Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

The increasing value of plant-made proteins

(2015) Markus Sack et al.   CURRENT OPINION IN BIOTECHNOLOGY

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12

(2015) Evangelia Vamvaka et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases

(2014) Eva Stoger et al.   Annual Review of Plant Biology

US signs contract with ZMapp maker to accelerate development of the Ebola drug

(2014) M. McCarthy   BMJ-British Medical Journal

Target Product Selection - Where Can Molecular Pharming Make the Difference?

(2013) Mathew Paul et al.   CURRENT PHARMACEUTICAL DESIGN

Realising the value of plant molecular pharming to benefit the poor in developing countries and emerging economies

(2013) Julian K-C. Ma et al.   PLANT BIOTECHNOLOGY JOURNAL

Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems

(2013) Yvonne Rosenberg et al.   PLoS One

Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

(2013) Yunji Wu et al.   Cell Reports

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

(2012) G. G. Olinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GMP issues for recombinant plant-derived pharmaceutical proteins

(2011) Rainer Fischer et al.   BIOTECHNOLOGY ADVANCES

Broad neutralization coverage of HIV by multiple highly potent antibodies

(2011) Laura M. Walker et al.   NATURE

Phase I Randomised Clinical Trial of an HIV-1CN54, Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally

(2011) David J. Lewis et al.   PLoS One

Can Microbicides Turn the Tide Against HIV?

(2010) Koreen Ramessar et al.   CURRENT PHARMACEUTICAL DESIGN

Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana

(2010) Andreas Loos et al.   PLANT BIOTECHNOLOGY JOURNAL

Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

(2010) Frank Sainsbury et al.   PLoS One

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

(2009) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

Design and Expression of a Dimeric Form of Human Immunodeficiency Virus Type 1 Antibody 2G12 with Increased Neutralization Potency

(2008) A. P. West et al.   JOURNAL OF VIROLOGY

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission

(2008) K. Ramessar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides

(2008) Johannes Stadlmann et al.   PROTEOMICS

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination

(2008) Victoria R. Polonis et al.   VIROLOGY

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans

(2007) Thomas Rademacher et al.   PLANT BIOTECHNOLOGY JOURNAL