Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

The Sum of All Browning in FGF21 Therapeutics

(2015) Paul Lee et al.   Cell Metabolism

Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry

(2015) Takeshi Katafuchi et al.   Cell Metabolism

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

(2015) Xiaoqing Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

(2015) Rucha Patel et al.   MOLECULAR ENDOCRINOLOGY

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

(2015) W Y So et al.   Cell Death & Disease

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

(2015) M. Hagel et al.   Cancer Discovery

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

(2015) Ricardo J. Samms et al.   Cell Reports

Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

(2015) Yan Weng et al.   PLoS One

A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog

(2014) Lintao Song et al.   BIOMATERIALS

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

(2014) M. Zhou et al.   CANCER RESEARCH

Fibroblast growth factor 21 protects the heart from oxidative stress

(2014) Anna Planavila et al.   CARDIOVASCULAR RESEARCH

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

(2014) Shuangwei Li et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

Hepatocyte FRS2α is Essential for the Endocrine Fibroblast Growth Factor to Limit the Amplitude of Bile Acid Production Induced by Prandial Activity

(2014) C. Wang et al.   CURRENT MOLECULAR MEDICINE

FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting

(2014) Q. Liang et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation

(2014) Chiara Degirolamo et al.   HEPATOLOGY

Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development

(2014) Iker Uriarte et al.   INTERNATIONAL JOURNAL OF CANCER

Fibroblast Growth Factor Receptor 4 (FGFR4) Deficiency Improves Insulin Resistance and Glucose Metabolism under Diet-induced Obesity Conditions

(2014) Hongfei Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between FGF21 and insulin action in the liver regulates metabolism

(2014) Brice Emanuelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

(2014) Thomas O. Carpenter et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular interactions of FGF23 and PTH in phosphate regulation

(2014) Beate Lanske et al.   KIDNEY INTERNATIONAL

Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription

(2014) Tomer Meir et al.   KIDNEY INTERNATIONAL

Treatment of established left ventricular hypertrophy with fibroblast growth factor receptor blockade in an animal model of CKD

(2014) G. S. Di Marco et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

(2014) J. Luo et al.   Science Translational Medicine

FGF21-based pharmacotherapy – potential utility for metabolic disorders

(2014) Ruth E. Gimeno et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inventing new medicines: The FGF21 story

(2014) Alexei Kharitonenkov et al.   Molecular Metabolism

FGF23 is a novel regulator of intracellular calcium and cardiac contractility in addition to cardiac hypertrophy

(2013) Chad D. Touchberry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells

(2013) Masaaki Miyata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

(2013) Jing Xu et al.   BIOCONJUGATE CHEMISTRY

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

(2013) Laurent Vergnes et al.   Cell Metabolism

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

High Glucose Represses  -Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator-Activated Receptor   Signaling

(2013) W. Y. So et al.   DIABETES

Expression of Fibroblast Growth Factor 19 Is Associated with Recurrence and Poor Prognosis of Hepatocellular Carcinoma

(2013) Jiyeon Hyeon et al.   DIGESTIVE DISEASES AND SCIENCES

Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome

(2013) Jun Zhang et al.   DRUG DISCOVERY TODAY

Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

(2013) Raul C. Camacho et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased fibroblast growth factor 21 expression in high-fat diet-sensitive non-human primates (Macaca mulatta)

(2013) E B Nygaard et al.   INTERNATIONAL JOURNAL OF OBESITY

Retinoic Acid Receptor β Stimulates Hepatic Induction of Fibroblast Growth Factor 21 to Promote Fatty Acid Oxidation and Control Whole-body Energy Homeostasis in Mice

(2013) Yu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF21 mediates the lipid metabolism response to amino acid starvation

(2013) Ana Luísa De Sousa-Coelho et al.   JOURNAL OF LIPID RESEARCH

Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue

(2013) Elayne Hondares et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FGF21 contributes to neuroendocrine control of female reproduction

(2013) Bryn M Owen et al.   NATURE MEDICINE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

(2013) Alexei Kharitonenkov et al.   PLoS One

Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia

(2013) Ai-Luen Wu et al.   PLoS One

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

(2013) Richard Smith et al.   PLoS One

Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

(2013) Xing Xian Yu et al.   PLoS One

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

(2013) A. Planavila et al.   Nature Communications

Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue

(2013) Shu Q. Liu et al.   Scientific Reports

Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones

(2013) Andrew C. Adams et al.   Molecular Metabolism

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

(2013) Geneviève Marcelin et al.   Molecular Metabolism

FGF19(fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress

(2012) Makoto Shimizu et al.   BIOCHEMICAL JOURNAL

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

(2012) Seiki Miura et al.   BMC CANCER

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway

(2012) Olena Andrukhova et al.   BONE

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives

(2012) Y. C. Woo et al.   CLINICAL ENDOCRINOLOGY

Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3

(2012) H. Li et al.   DIABETES

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

Metformin Stimulates FGF21 Expression in Primary Hepatocytes

(2012) Eva B. Nygaard et al.   Experimental Diabetes Research

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

Nuclear Receptors HNF4α and LRH-1 Cooperate in RegulatingCyp7a1 in Vivo

(2012) Serkan Kir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

(2012) Holly A. Cyphert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

(2012) Victoria Shalhoub et al.   JOURNAL OF CLINICAL INVESTIGATION

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

(2012) Timo D. Müller et al.   JOURNAL OF PEPTIDE SCIENCE

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19

(2012) Masaaki Miyata et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeted Deletion of Klotho in Kidney Distal Tubule Disrupts Mineral Metabolism

(2012) H. Olauson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism

(2012) L. Darryl Quarles   Nature Reviews Endocrinology

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models

(2012) Dorothy M. French et al.   PLoS One

FGF21 Requires βklotho to Act In Vivo

(2012) Andrew C. Adams et al.   PLoS One

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

(2012) Randy Hecht et al.   PLoS One

Regulation of Amphiregulin Gene Expression by β-Catenin Signaling in Human Hepatocellular Carcinoma Cells: A Novel Crosstalk between FGF19 and the EGFR System

(2012) Maria U. Latasa et al.   PLoS One

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor  

(2012) W. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the  Klotho/FGFR1c Receptor Complex

(2012) I. N. Foltz et al.   Science Translational Medicine

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

(2012) Rama Pai et al.   TOXICOLOGICAL SCIENCES

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

(2012) Andrew C. Adams et al.   Molecular Metabolism

Various Oscillation Patterns of Serum Fibroblast Growth Factor 21 Concentrations in Healthy Volunteers

(2012) Sang Ah Lee et al.   Diabetes & Metabolism Journal

Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice

(2011) Katsutaka Oishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thiazolidinediones Are Potent Inducers of Fibroblast Growth Factor 21 Expression in the Liver

(2011) Katsutaka Oishi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

(2011) H. Yu et al.   CLINICAL CHEMISTRY

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers

(2011) Birgitte Andersen et al.   CLINICAL ENDOCRINOLOGY

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

'Dem bones' are made for more than walking

(2011) L Darryl Quarles   NATURE MEDICINE

Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients

(2011) E. Gonzalez-Parra et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cinacalcet treatment and serum FGF23 levels in haemodialysis patients with secondary hyperparathyroidism

(2011) M. Koizumi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

FGF19 Regulates Cell Proliferation, Glucose and Bile Acid Metabolism via FGFR4-Dependent and Independent Pathways

(2011) Ai-Luen Wu et al.   PLoS One

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol

(2011) Zhifeng Huang et al.   PLoS One

The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis

(2011) Mark R. Haussler et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

(2010) Tim C. M. A. Schreuder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease

(2010) Nobuyuki Itoh   CELL AND TISSUE RESEARCH

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats

(2010) D. A. Sarruf et al.   DIABETES

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

(2010) f. M. Fisher et al.   DIABETES

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

(2010) Ming Chang Hu et al.   FASEB JOURNAL

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

Bile acid malabsorption in inflammatory bowel disease

(2010) Martin Lenicek et al.   INFLAMMATORY BOWEL DISEASES

Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in aPPARα-dependent Manner

(2010) Andrew C. Adams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D

(2010) Daniel R. Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob/ob Mice

(2010) Kiyomi Tsuji et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice

(2010) Anne S. Henkel et al.   JOURNAL OF LIPID RESEARCH

Increased parathyroid expression of klotho in uremic rats

(2010) Jacob Hofman-Bang et al.   KIDNEY INTERNATIONAL

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Recent advances in renal phosphate handling

(2010) Emily G. Farrow et al.   Nature Reviews Nephrology

Serum Levels of FGF-21 Are Increased in Coronary Heart Disease Patients and Are Independently Associated with Adverse Lipid Profile

(2010) Zhuofeng Lin et al.   PLoS One

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical generation of bispecific antibodies

(2010) V. R. Doppalapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population

(2009) Majd A.I. Mirza et al.   ATHEROSCLEROSIS

Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease

(2009) Orlando M. Gutiérrez et al.   CIRCULATION

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

(2009) Charis L. Johnson et al.   GASTROENTEROLOGY

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

(2009) J. Miao et al.   GENES & DEVELOPMENT

Fibroblast Growth Factor 19 Serum Levels: Relation to Renal Function and Metabolic Parameters

(2009) M. Reiche et al.   HORMONE AND METABOLIC RESEARCH

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic Effects of Anti-FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia*

(2009) Yukiko Aono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

(2009) Constantinos Christodoulides et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase

(2009) Mutsuko Ohnishi et al.   KIDNEY INTERNATIONAL

Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease

(2009) H. Galitzer et al.   KIDNEY INTERNATIONAL

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients

(2009) Hirotaka Komaba et al.   KIDNEY INTERNATIONAL

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Relationship between circulating FGF23 and total body atherosclerosis in the community

(2009) Majd A. I. Mirza et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice

(2009) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating  -Catenin Signaling

(2008) R. Pai et al.   CANCER RESEARCH

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity

(2008) M. Mraz et al.   CLINICAL ENDOCRINOLOGY

Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion

(2008) Hillel Galitzer et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Circadian expression ofFGF21is induced by PPARα activation in the mouse liver

(2008) Katsutaka Oishi et al.   FEBS LETTERS

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY

C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors

(2008) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-FGF23 Neutralizing Antibodies Show the Physiological Role and Structural Features of FGF23

(2008) Yuji Yamazaki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa

(2008) Ivana Dostálová et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis

(2008) Youn-Kyoung Lee et al.   MOLECULAR ENDOCRINOLOGY

Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor   and Altered Metabolic States

(2008) E. S. Muise et al.   MOLECULAR PHARMACOLOGY

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE

FGF-21/FGF-21 receptor interaction and activation is determined by βKlotho

(2007) Alexei Kharitonenkov et al.   JOURNAL OF CELLULAR PHYSIOLOGY