National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials
出版年份 2021 全文链接
标题
National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials
作者
关键词
-
出版物
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2021-02-04
DOI
10.1093/gerona/glab028
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A proteomic atlas of senescence-associated secretomes for aging biomarker development
- (2020) Nathan Basisty et al. PLOS BIOLOGY
- Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging
- (2020) Harikrishnan Thoppil et al. Frontiers in Cell and Developmental Biology
- The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications
- (2020) Nathan Basisty et al. Expert Review of Proteomics
- Safety, tolerability, pharmacokinetics, and clinical outcomes following treatment of painful knee osteoarthritis with senolytic molecule UBX0101
- (2020) B. Hsu et al. OSTEOARTHRITIS AND CARTILAGE
- Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells
- (2020) Sabena M. Conley et al. Frontiers in Cell and Developmental Biology
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
- (2019) Jamie N. Justice et al. EBioMedicine
- Clinical Studies on Drug‐Drug Interactions Involving Metabolism and Transport: Methodology, Pitfalls and Interpretation
- (2019) Aleksi Tornio et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Senolytic therapies for healthy longevity
- (2019) Jan M. van Deursen SCIENCE
- Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response?
- (2019) Viktor Martyanov et al. Arthritis & Rheumatology
- Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
- (2019) Sonja Suvakov et al. Biology of Sex Differences
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Cellular Senescence: Defining a Path Forward
- (2019) Vassilis Gorgoulis et al. CELL
- Plasma proteomic signature of age in healthy humans
- (2018) Toshiko Tanaka et al. AGING CELL
- Selective inhibition of CYP2C8 by fisetin and its methylated metabolite, geraldol, in human liver microsomes
- (2018) Riya Shrestha et al. Drug Metabolism and Pharmacokinetics
- Dasatinib increases endothelial permeability leading to pleural effusion
- (2018) Carole Phan et al. EUROPEAN RESPIRATORY JOURNAL
- A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects
- (2018) Ellen Kraig et al. EXPERIMENTAL GERONTOLOGY
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- TORC1 inhibition enhances immune function and reduces infections in the elderly
- (2018) Joan B. Mannick et al. Science Translational Medicine
- Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia
- (2018) Timothy P. Hughes et al. HAEMATOLOGICA
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- Senescence and senotherapeutics: a new field in cancer therapy
- (2018) Vassilios Myrianthopoulos et al. PHARMACOLOGY & THERAPEUTICS
- Fisetin is a senotherapeutic that extends health and lifespan
- (2018) Matthew J. Yousefzadeh et al. EBioMedicine
- The bystander effect contributes to the accumulation of senescent cells in vivo
- (2018) Paulo F. L. da Silva et al. AGING CELL
- First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile
- (2017) Giovanna Speranza et al. INVESTIGATIONAL NEW DRUGS
- Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia
- (2017) J Deng et al. LEUKEMIA
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- The emerging safety profile of JAK inhibitors in rheumatic disease
- (2017) Kevin L. Winthrop Nature Reviews Rheumatology
- Cellular senescence mediates fibrotic pulmonary disease
- (2017) Marissa J. Schafer et al. Nature Communications
- Identification of HSP90 inhibitors as a novel class of senolytics
- (2017) Heike Fuhrmann-Stroissnigg et al. Nature Communications
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
- (2016) Carolyn M. Roos et al. AGING CELL
- Senescent intimal foam cells are deleterious at all stages of atherosclerosis
- (2016) B. G. Childs et al. SCIENCE
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
- (2015) Remi-Martin Laberge et al. NATURE CELL BIOLOGY
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
- (2015) Ming Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting senescent cells enhances adipogenesis and metabolic function in old age
- (2015) Ming Xu et al. eLife
- First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors
- (2014) G. I. Shapiro et al. CLINICAL CANCER RESEARCH
- mTOR inhibition improves immune function in the elderly
- (2014) J. B. Mannick et al. Science Translational Medicine
- Inhibition of mTOR Signaling by Quercetin in Cancer Treatment and Prevention
- (2013) Ansgar Bruning Anti-Cancer Agents in Medicinal Chemistry
- A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas
- (2013) A. J. Wagner et al. CLINICAL CANCER RESEARCH
- A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors
- (2013) Dan Zhou et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan
- (2012) Michael J. Steinbaugh et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Fisetin: A Dietary Antioxidant for Health Promotion
- (2012) Naghma Khan et al. ANTIOXIDANTS & REDOX SIGNALING
- A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis
- (2012) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
- (2011) Leena Gandhi et al. JOURNAL OF CLINICAL ONCOLOGY
- Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non–Small-Cell Lung Cancer
- (2010) Lecia V. Sequist et al. JOURNAL OF CLINICAL ONCOLOGY
- Dynamics and management of cytopenias associated with dasatinib therapy in patients with chronic myeloid leukemia in chronic phase after imatinib failure
- (2009) Alfonso Quintás-Cardama et al. CANCER
- Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies
- (2009) Shivaani Kummar et al. EUROPEAN JOURNAL OF CANCER
- Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery
- (2009) M. Amolins et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma
- (2008) D. B. Solit et al. CLINICAL CANCER RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now