期刊
BIOTECHNOLOGY ADVANCES
卷 34, 期 5, 页码 597-604出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2016.02.007
关键词
Veterinary vaccine; Immunotherapeutic; Antibody; Recombinant protein; Plant biotechnology; Molecular farming; Livestock production; Antibiotic resistance
资金
- OECD Co-operative Research Programme on Biological Resource Management for Sustainable Agricultural Systems
The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
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