, Hannah G. Koenig, Michael A. Hunter, Cynthia J. Thomsen, Uade Olaghere da Silva
Summary: This scoping review provides a comprehensive overview of the literature on blast exposure, with a focus on low-level blast (LLB) exposure. The findings suggest that LLB exposure may have detrimental effects on the health of both animals and humans, but the results are mixed and more research is needed. Collaboration across disciplines, larger sample sizes, and standardization of terminology, exposures, and outcomes would benefit future research in this area.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell Biology
Sung-Min Hwang, Ji Yeon Lee, Chul-Kyu Park, Yong Ho Kim
Summary: Neurodegenerative diseases (NDs) primarily affect neurons and glial cells in the brain, with risk factors and pathophysiological mechanisms not fully understood. Homeostasis of intracellular Ca2+ concentration and pH is crucial for cell function, with TRP channels and PMCA playing vital roles in modulating ionic homeostasis. Dysfunctions of TRP channels and PMCA disrupt neuronal homeostasis under pathological conditions, resulting in various NDs. This review highlights their potential as novel targets for treating NDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Rida Rehman, Michael Miller, Sruthi Sankari Krishnamurthy, Jacob Kjell, Lobna Elsayed, Stefanie M. Hauck, Florian Olde Heuvel, Alison Conquest, Akila Chandrasekar, Albert Ludolph, Tobias Boeckers, Medhanie A. Mulaw, Magdalena Goetz, Maria Cristina Morganti-Kossmann, Aya Takeoka, Francesco Roselli
Summary: This study investigates the role of tyrosine-kinase signaling in traumatic brain injury (TBI) using array phosphoproteomics. The findings reveal that Met/HGFR serves as a modulator of early neuroinflammation in TBI and inhibition of Met/HGFR can improve neuronal survival and motor recovery.
Article
Toxicology
Xiaoqiu Zhu, Yiyi Yao, Mingyan Guo, Jin Li, Pengfeng Yang, Hui Xu, Daowei Lin
Summary: Sevoflurane was found to increase intracellular Ca2+ concentration, leading to neuronal death and mitochondrial injury, ultimately inducing neuroapoptosis.
TOXICOLOGY LETTERS
(2021)
Review
Medicine, General & Internal
Mariyam Humayun, Lavienraj Premraj, Vishank Shah, Sung-Min Cho
Summary: Acute respiratory distress syndrome (ARDS) is commonly seen in patients with acute brain injury (ABI), and lung injury in ABI occurs secondary to catecholamine surge and neuro-inflammatory processes. Lung protective ventilation strategies that benefit ARDS patients may interfere with neurological recovery in ABI patients. Hypoxia leads to poor outcomes in ABI, hence a lower PO2 target may not be the best practice in patients with concomitant ARDS and severe ABI.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Rong Fu, Xiaowan Jiang, Yuyan Yang, Chunxia Wang, Yun Zhang, Yi Zhu, Huimin Zhang
Summary: This study investigates the effects of structural damage on autophagy in C. elegans. The researchers found that damage to the basal extracellular matrix or underlying muscle cells promotes autophagy activation in the epidermis, while damage to the apical side inhibits autophagy. Furthermore, elevated autophagy in the epidermis is detrimental to cell survival. These findings provide insights into the regulation of autophagy by structural and mechanical properties of cells.
Review
Neurosciences
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Summary: This literature review investigated whether a single moderate to severe head injury leads to long-term development of tauopathy. The results of most human and animal studies suggest that a single moderate to severe head injury is associated with greater chronic development of tauopathy, but caution is needed due to limitations in the studies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Physiology
Jiqiang Song, Yanping Yu, Zhichao Yan, Shan Xiao, Xianxin Zhao, Fang Wang, Qi Fang, Gongyin Ye
Summary: This study investigated the characteristics and functions of CLIC in Hi-5 cells, and found that the TnCLIC protein is essential for the survival of Hi-5 cells and has a lethal effect when knocked down in different insect cell lines. It was also discovered that the knockdown of TnCLIC leads to an increase in intracellular calcium ion levels. These results provide insights into the crucial role of insect CLIC in cell survival and lay the foundation for understanding the cell death mechanism.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Joshua Sandry, Ekaterina Dobryakova
Summary: This study evaluated the importance of subcortical gray matter atrophy in differentiating chronic moderate-severe TBI from non-TBI participants, finding extensive atrophy across nearly all brain regions for chronic TBI individuals. The data supported an accelerated aging hypothesis in chronic moderate-severe TBI coinciding with a similar neuropathological profile found in neurodegenerative diseases that was observed in the study.
Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Xiancheng Yu, Thuy-Tien Nguyen, Tianchi Wu, Mazdak Ghajari
Summary: This study investigated the difference in cerebrospinal fluid (CSF) cavitation between blasts and impacts, and proposed a mechanism explaining the lower negative pressure produced by blasts in the contrecoup CSF region. Experimental results and computational modeling validated this mechanism. These findings have significant implications for the prevention and diagnosis of blast-induced traumatic brain injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Physiology
David Eisner, Erwin Neher, Holger Taschenberger, Godfrey Smith
Summary: Calcium signaling is crucial for physiology. The chemistry of interactions between calcium and buffers determines the effects of calcium buffering on normal physiology, as well as the consequences of changes in disease.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Clinical Neurology
Chengcheng Zhao, Yuefei Deng, Yi He, Xianjian Huang, Chuanfang Wang, Weiping Li
Summary: Activated microglia can inhibit neurite outgrowth and synapse recovery following traumatic brain injury through exosome-mediated mechanisms. Exosomes derived from stretch-injured microglia were shown to be absorbed by neurons and decrease protein levels associated with neurite outgrowth and synapse recovery, ultimately impairing motor coordination in mice after injury. Overexpression of miR-5121 in these exosomes partly reversed the suppression of neurite outgrowth and synapse recovery, indicating a potential therapeutic target for improving outcomes following TBI.
Article
Genetics & Heredity
Cesar Fernandez-de-las-Penas, Lars Arendt-Nielsen, Gema Diaz-Gil, Francisco Gomez-Esquer, Antonio Gil-Crujera, Stella M. Gomez-Sanchez, Silvia Ambite-Quesada, Maria A. Palomar-Gallego, Oscar J. Pellicer-Valero, Rocco Giordano
Summary: The study aimed to investigate the association between the Apolipoprotein E (ApoE) gene and long COVID symptoms. The results showed no significant relationship between different genotypes of the ApoE gene (ApoE ε2, ApoE ε3, ApoE ε4) and the presence of long COVID symptoms.
Article
Neurosciences
Jianhua Peng, Yue Wu, Jinwei Pang, Xiaochuan Sun, Ligang Chen, Yue Chen, Jiping Tang, John H. Zhang, Yong Jiang
Article
Cell & Tissue Engineering
Cheng Yin, Zong-duo Guo, Zong-ze He, Zhen-yu Wang, Xiao-chuan Sung
CELL TRANSPLANTATION
(2019)
Article
Clinical Neurology
Jianfeng Zheng, Rui Xu, Zongduo Guo, Xiaochuan Sun
NEUROLOGICAL RESEARCH
(2019)
Article
Neurosciences
Zhihao Chen, Hong Wang, Jianjun Zhong, Junqing Yang, Rami Darwazeh, Xiaocui Tian, Zhijian Huang, Li Jiang, Chongjie Cheng, Yue Wu, Zongduo Guo, Xiaochuan Sun
EXPERIMENTAL NEUROLOGY
(2019)
Article
Neurosciences
Liu Liu, Ping Zhang, Zhaosi Zhang, Qin Hu, Junchi He, Han Liu, Jun Zhao, Yidan Liang, Zhaohui He, Xinghua Li, Xiaochuan Sun, Zongduo Guo
Article
Clinical Neurology
Jianfeng Zheng, Zongduo Guo, Rui Xu, Zhaohui He, Xiaochuan Sun
WORLD NEUROSURGERY
(2019)
Article
Neurosciences
Liang Wang, Zhaosi Zhang, Luodan Liang, Yue Wu, Jianjun Zhong, Xiaochuan Sun
NEUROSCIENCE LETTERS
(2019)
Letter
Clinical Neurology
Rami Darwazeh, Mazhar Darwazeh, Ibrahim Sbeih, Chao You, Yi Yan, Xiaochuan Sun
WORLD NEUROSURGERY
(2019)
Article
Cell Biology
Donglin Du, Wei Tang, Chao Zhou, Xiaochuan Sun, Zhengqiang Wei, Jianjun Zhong, Zhijian Huang
Summary: The study demonstrates that traumatic brain injury alters gut microbiota, while fecal microbiota transplantation can restore dysbiosis and alleviate neurological deficits possibly through the TMA-TMAO-MsrA signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Neurosciences
Zhimin Wu, Yanfeng Xie, Senjie Xiong, Jie Li, Xiaochuan Sun, Quanhong Shi, Wei Dan, Li Jiang
Summary: The Venous Occlusion Image Score (VOIS) is an effective method for diagnosing and assessing the prognosis of cerebral venous sinus thrombosis (CVST), and plays an important role in guiding treatment and predicting outcomes in patients with CVST.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Cell Biology
Wei Tang, Weina Chai, Donglin Du, Yongzhi Xia, Yifan Wu, Li Jiang, Chongjie Cheng, Zongduo Guo, Xiaochuan Sun, Zhijian Huang, Jianjun Zhong
Summary: This study found that lncRNA-AK046375 enhances MT2 expression by sequestering miR-491-5p, ameliorating oxidative-induced cell injury, and promoting the recovery of motor, learning, and memory functions post-TBI.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Neurosciences
Bocheng Yang, Xiaochuan Sun, Quanhong Shi, Wei Dan, Yan Zhan, Dinghao Zheng, Yulong Xia, Yanfeng Xie, Li Jiang
Summary: This study aimed to design a model for predicting the early prognosis of traumatic brain injury (TBI) patients using parameters that can be quickly obtained in emergency conditions. The results showed that age, Glasgow coma scale score, Apolipoprotein E genotype, damage area, serum C-reactive protein and interleukin-8 levels, and Marshall computed tomography score were associated with the early prognosis of TBI patients. The prediction models based on these parameters provided a reliable and rapid method for evaluating and predicting the early prognosis of TBI patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Xun Lin, Qilin Li, Xiaochuan Sun, Quanhong Shi, Wei Dan, Yan Zhan, Bo Deng, Yulong Xia, Yanfeng Xie, Li Jiang
Summary: This study examined the effects of the APOE gene on cerebral oxygen saturation and perfusion in early stages of traumatic brain injury (TBI). The results showed that APOEe4 carriers had significantly lower oxygen saturation and longer MTT compared to non-carriers. There was a negative correlation between oxygen saturation and MTT. APOE e4, hypoxia, MTT >5.75 s, Marshall CT class, and GCS were identified as independent risk factors for poor prognosis in TBI patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Yue Wu, Qiuguang He, Yuling Wei, Ji Zhu, Zhaohui He, Xiaodong Zhang, Zongduo Guo, Rui Xu, Chongjie Cheng, Zhijian Huang, Xiaochuan Sun
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2019)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
