Neuroprotective Effects of the FGF21 Analogue LY2405319

Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ

(2020) Bruno Chausse et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective Effect of Antioxidants in the Brain

(2020) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer’s disease

(2019) Song Chen et al.   Redox Biology

Effect of genotype and age on cerebral [18F]FDG uptake varies between transgenic APPSwe-PS1dE9 and Tg2576 mouse models of Alzheimer’s disease

(2019) Anniina Snellman et al.   Scientific Reports

Organotypic brain slice cultures to model neurodegenerative proteinopathies

(2019) C. L. Croft et al.   Molecular Neurodegeneration

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

(2018) Sangwon Lee et al.   NATURE

Alzheimer’s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults

(2017) Julien Dumurgier et al.   JOURNAL OF ALZHEIMERS DISEASE

Assessment of change in glucose metabolism in white matter of amyloid-positive patients with Alzheimer disease using F-18 FDG PET

(2017) Young Jin Jeong et al.   MEDICINE

APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study

(2017) Angela Kuhla et al.   NeuroImage-Clinical

Potential roles of fibroblast growth factor 21 in the brain

(2016) Piangkwan Sa-nguanmoo et al.   METABOLIC BRAIN DISEASE

Fibroblast growth factor-21, energy balance and obesity

(2015) Marta Giralt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319

(2013) Alexei Kharitonenkov et al.   PLoS One

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice

(2012) Shuang-qing Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease

(2012) Rachna Gupta et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

(2012) Chaofeng Yang et al.   PLoS One

Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis

(2011) Eleni M Domouzoglou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease

(2011) Huaqi Xiong et al.   Neuroscience Bulletin

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

FGFs and metabolism

(2009) Alexei Kharitonenkov   CURRENT OPINION IN PHARMACOLOGY

Individual cerebral metabolic deficits in Alzheimer’s disease and amnestic mild cognitive impairment: an FDG PET study

(2008) Angelo Del Sole et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING