Disruption of the Complex between GAPDH and Hsp70 Sensitizes C6 Glioblastoma Cells to Hypoxic Stress

Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma

(2020) Lingjuan Huang et al.   CELL STRESS & CHAPERONES

HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy

(2020) Ameneh Jafari et al.   CANCER INVESTIGATION

Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression

(2020) Marco Papale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Trends of microRNA Significance in Pediatric Population Glioblastoma and Current Knowledge of Micro RNA Function in Glioblastoma Multiforme

(2020) Marek Mazurek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hsp70-mediated quality control: should I stay or should I go?

(2020) Verena Kohler et al.   BIOLOGICAL CHEMISTRY

The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies

(2020) Subhabrata Chaudhury et al.   MEDICINAL RESEARCH REVIEWS

Molecular chaperone HSP70 and key regulators of apoptosis

(2019) Rabih Roufayel   CURRENT MOLECULAR MEDICINE

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis

(2019) Maria V. Liberti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy

(2019) Chul Won Yun et al.   Cells

Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

(2019) Mark Zaidi et al.   Frontiers in Bioengineering and Biotechnology

Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

(2018) Vladimir F. Lazarev et al.   Cell Death & Disease

Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis

(2018) Maryam Mehrabi et al.   Frontiers in Oncology

Peptide fragments of Hsp70 modulate its chaperone activity and sensitize tumor cells to anti-cancer drugs

(2017) Dmitry V. Sverchinsky et al.   FEBS LETTERS

Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells

(2017) Iman Azimi et al.   Scientific Reports

Hsp70 chaperone rescues C6 rat glioblastoma cells from oxidative stress by sequestration of aggregating GAPDH

(2016) Vladimir F. Lazarev et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death

(2016) Takeya Kubo et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Advances in the targeting of HIF-1α and future therapeutic strategies for glioblastoma multiforme

(2016) Gang Wang et al.   ONCOLOGY REPORTS

Oxidation of an Exposed Methionine Instigates the Aggregation of Glyceraldehyde-3-phosphate Dehydrogenase

(2014) Andre L. Samson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor–1 and associated upstream and downstream proteins in the pathophysiology and management of glioblastoma

(2014) Matthew Womeldorff et al.   Neurosurgical Focus

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

(2013) Annegret Kathagen et al.   ACTA NEUROPATHOLOGICA

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition

(2013) Anna Budina-Kolomets et al.   CANCER BIOLOGY & THERAPY

Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

(2013) Xiaokai Li et al.   ACS Medicinal Chemistry Letters

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

Kinetics of chaperone activity of proteins Hsp70 and Hdj1 in human leukemia U-937 cells after preconditioning with thermal shock or compound U-133

(2011) V. F. Lazarev et al.   BIOCHEMISTRY-MOSCOW

Glyceraldehyde-3-phosphate dehydrogenase: activity inhibition and protein overexpression in rotenone models for Parkinson's disease

(2011) J. Huang et al.   NEUROSCIENCE

An aggregate-prone mutant of human glyceraldehyde-3-phosphate dehydrogenase augments oxidative stress-induced cell death in SH-SY5Y cells

(2009) Hidemitsu Nakajima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of glyceraldehyde-3-phosphate dehydrogenase in rotenone-induced cell apoptosis: Relevance to protein misfolding and aggregation

(2009) Jinsha Huang et al.   BRAIN RESEARCH

Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

(2009) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY