Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy

(2020) Gaocai Li et al.   Cell Death & Disease

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

(2020) Hui Che et al.   eLife

Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function

(2020) Guang-Zhi Zhang et al.   CLINICA CHIMICA ACTA

Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

(2020) Run‐Ze Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

(2019) Guangya Zhang et al.   Cell Death & Disease

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells

(2019) Rongjin Luo et al.   LIFE SCIENCES

Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice

(2019) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

(2019) Sidong Yang et al.   AGEING RESEARCH REVIEWS

Antioxidant functionalized polymer capsules to prevent oxidative stress

(2018) Aitor Larrañaga et al.   Acta Biomaterialia

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration

(2018) Yu Song et al.   Redox Biology

Treatment of Low Back Pain

(2017) Hannah C. Wenger et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Non-specific low back pain

(2017) Chris Maher et al.   LANCET

ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration

(2017) Chencheng Feng et al.   Oxidative Medicine and Cellular Longevity

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

(2017) Anthony S. Grillo et al.   SCIENCE

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

(2016) Hyowon Choi et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Advances in biological therapy for nucleus pulposus regeneration

(2016) P. Priyadarshani et al.   OSTEOARTHRITIS AND CARTILAGE

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Hinokitiol, a tropolone derivative, inhibits mouse melanoma (B16-F10) cell migration and in vivo tumor formation

(2015) Chien-Hsun Huang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLCγ1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells

(2015) Po-Sheng Yang et al.   MOLECULES

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Mechanics and biology in intervertebral disc degeneration: a vicious circle

(2015) P.-P.A. Vergroesen et al.   OSTEOARTHRITIS AND CARTILAGE

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

The Responses of Autophagy and Apoptosis to Oxidative Stress in Nucleus Pulposus Cells: Implications for Disc Degeneration

(2014) Jiang-Wei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The benefits of multi-disciplinary research on intervertebral disc degeneration

(2014) Hans-Joachim Wilke et al.   EUROPEAN SPINE JOURNAL

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

(2013) Kuan H. Lin et al.   BIOCHEMICAL PHARMACOLOGY

Primary prevention of disc degeneration-related symptoms

(2013) Aron Lazary et al.   EUROPEAN SPINE JOURNAL

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate

(2012) Yung-Hsin Cheng et al.   CARBOHYDRATE POLYMERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

The Effect of Injection Volume on Disc Degeneration in a Rat Tail Model

(2011) Hua-jie Mao et al.   SPINE

Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux

(2010) M.-B. Troadec et al.   BLOOD

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE