Plant molecular farming for the production of valuable proteins – Critical evaluation of achievements and future challenges

Plant‐derived protein bodies as delivery vehicles for recombinant proteins into mammalian cells

(2020) Jennifer Schwestka et al.   BIOTECHNOLOGY AND BIOENGINEERING

Developments in the treatment of Fabry disease

(2020) Sanne J. Veen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Potential Applications of Plant Biotechnology against SARS-CoV-2

(2020) Teresa Capell et al.   TRENDS IN PLANT SCIENCE

What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?

(2020) Sergio Rosales-Mendoza et al.   Vaccines

Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials

(2020) Brian J Ward et al.   LANCET

Plant‐made dengue virus‐like particles produced by co‐expression of structural and non‐structural proteins induce a humoral immune response in mice

(2020) Daniel Ponndorf et al.   PLANT BIOTECHNOLOGY JOURNAL

Immunization with Plant-Derived Multimeric H5 Hemagglutinins Protect Chicken against Highly Pathogenic Avian Influenza Virus H5N1

(2020) Hoang Trong Phan et al.   Vaccines

Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins

(2019) Stefan Schillberg et al.   Frontiers in Plant Science

Edible Vaccines: Promises and Challenges

(2019) Vrinda M Kurup et al.   MOLECULAR BIOTECHNOLOGY

Plant-Made Bet v 1 for Molecular Diagnosis

(2019) Mattia Santoni et al.   Frontiers in Plant Science

Using carrot cells as biofactories and oral delivery vehicles of LTB-Syn: A low-cost vaccine candidate against synucleinopathies

(2019) Jaime I. Arevalo-Villalobos et al.   JOURNAL OF BIOTECHNOLOGY

Long-term safety and efficacy of taliglucerase alfa in pediatric Gaucher disease patients who were treatment-naïve or previously treated with imiglucerase

(2018) Ari Zimran et al.   BLOOD CELLS MOLECULES AND DISEASES

Taliglucerase alfa: safety and efficacy across 6 clinical studies in adults and children with Gaucher disease

(2018) Ari Zimran et al.   Orphanet Journal of Rare Diseases

A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity

(2018) Huafang Lai et al.   VACCINE

Improvement of the transient expression system for production of recombinant proteins in plants

(2018) Tsuyoshi Yamamoto et al.   Scientific Reports

Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination

(2017) Jihong Liu Clarke et al.   PLANT BIOTECHNOLOGY JOURNAL

Combination of two epitope identification techniques enables the rational design of soy allergen Gly m 4 mutants

(2017) Heide Havenith et al.   Biotechnology Journal

Combined 15N-Labeling and TandemMOAC Quantifies Phosphorylation of MAP Kinase Substrates Downstream of MKK7 in Arabidopsis

(2017) Nicola V. Huck et al.   Frontiers in Plant Science

Enzyme replacement therapy with taliglucerase alfa: 36-month safety and efficacy results in adult patients with Gaucher disease previously treated with imiglucerase

(2016) Gregory M. Pastores et al.   AMERICAN JOURNAL OF HEMATOLOGY

The case for plant-made veterinary immunotherapeutics

(2016) Edward Topp et al.   BIOTECHNOLOGY ADVANCES

Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins

(2016) Zulfaquar Ahmad Arfi et al.   Biotechnology Journal

Potential of plants to produce recombinant protein products

(2016) Ky Young Park et al.   JOURNAL OF PLANT BIOLOGY

CHO cell production and sequence improvement in the 13C6FR1 anti-Ebola antibody

(2016) Dean K. Pettit et al.   mAbs

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

(2016) Xiangguo Qiu et al.   Science Translational Medicine

Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins

(2016) Zulfaquar Ahmad Arfi et al.   Biotechnology Journal

Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming

(2016) Manoj K. Mandal et al.   Frontiers in Plant Science

A versatile coupled cell-free transcription-translation system based on tobacco BY-2 cell lysates

(2015) Matthias Buntru et al.   BIOTECHNOLOGY AND BIOENGINEERING

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

(2015) Markus Sack et al.   PLANT BIOTECHNOLOGY JOURNAL

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

(2015) Julian K-C. Ma et al.   PLANT BIOTECHNOLOGY JOURNAL

High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures

(2015) Luisa M. Madeira et al.   PLANT BIOTECHNOLOGY JOURNAL

Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor

(2014) Nicole Raven et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Phase 3, multicenter, open-label, switchover trial to assess the safety and efficacy of taliglucerase alfa, a plant cell-expressed recombinant human glucocerebrosidase, in adult and pediatric patients with Gaucher disease previously treated with imiglucerase

(2014) Gregory M. Pastores et al.   BLOOD CELLS MOLECULES AND DISEASES

Image-based analysis of cell-specific productivity for plant cell suspension cultures

(2014) Heide Havenith et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Molecular farming in tobacco hairy roots by triggering the secretion of a pharmaceutical antibody

(2013) Suvi T. Häkkinen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Commercial Aspects of Pharmaceutical Protein Production in Plants

(2013) Rainer Fischer et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell and Tissue Cultures

(2013) Stefan Schillberg et al.   CURRENT PHARMACEUTICAL DESIGN

Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method

(2013) Nikolay Vasilev et al.   PLANT BIOTECHNOLOGY JOURNAL

Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection

(2013) V. Virdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Barley grains for the production of endotoxin-free growth factors

(2013) Audur Magnusdottir et al.   TRENDS IN BIOTECHNOLOGY

Antibody-mediated resistance against plant pathogens

(2011) Mohammad Reza Safarnejad et al.   BIOTECHNOLOGY ADVANCES

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Comprehensive characterization of two different Nicotiana tabacum cell lines leads to doubled GFP and HA protein production by media optimization

(2011) David A. Ullisch et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Force Majeure: Therapeutic measures in response to restricted supply of imiglucerase (Cerezyme) for patients with Gaucher disease

(2009) Carla E.M. Hollak et al.   BLOOD CELLS MOLECULES AND DISEASES