Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

(2013) Joydeep Mukherjee et al.   PLoS One

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

(2012) Lindy E. Barrett et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Microarray Analysis Verifies Two Distinct Phenotypes of Glioblastomas Resistant to Antiangiogenic Therapy

(2012) M. DeLay et al.   CLINICAL CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Novel ways to target brain tumour metabolism

(2011) Daniel Stieber et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target

(2011) Alexander Schulte et al.   GLIA

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

(2011) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

(2011) Manfred Westphal et al.   NATURE REVIEWS NEUROSCIENCE

Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study

(2011) E. Hattingen et al.   NEURO-ONCOLOGY

Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma

(2011) Olivier Keunen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach

(2011) G.U. Balcke et al.   TOXICOLOGY LETTERS

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Hypoxia and energetic tumour metabolism

(2010) M Christiane Brahimi-Horn et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glucose is necessary for stabilization of hypoxia-inducible factor-1α under hypoxia: Contribution of the pentose phosphate pathway to this stabilization

(2010) Mayuko Osada-Oka et al.   FEBS LETTERS

Metabolic alterations induced by ischemia in primary cultures of astrocytes: merging13C NMR spectroscopy and metabolic flux analysis

(2010) Ana I. Amaral et al.   JOURNAL OF NEUROCHEMISTRY

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Glioblastoma Stem Cells: A Neuropathologist's View

(2010) Roger E. McLendon et al.   Journal of Oncology

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In vitro

(2009) A. M. McCord et al.   MOLECULAR CANCER RESEARCH

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Expression of Transketolase-like 1 and Activation of Akt in Grade IV Glioblastomas Compared With Grades II and III Astrocytic Gliomas

(2008) Hans-Ullrich Völker et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

(2008) Corinne E. Griguer et al.   PLoS One

Hypoxia and HIF1α Repress the Differentiative Effects of BMPs in High-Grade Glioma

(2008) Francesca Pistollato et al.   STEM CELLS