标题
Aberrant phase separation and cancer
作者
关键词
-
出版物
FEBS Journal
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2021-02-15
DOI
10.1111/febs.15765
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The emerging role of SPOP protein in tumorigenesis and cancer therapy
- (2020) Yizuo Song et al. Molecular Cancer
- Pan-cancer analysis of whole genomes
- (2020) NATURE
- Stress- and ubiquitylation-dependent phase separation of the proteasome
- (2020) Sayaka Yasuda et al. NATURE
- The repertoire of mutational signatures in human cancer
- (2020) Ludmil B. Alexandrov et al. NATURE
- Patterns of somatic structural variation in human cancer genomes
- (2020) Yilong Li et al. NATURE
- Phase separation organizes the site of autophagosome formation
- (2020) Yuko Fujioka et al. NATURE
- HSF1 phase transition mediates stress adaptation and cell fate decisions
- (2020) Giorgio Gaglia et al. NATURE CELL BIOLOGY
- BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates
- (2020) Nadra Al-Husini et al. MOLECULAR CELL
- Recent Synthetic Approaches towards Small Molecule Reactivators of p53
- (2020) Jerson L. Silva et al. Biomolecules
- Drugs enter a liquid phase
- (2020) Paulina Strzyz NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Partitioning of cancer therapeutics in nuclear condensates
- (2020) Isaac A. Klein et al. SCIENCE
- Protein phase separation: A novel therapy for cancer?
- (2020) Wei Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells
- (2019) Luciana P. Rangel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Aberrant Phase Transitions: Side Effects and Novel Therapeutic Strategies in Human Disease
- (2019) Veronica Verdile et al. Frontiers in Genetics
- Super-enhancers in cancer
- (2019) Palaniraja Thandapani PHARMACOLOGY & THERAPEUTICS
- Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly
- (2019) Sreejith J. Nair et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease
- (2019) Natalia B. Nedelsky et al. Nature Reviews Neurology
- Matter over mind: Liquid phase separation and neurodegeneration
- (2019) Shana Elbaum-Garfinkle JOURNAL OF BIOLOGICAL CHEMISTRY
- Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates
- (2019) Kristina N. Schaefer et al. DEVELOPMENTAL CELL
- Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
- (2019) Simon Alberti et al. CELL
- Modulation of p53 and prion protein aggregation by RNA
- (2019) Yraima Cordeiro et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series
- (2019) James Shorter JOURNAL OF BIOLOGICAL CHEMISTRY
- Stress granule: a promising target for cancer treatment
- (2019) Xiaomeng Gao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Genome organization around nuclear speckles
- (2019) Yu Chen et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments
- (2019) Sinan Kilic et al. EMBO JOURNAL
- Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma
- (2019) Jeremy J. Ryan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites
- (2019) Marta Alenquer et al. Nature Communications
- Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53
- (2019) Kiyoto Kamagata et al. Scientific Reports
- Liquid–Liquid Phase Separation in Disease
- (2019) Simon Alberti et al. Annual Review of Genetics
- The ubiquitin ligase adaptor SPOP in cancer
- (2019) Matthew J. Cuneo et al. FEBS Journal
- Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation
- (2019) Tae Hun Kim et al. SCIENCE
- Prion-like p53 Amyloids in Cancer
- (2019) Ambuja Navalkar et al. BIOCHEMISTRY
- Properties of Stress Granule and P-Body Proteomes
- (2019) Ji-Young Youn et al. MOLECULAR CELL
- Stress granules and neurodegeneration
- (2019) Benjamin Wolozin et al. NATURE REVIEWS NEUROSCIENCE
- Biomolecular condensates in neurodegeneration and cancer
- (2019) Stephanie Spannl et al. TRAFFIC
- The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration
- (2018) Peter St George-Hyslop et al. BRAIN RESEARCH
- Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
- (2018) Li Ding et al. CELL
- Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
- (2018) Mario Hofweber et al. CELL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Stress Granule Assembly Disrupts Nucleocytoplasmic Transport
- (2018) Ke Zhang et al. CELL
- Dynamic regulation of nucleolar architecture
- (2018) Attila Németh et al. CURRENT OPINION IN CELL BIOLOGY
- Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs
- (2018) Katsutoshi Imamura et al. EMBO JOURNAL
- Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior
- (2018) Titus Franzmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RGG/RG Motif Regions in RNA Binding and Phase Separation
- (2018) P. Andrew Chong et al. JOURNAL OF MOLECULAR BIOLOGY
- ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination
- (2018) Szilvia Juhász et al. MOLECULAR CELL
- Imaging dynamic and selective low-complexity domain interactions that control gene transcription
- (2018) Shasha Chong et al. SCIENCE
- A liquid phase of synapsin and lipid vesicles
- (2018) Dragomir Milovanovic et al. SCIENCE
- Coactivator condensation at super-enhancers links phase separation and gene control
- (2018) Benjamin R. Sabari et al. SCIENCE
- Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
- (2018) Won-Ki Cho et al. SCIENCE
- Phase separation of a yeast prion protein promotes cellular fitness
- (2018) Titus M. Franzmann et al. SCIENCE
- Paraspeckles: Where Long Noncoding RNA Meets Phase Separation
- (2018) Archa H. Fox et al. TRENDS IN BIOCHEMICAL SCIENCES
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- Nucleolar Function in Lifespan Regulation
- (2018) Varnesh Tiku et al. TRENDS IN CELL BIOLOGY
- Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery
- (2018) Sonja Kroschwald et al. Cell Reports
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
- (2018) Qingsong Gao et al. Cell Reports
- Treating p53 Mutant Aggregation-Associated Cancer
- (2018) Mathumai Kanapathipillai Cancers
- Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments
- (2018) Jill J. Bouchard et al. MOLECULAR CELL
- α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies
- (2018) Nadra Al-Husini et al. MOLECULAR CELL
- RNA polymerase II clustering through carboxy-terminal domain phase separation
- (2018) Marc Boehning et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phase Transitions Drive the Formation of Vesicular Stomatitis Virus Replication Compartments
- (2018) Bianca S. Heinrich et al. mBio
- RAS variant signalling
- (2018) Stephanie P. Mo et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
- (2018) Ann Boija et al. CELL
- Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs
- (2017) Yuan Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation
- (2017) Frederik De Smet et al. JOURNAL OF PATHOLOGY
- Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
- (2017) Jinfang Zhang et al. NATURE
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- (2017) Adam G. Larson et al. NATURE
- Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles
- (2017) Ming-Tzo Wei et al. Nature Chemistry
- Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors
- (2017) Hana Janouskova et al. NATURE MEDICINE
- Biomolecular condensates: organizers of cellular biochemistry
- (2017) Salman F. Banani et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nuclear speckles: molecular organization, biological function and role in disease
- (2017) Lukasz Galganski et al. NUCLEIC ACIDS RESEARCH
- SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
- (2017) C Geng et al. ONCOGENE
- Stress granule-associated protein G3BP2 regulates breast tumor initiation
- (2017) Nisha Gupta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride
- (2017) Mathumai Kanapathipillai et al. PROTEIN AND PEPTIDE LETTERS
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
- (2017) Susmitha Ambadipudi et al. Nature Communications
- Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies
- (2017) Lisa L. Hall et al. Cell Reports
- Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target
- (2017) Pramod Kumar Maurya et al. Journal of Cancer
- Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
- (2016) Zachary M. March et al. BRAIN RESEARCH
- A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas
- (2016) Alice Soragni et al. CANCER CELL
- Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
- (2016) Elda Grabocka et al. CELL
- The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules
- (2016) Hao Wu et al. CELL
- Compositional Control of Phase-Separated Cellular Bodies
- (2016) Salman F. Banani et al. CELL
- Coexisting Liquid Phases Underlie Nucleolar Subcompartments
- (2016) Marina Feric et al. CELL
- Phase separation in biology; functional organization of a higher order
- (2016) Diana M. Mitrea et al. Cell Communication and Signaling
- Liquid–liquid phase separation in cellular signaling systems
- (2016) P Andrew Chong et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles
- (2016) Melissa R Marzahn et al. EMBO JOURNAL
- Mechanistic insights into mammalian stress granule dynamics
- (2016) Marc D. Panas et al. JOURNAL OF CELL BIOLOGY
- G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits
- (2016) Nancy Kedersha et al. JOURNAL OF CELL BIOLOGY
- RAS isoforms and mutations in cancer at a glance
- (2016) G. Aaron Hobbs et al. JOURNAL OF CELL SCIENCE
- Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
- (2016) Chi W. Pak et al. MOLECULAR CELL
- Mutant p53 rescued by aggregation inhibitor
- (2016) Alexandra Flemming NATURE REVIEWS DRUG DISCOVERY
- Cajal bodies and snRNPs - friends with benefits
- (2016) David Staněk RNA Biology
- Role of FET proteins in neurodegenerative disorders
- (2016) Francesca Svetoni et al. RNA Biology
- Phase separation of signaling molecules promotes T cell receptor signal transduction
- (2016) Xiaolei Su et al. SCIENCE
- Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
- (2016) H. Broder Schmidt et al. TRENDS IN BIOCHEMICAL SCIENCES
- Principles and Properties of Stress Granules
- (2016) David S.W. Protter et al. TRENDS IN CELL BIOLOGY
- Transmissible Tumors: Breaking the Cancer Paradigm
- (2016) Elaine A. Ostrander et al. TRENDS IN GENETICS
- PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL
- (2016) A di Masi et al. Cell Death & Disease
- Virus assembly factories in a lipid world
- (2016) Isabel Fernández de Castro et al. Current Opinion in Virology
- The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity
- (2015) Gal Herzog et al. BIOCHEMISTRY
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Relating sequence encoded information to form and function of intrinsically disordered proteins
- (2015) Rahul K Das et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Peptide therapeutics: current status and future directions
- (2015) Keld Fosgerau et al. DRUG DISCOVERY TODAY
- YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1
- (2015) Syam Prakash Somasekharan et al. JOURNAL OF CELL BIOLOGY
- DDX3, a potential target for cancer treatment
- (2015) Guus Martinus Bol et al. Molecular Cancer
- Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation
- (2015) Jian An et al. MOLECULAR CELL
- SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
- (2015) Wenjian Gan et al. MOLECULAR CELL
- Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
- (2015) Yuan Lin et al. MOLECULAR CELL
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles
- (2015) William M. Aumiller et al. Nature Chemistry
- Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
- (2015) Lu Jiang et al. NATURE GENETICS
- Polymer physics of intracellular phase transitions
- (2015) Clifford P. Brangwynne et al. Nature Physics
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
- (2015) Tetsuro Murakami et al. NEURON
- The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
- (2015) Shana Elbaum-Garfinkle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation
- (2015) Evrim Gurpinar et al. TRENDS IN CELL BIOLOGY
- Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?
- (2015) Anaïs Aulas et al. Frontiers in Cellular Neuroscience
- Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system
- (2015) Sun-Hye Lee et al. Oncotarget
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
- (2014) Guoqiang Li et al. CANCER CELL
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- (2014) Patricia A.J. Muller et al. CANCER CELL
- Dragging Ras Back in the Ring
- (2014) Andrew G. Stephen et al. CANCER CELL
- Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
- (2014) C. Geng et al. CANCER RESEARCH
- Speckle-type POZ protein, SPOP, is involved in the DNA damage response
- (2014) D. Zhang et al. CARCINOGENESIS
- Mutational signatures: the patterns of somatic mutations hidden in cancer genomes
- (2014) Ludmil B Alexandrov et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Mutant p53 reactivation by small molecules makes its way to the clinic
- (2014) Vladimir J.N. Bykov et al. FEBS LETTERS
- TP53 Mutants in the Tower of Babel of Cancer Progression
- (2014) Alessandra Bisio et al. HUMAN MUTATION
- Clinical significance of different types ofp53gene alteration in surgically treated prostate cancer
- (2014) Martina Kluth et al. INTERNATIONAL JOURNAL OF CANCER
- Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli
- (2014) Katsutoshi Imamura et al. MOLECULAR CELL
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- p53 protein aggregation promotes platinum resistance in ovarian cancer
- (2014) Y Yang-Hartwich et al. ONCOGENE
- The aggregation of mutant p53 produces prion-like properties in cancer
- (2014) Luciana P Rangel et al. Prion
- mRNP granules
- (2014) J Ross Buchan RNA Biology
- Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
- (2014) J.-P. P. Theurillat et al. SCIENCE
- Prion-like aggregation of mutant p53 in cancer
- (2014) Jerson L. Silva et al. TRENDS IN BIOCHEMICAL SCIENCES
- PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation
- (2014) Umut Sahin et al. Nucleus
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains
- (2013) Ilmin Kwon et al. CELL
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- (2013) Warren A. Whyte et al. CELL
- Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders
- (2013) Mani Ramaswami et al. CELL
- Describing intrinsically disordered proteins at atomic resolution by NMR
- (2013) Malene Ringkjøbing Jensen et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport
- (2013) Hicham Mahboubi et al. PLoS One
- p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53
- (2013) Karolyn J. Forget et al. PLoS One
- Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
- (2013) C. Geng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
- (2013) R. K. Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Paraspeckle formation during the biogenesis of long non-coding RNAs
- (2013) Takao Naganuma et al. RNA Biology
- Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53
- (2013) Christopher D. Wassman et al. Nature Communications
- Post-translational modifications of PML: consequences and implications
- (2013) Xiwen Cheng et al. Frontiers in Oncology
- Differential Roles of PML Isoforms
- (2013) Sébastien Nisole et al. Frontiers in Oncology
- Mutational and expressional analyses ofSPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers
- (2012) Min S. Kim et al. APMIS
- Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
- (2012) Cristian A. Lasagna-Reeves et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
- (2012) Oliver D. King et al. BRAIN RESEARCH
- Transmissible Proteins: Expanding the Prion Heresy
- (2012) Claudio Soto CELL
- Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
- (2012) Masato Kato et al. CELL
- Virus factories: biogenesis and structural design
- (2012) Isabel Fernández de Castro et al. CELLULAR MICROBIOLOGY
- Advances in the Prediction of Protein-Peptide Binding Affinities: Implications for Peptide-Based Drug Discovery
- (2012) Joseph Audie et al. Chemical Biology & Drug Design
- Mutant p53: one name, many proteins
- (2012) W. A. Freed-Pastor et al. GENES & DEVELOPMENT
- Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
- (2012) Julien Couthouis et al. HUMAN MOLECULAR GENETICS
- A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
- (2012) Ellen Van Damme et al. International Journal of Biological Sciences
- Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils
- (2012) Ana P. D. Ano Bom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
- (2012) Sören Lehmann et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase transitions in the assembly of multivalent signalling proteins
- (2012) Pilong Li et al. NATURE
- Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
- (2012) Trevor J. Pugh et al. NATURE
- p53 mutations in cancer
- (2012) Patricia A. J. Muller et al. NATURE CELL BIOLOGY
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- (2012) Matthieu Le Gallo et al. NATURE GENETICS
- Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
- (2012) Christopher E Barbieri et al. NATURE GENETICS
- Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
- (2012) NATURE GENETICS
- Two Hundred Years of Cancer Research
- (2012) Vincent T. DeVita et al. NEW ENGLAND JOURNAL OF MEDICINE
- Specific Recognition of p53 Tetramers by Peptides Derived from p53 Interacting Proteins
- (2012) Ronen Gabizon et al. PLoS One
- Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles
- (2012) R. Miyagawa et al. RNA
- P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
- (2012) C. J. Decker et al. Cold Spring Harbor Perspectives in Biology
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3–SPOP E3 ubiquitin ligase complex
- (2011) Bogyou Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis
- (2011) Kenzui Taniue et al. EMBO REPORTS
- Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
- (2011) Jie Xu et al. Nature Chemical Biology
- SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
- (2011) Lili Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes
- (2011) C. P. Brangwynne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
- (2011) N. Stransky et al. SCIENCE
- Biogenesis and function of nuclear bodies
- (2011) Yuntao S. Mao et al. TRENDS IN GENETICS
- Identification of importin α1 as a novel constituent of RNA stress granules
- (2010) Ken Fujimura et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Sequence Determinants of Compaction in Intrinsically Disordered Proteins
- (2010) Joseph A. Marsh et al. BIOPHYSICAL JOURNAL
- MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes
- (2010) Keiko Tano et al. FEBS LETTERS
- Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors
- (2010) Claudia B. Levy et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Prion-like disorders: blurring the divide between transmissibility and infectivity
- (2010) M. Cushman et al. JOURNAL OF CELL SCIENCE
- The mechanism of eukaryotic translation initiation and principles of its regulation
- (2010) Richard J. Jackson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Prion-like transmission of protein aggregates in neurodegenerative diseases
- (2010) Patrik Brundin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- Net charge per residue modulates conformational ensembles of intrinsically disordered proteins
- (2010) A. H. Mao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Charge interactions can dominate the dimensions of intrinsically disordered proteins
- (2010) S. Muller-Spath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Cajal Body and Histone Locus Body
- (2010) Z. Nizami et al. Cold Spring Harbor Perspectives in Biology
- Nuclear Speckles
- (2010) D. L. Spector et al. Cold Spring Harbor Perspectives in Biology
- PML Nuclear Bodies
- (2010) V. Lallemand-Breitenbach et al. Cold Spring Harbor Perspectives in Biology
- Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation
- (2009) Daniella Ishimaru et al. BIOCHEMISTRY
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins
- (2009) Simon Alberti et al. CELL
- Modes of p53 Regulation
- (2009) Jan-Philipp Kruse et al. CELL
- The p53 Core Domain Is a Molten Globule at Low pH
- (2009) Ana Paula D. Ano Bom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
- (2009) Min Zhuang et al. MOLECULAR CELL
- A small-cell lung cancer genome with complex signatures of tobacco exposure
- (2009) Erin D. Pleasance et al. NATURE
- A comprehensive catalogue of somatic mutations from a human cancer genome
- (2009) Erin D. Pleasance et al. NATURE
- The cancer genome
- (2009) Michael R. Stratton et al. NATURE
- RNA granules: post-transcriptional and epigenetic modulators of gene expression
- (2009) Paul Anderson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay
- (2009) Wei-Lun Chang et al. NUCLEIC ACIDS RESEARCH
- p53, secreted by K-Ras–Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker
- (2009) S-H Lee et al. ONCOGENE
- Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
- (2009) Qing Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
- (2009) C. P. Brangwynne et al. SCIENCE
- The TET Family of Proteins: Functions and Roles in Disease
- (2009) A. Y. Tan et al. Journal of Molecular Cell Biology
- Mutant p53 Gain-of-Function in Cancer
- (2009) M. Oren et al. Cold Spring Harbor Perspectives in Biology
- The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies
- (2008) Stefania Rigacci et al. BIOPHYSICAL JOURNAL
- A History of Cancer Chemotherapy
- (2008) Vincent T. DeVita et al. CANCER RESEARCH
- Recent advances in the molecular pathology of soft tissue sarcoma: Implications for diagnosis, patient prognosis, and molecular target therapy in the future
- (2008) Yoshinao Oda et al. CANCER SCIENCE
- The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2–DAXX–HAUSP complex
- (2008) Min Sup Song et al. EMBO JOURNAL
- PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation
- (2008) Y. Shima et al. MOLECULAR AND CELLULAR BIOLOGY
- DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
- (2008) Timothy J. Ley et al. NATURE
- Ras oncogenes: split personalities
- (2008) Antoine E. Karnoub et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Small stress molecules inhibit aggregation and neurotoxicity of prion peptide 106–126
- (2007) Mathumai Kanapathipillai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search