Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70)

(2016) Xiaokai Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells

(2016) Aoife McKeon et al.   MOLECULES

Knock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells

(2016) Darya A. Meshalkina et al.   Oncotarget

Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma

(2015) Sergey V. Abkin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors

(2015) Yanqun Zeng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

GAPDH binders as potential drugs for the therapy of polyglutamine diseases: Design of a new screening assay

(2015) Vladimir F. Lazarev et al.   FEBS LETTERS

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity

(2015) Maxim A. Shevtsov et al.   Oncotarget

Protein chaperones: a composition of matter review (2008 – 2013)

(2014) Tony Taldone et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70

(2014) Maxim A. Shevtsov et al.   INTERNATIONAL JOURNAL OF CANCER

Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

(2014) Pingfeng Zhang et al.   PLoS One

Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition

(2013) Anna Budina-Kolomets et al.   CANCER BIOLOGY & THERAPY

Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy

(2013) Irina V. Guzhova et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?

(2013) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ

(2012) Joel A. Cassel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Novel mechanism of Hsp70 chaperone-mediated prevention of polyglutamine aggregates in a cellular model of huntington disease

(2011) I. V. Guzhova et al.   HUMAN MOLECULAR GENETICS

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL