Dynamic Kinetic Resolution of α-Trifluoromethyl Hemiaminals without α-Hydrogen via NHC-Catalyzed O-Acylation

Bifunctional N-Heterocyclic Carbenes Derived from l-Pyroglutamic Acid and Their Applications in Enantioselective Organocatalysis

(2020) Xiang-Yu Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Access to Optically Enriched α-Aryloxycarboxylic Esters via Carbene-Catalyzed Dynamic Kinetic Resolution and Transesterification

(2020) Bin Liu et al.   ORGANIC LETTERS

NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles

(2019) Santigopal Mondal et al.   ACCOUNTS OF CHEMICAL RESEARCH

2018 FDA drug approvals

(2019) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Kinetic Resolution, Dynamic Kinetic Resolution and Asymmetric Desymmetrization by N-Heterocyclic Carbene Catalysis

(2019) Carmela De Risi et al.   SYNTHESIS-STUTTGART

Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs

(2019) Yingguo Liu et al.   Nature Communications

Carbene-Catalyzed Dynamic Kinetic Resolution and Asymmetric Acylation of Hydroxyphthalides and Related Natural Products

(2019) Yingguo Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed ε-Umpolung via p-Quinodimethanes and Its Nucleophilic Addition to Ketones

(2019) Lei Dai et al.   ACS Catalysis

N-Heterocyclic Carbene Catalysis via Azolium Dienolates: An Efficient Strategy for Remote Enantioselective Functionalizations

(2018) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Organocatalyzed Kinetic Resolutions, Dynamic Kinetic Resolutions and Desymmetrizations

(2018) Zhongyao Wang et al.   Chemistry-An Asian Journal

Recent Progress in (Dynamic) Kinetic Resolution Catalyzed by N -Heterocyclic Carbenes

(2018) Shihao Chen et al.   Chemistry-An Asian Journal

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Asymmetric Synthesis of Chiral Acyclic Purine Nucleosides Containing a Hemiaminal Ester Moiety via Three-Component Dynamic Kinetic Resolution

(2018) Ming-Sheng Xie et al.   ORGANIC LETTERS

Kinetic Resolution of 1,2-Diols via NHC-Catalyzed Site-Selective Esterification

(2018) Bin Liu et al.   ORGANIC LETTERS

Enantioselective N-Heterocyclic Carbene-Catalyzed Kinetic Resolution of Anilides

(2018) Jianbo Bie et al.   ORGANIC LETTERS

(Dynamic) Kinetic Resolution of Enamines/Imines: Enantioselective N-Heterocyclic Carbene Catalyzed [3+3] Annulation of Bromoenals and Enamines/Imines

(2018) Kun-Quan Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Chiral DMAP Catalyst for the Dynamic Kinetic Resolution of Azole Hemiaminals

(2017) Artis Kinens et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene Catalysis via the α,β-Unsaturated Acyl Azolium

(2017) Changhe Zhang et al.   ACS Catalysis

N-Heterocyclic Carbene-Catalyzed Aldol-Lactonization of Ketoacids via Dynamic Kinetic Resolution

(2017) Santigopal Mondal et al.   ACS Catalysis

Recent advances in N-heterocyclic carbene (NHC)-catalysed benzoin reactions

(2016) Rajeev S Menon et al.   Beilstein Journal of Organic Chemistry

Organocatalytic Kinetic Resolution of Sulfoximines

(2016) Shunxi Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters

(2016) Xingkuan Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and Enantioselective Synthesis of Azole Hemiaminal Esters by Lewis Base Catalyzed Dynamic Kinetic Resolution

(2016) David W. Piotrowski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent Developments in Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones and Imines through Dynamic Kinetic Resolution

(2016) Phannarath Phansavath et al.   SYNTHESIS-STUTTGART

N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones

(2015) Changgui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Chemoenzymatic Dynamic Kinetic Resolution: A Powerful Tool for the Preparation of Enantiomerically Pure Alcohols and Amines

(2015) Oscar Verho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid

(2014) Zijun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols through NHC-Catalyzed Atroposelective Acylation

(2014) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene-Catalyzed [3+4] Cycloaddition and Kinetic Resolution of Azomethine Imines

(2014) Ming Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3-Hydroxy-3-Substituted Oxindoles

(2013) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Cocatalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols

(2013) Satoru Kuwano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Cycloaddition Reactions of Ketenes Catalyzed by N-Heterocyclic Carbenes

(2013) Song Ye et al.   SYNLETT

Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones

(2012) Daniel T. Cohen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative N-Heterocyclic Carbene Catalysis

(2012) Christiane E. I. Knappke et al.   ChemCatChem

Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis

(2012) Junming Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalyzed Dynamic Kinetic Resolution

(2011) Hélène Pellissier   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene-Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

(2011) Li-Tao Shen et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Enantioselective Acyl Transfer onto Racemic as well as meso Alcohols, Amines, and Thiols

(2011) Christian E. Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Kinetic Resolution of Cyclic Secondary Amines

(2011) Michael Binanzer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Resolution of Secondary Alcohols by NHC-Catalyzed Oxidative Esterification

(2011) Armido Studer et al.   SYNTHESIS-STUTTGART

Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselective Synthesis of Oxazolin-4-ones

(2010) Pan-Lin Shao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC Catalyzed Oxidations of Aldehydes to Esters: Chemoselective Acylation of Alcohols in Presence of Amines

(2010) Suman De Sarkar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis ofcis-4-Formyl-β-lactamsviaChiral N-Heterocyclic Carbene-Catalyzed Kinetic Resolution

(2008) Gong-Qiang Li et al.   ADVANCED SYNTHESIS & CATALYSIS

De-racemization of Enantiomers versus De-epimerization of Diastereomers-Classification of Dynamic Kinetic Asymmetric Transformations (DYKAT)

(2008) Johannes Steinreiber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dynamic kinetic resolution of hemiaminals using a novel DMAP catalyst

(2007) Shinji Yamada et al.   TETRAHEDRON LETTERS