Targeting Microglia-Synapse Interactions in Alzheimer’s Disease

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

(2020) Harald Hampel et al.   Frontiers in Immunology

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

(2020) Francesca Cignarella et al.   ACTA NEUROPATHOLOGICA

Microglia in Alzheimer's disease: A target for immunotherapy

(2019) Shoutang Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Unifying Hypothesis for Alzheimer’s Disease: From Plaques to Neurodegeneration

(2019) Frances A. Edwards   TRENDS IN NEUROSCIENCES

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease

(2019) Dalila Mango et al.   Frontiers in Pharmacology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Redox Signaling, Neuroinflammation, and Neurodegeneration

(2018) Gabriela Aguilera et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroinflammation in Alzheimer’s disease: Pleiotropic roles for cytokines and neuronal pentraxins

(2018) Ashley Swanson et al.   BEHAVIOURAL BRAIN RESEARCH

Microglia-Mediated Neuroprotection, TREM2 , and Alzheimer’s Disease: Evidence From Optical Imaging

(2018) Carlo Condello et al.   BIOLOGICAL PSYCHIATRY

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

(2018) Yuetiva Deming et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TREM2 regulates innate immunity in Alzheimer’s disease

(2018) Jiang-Tao Li et al.   Journal of Neuroinflammation

Microglia-Mediated Synapse Loss in Alzheimer's Disease

(2018) Lawrence Rajendran et al.   JOURNAL OF NEUROSCIENCE

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

(2018) Yingyue Zhou et al.   Frontiers in Aging Neuroscience

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

(2018) Cody Wolfe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

(2017) Gyun Jee Song et al.   Frontiers in Aging Neuroscience

Synaptoimmunology - roles in health and disease

(2017) Robert Nisticò et al.   Molecular Brain

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice

(2016) Nathaniel S. Woodling et al.   BRAIN

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

(2016) Adrian Olmos-Alonso et al.   BRAIN

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

NSAIDs protect neurons and preserve memory in a mouse model of AD

(2016) Hemi Malkki   Nature Reviews Neurology

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone

(2016) Annika Öhrfelt et al.   Multiple Sclerosis Journal

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease

(2015) Alessandro Tozzi et al.   NEUROBIOLOGY OF AGING

Subchronic Glucocorticoid Receptor Inhibition Rescues Early Episodic Memory and Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease

(2015) Fabien Lanté et al.   NEUROPSYCHOPHARMACOLOGY

Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis

(2015) Ismail Amr El-Shimy et al.   NEUROSCIENCE LETTERS

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Targeting TNF: a therapeutic strategy for Alzheimer's disease

(2014) Xin Cheng et al.   DRUG DISCOVERY TODAY

Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease

(2014) Jinghao Sheng et al.   GENE

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

(2013) Jared B. Vasquez et al.   NEUROSCIENCE LETTERS

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs for the Prevention of Alzheimers Disease

(2012) Greg M. Cole et al.   CNS & Neurological Disorders-Drug Targets

Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy

(2012) Robert Nisticò et al.   MOLECULAR NEUROBIOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

(2011) N Brouwers et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

(2011) C J Garwood et al.   Cell Death & Disease

Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling

(2010) Ofra Ben Menachem-Zidon et al.   BRAIN BEHAVIOR AND IMMUNITY

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo

(2009) Adrien W. Schmid et al.   HIPPOCAMPUS

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

Minocycline reduces the development of abnormal tau species in models of Alzheimer’s disease

(2008) Wendy Noble et al.   FASEB JOURNAL

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

(2008) S. Jimenez et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Neuroglia: the 150 years after

(2008) Helmut Kettenmann et al.   TRENDS IN NEUROSCIENCES