Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine)

Installation of a Thermoswitchable Hydrophobic Domain into a Unimer Polyion Complex for Enhanced Cellular Uptake of siRNA

(2020) Beob Soo Kim et al.   BIOCONJUGATE CHEMISTRY

Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines

(2020) Anjaneyulu Dirisala et al.   Science Advances

Treating Disease at the RNA Level with Oligonucleotides

(2019) Arthur A. Levin   NEW ENGLAND JOURNAL OF MEDICINE

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers

(2019) Sumiyo Watanabe et al.   Nature Communications

Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer

(2019) Theofilus A. Tockary et al.   ACS Nano

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Small Delivery Vehicles of siRNA for Enhanced Cancer Targeting

(2018) Hyun Jin Kim et al.   BIOMACROMOLECULES

Block Copolymer Micelles in Nanomedicine Applications

(2018) Horacio Cabral et al.   CHEMICAL REVIEWS

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

The chemical evolution of oligonucleotide therapies of clinical utility

(2017) Anastasia Khvorova et al.   NATURE BIOTECHNOLOGY

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Recent progress in development of siRNA delivery vehicles for cancer therapy

(2016) Hyun Jin Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers

(2016) Kotaro Hayashi et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

(2016) Keisuke Katsushima et al.   Nature Communications

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

(2015) Horacio Cabral et al.   ACS Nano

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Oligonucleotide Therapies: The Past and the Present

(2015) Karin E. Lundin et al.   HUMAN GENE THERAPY

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

(2015) Kazutaka Nishina et al.   Nature Communications

Nanosized Multifunctional Polyplexes for Receptor-Mediated SiRNA Delivery

(2012) Christian Dohmen et al.   ACS Nano

Single siRNA Nanocapsules for Enhanced RNAi Delivery

(2012) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of Polymer Structure on Micelles Formed between siRNA and Cationic Block Copolymer Comprising Thiols and Amidines

(2011) R. James Christie et al.   BIOMACROMOLECULES

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

(2009) Adam D. Judge et al.   JOURNAL OF CLINICAL INVESTIGATION